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Biomedical subjects

P Bailer

Publications and source records attributed to P Bailer.

At least 19 recordsLinked to original sources
PubMed1980

[The serum levels of estradiol-17 beta and progesterone following hyper-stimulation of the ovaries by clomiphen].

The serum levels of estradiol-17 beta and progesterone in a cycle which was hyperstimulated by Clomiphen are reported. The pre-ovulatory maximum of estradiol-17-beta was 3,240 pg/ml, the maximum during the luteal phase was 2,930 pg/ml. The increase of progesterone to 54.8 ng/ml during the luteal phase was an indication of multiple ovulation. Bilateral ovarian enlargement was palpated. At the same dosage in the following menstrual cycle the maximum pre-ovulatory estradiol-17-beta was 962 pg/ml and the maximum progesterone in the luteal phase was 9.1 ng/ml. During this second cycle the ovaries were not palpably enlarged. It is concluded that sensitivity of the ovaries to hyper-stimulation by Clomiphen may vary from menstrual cycle to menstrual cycle. A single hyperstimulation does not necessarily indicate further hyperstimulation in subsequent cycles.

Adult↗
PubMed1980

alpha-Fetoprotein, carcinoembryonic antigen, human chorionic gonadotropin and its beta subunit in metastatic choriocarcinoma: short-term follow-up and determinations of resistance during chemotherapy.

Serum levels of alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), human chorionic gonadotropin (hCG) and its beta subunit (beta-hCG) were measured during the therapy of a choriocarcinoma with lung metastases. All AFP determinations were in the normal range. The CEA levels showed a correlation with the radiologically confirmed development of lung metastases. A rise of hCG during the first 2--6 days to 177.3--407.5% of the initial level and a descent to 17.9--33.7% of the initial level at the 10th day of therapy were typical behavioral patterns associated with tumor sensitivity. The onset of tumor resistance against the chemotherapeutic preparation used was evident within 10 days after therapy. A small rise, a slight fall below the initial value, and then a rapid increase to above the initial level were typical parameters. With established tumor resistance there was an autonomous unremitting increase of hCG activity. Short-term follow-up to hCG in intervals of 2 days at least for over a period of 10 days are deemed advisable for early detection of resistance toward the particular chemotherapeutic preparation used.

Adult↗
PubMed1980

[Audio-visual information on the post-partum ward (author's transl)].

About 70% of the maternity patients obtain their information from magazines. About 75% of the patients stated that they had sufficient knowledge of breast feeding and care for the newborn. But only 56% had sufficient information on the nutrition of infants. The preferred films had contents on the correct behaviour in pregnancy, on the recognition of hereditary disease and congenital anomalies during pregnancy and on the normal delivery. The maternity patients wanted to be informed by the physician on the above subjects. Cassette television has proven to be valuable but it not as much requested as other methods of information.

Audiovisual Aids↗
PubMed1979

[Problems of dextran-charcoal-separation of free from antibody-bound steroid in a direct radioimmunoassay of progesterone without chromatography and extraction (author's transl)].

A method for radioimmunoassay of serum progesterone is described which does not require extraction. A chromatographic step is not necessary because of the high specifity of the antibody. The intrassay coefficient of variation was 6.1% and the interassay coefficient of variation was 8.4%. The detection limit was 10 pg/tube that means 1 ng/ml serum. The test on parallelity was correct up to 10 microliter serum. The results compared with results of a radioimmunoassay with extraction were identical. High concentrations of hormone in serum and an antibody of high specifity are required for the direct radioimmunoassay of steroids. Using the dextran-charcoal system for separation of free from antibody-bound steroid the relationship of the quantity of serum to the quantity of charcoal is of great importance. These problems are discussed.

Charcoal↗
PubMed1979

[Serumprolactin and lactation in a case of placental sulfatase deficiency].

In a pregnancy with placental sulfatase deficiency very low serum concentrations of estrone and estradiol-1 7 beta are found. Estriol is not detectable. In spite of this serum concentrations of prolactin were in the normal pregnancy range. There was no premature lactation in pregnancy. Lactation in puerperium was unsatisfactory.

Estradiol↗
PubMed1978

[Diagnosis of placental sulphatase deficiency (author's transl)].

In a 23-year old primipara who was in her 34th week of pregnancy, serum oestriol could not be identified, with no other abnormal clinical and endocrinological findings, which is why the authors suspected placental sulphatase deficiency. The placental sulphatase activity was tested by the intravenous application of dehydroepiandrosterone sulphate, and compared with the data obtained from a control patient with normal endocrinological findings. There was a slight increase in DHEA from 7.5 ng/ml to 18.0 ng/ml, whereas the serum values of oestrone and oestradiol did not change. In contrast, the control patient showed an excessive increase of DHEA from 5.5 ng/ml to 56.8 ng/ml. Oestrone and oestradiol also reacted with a strong increase of activity from 12.7 ng/ml to 42.7 ng/ml or 25.2 ng/ml to 61.2 ng/ml, respectively. A placental sulphatase deficiency with absence of hydrolysis of the applied DHEAS must be assumed as the reason for the deficient or absent reaction of DHEA and the oestrogens. The patient gave birth to a healthy boy in the 41st week of pregnancy, delivery being performed by caesarian section. Clinically normal course of pregnancy with lowered oestriol values, delivery by caesarian section in the case of primiparae, as well as male sex of the newborn, are criteria of placental sulphatase deficiency. These criteria correspond to the few observations published so far.

Adult↗
PubMed1977

[Experience with the trans-uterine tubal coagulation with high frequency current and the thermo method under hysteroscopic control (author's transl)].

With the aid of the carbon dioxide hysteroscope, 152 patients underwent transuterine tubal sterilization. 106 women had high frequency current coagulations of the tubes. At follow-up examinations 62 tubes were occluded and 30 showed a unilateral tubal occlusion. These results did not improve by using the thermo coagulation method since only 10 out of 24 patients showed bilateral tubal occlusion and two unilateral tubal occlusions. Up to 20 months following the transuterine tubal sterilization, 28 of the 152 women became pregnant. Of these, 16 became pregnant in spite of hysterosalpingographic evidence of bilateral tubal occlusion. Two patients required emegency laparotomies because of small bowel injuries. Within the coagulation times and temperature ranges used in this series, the results of trans-uterine tubal sterilization are unsatisfactory. It is possible that other types of hysteroscopic tubal sterilizations which are now being developed will be more successful.

Adult↗
PubMed1976

[The psychological results of tubal ligation as definitive method of contraception (author's transl)].

The cases of tubal ligation at the University Department of Tubingen and the University Department of Giessen during the last few years were reviewed. In most cases the psychological results of the procedure is positive and results in an improved partner relationship in most cases, provided that the procedure was the result of a mature decision by the couple. Tubal ligation in the puerperium is more favorable than in conjunction with the Caesarean Section. Interval sterilization shows the best results. A thorough discussion by the physician and if possible a psychological discussion should take place prior to the tubal ligation since both are important aids in the decision. The social indication should be clearly defined and the responsibility of the couple should be emphasized. A well defined and documented task for the clinical practice of prior physician and psychological discussion of tubal ligation is the basis of a present prospective study at the University Department for Women in Tubingen which is designed to show the positive psychological effects on the couple.

Adult↗
PubMed1975

[Gynaecological laparoscopy (author's transl)].

The double puncture laparoscopy was abandoned in our department in favor of the single puncture technique. 187 diagnostic laparoscopies and 617 laparoscopic tubal ligations are reviewed. In 46% of the diagnostic laparoscopies, the findings were confirmed. In 40% of the diagnostic laparoscopies, normal findings were seen and in 11%, a different abnormal finding than suspected was found. In 3% of women, the findings could not be elucidated by laparoscopy. None of the 617 patients who underwent laparoscopic tubal sterilization have become pregnant. In 5% of the patients (0.6%) complications occurred. In 3 cases a laparotomy became necessary. In 2 cases there was bleeding from the fallopian tube or the greater omentum and in 1 case there was a trauma to the intestine. Laparoscopic tubal sterilization by the single puncture technique and coagulation without division of the tube only, is considered to be the lowest risk method of the laparoscopic tubal sterilizations.

Abdominal Injuries↗