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Biomedical subjects

P Barrellier

Publications and source records attributed to P Barrellier.

At least 19 recordsLinked to original sources
PubMed1995

[Extemporaneous histologic examination of cutaneous carcinoma of the face].

One hundred thirty-eight skin cancers of the face were reviewed retrospectively in order to evaluate the extemporaneous histology examination. The results obtained were satisfactory and in agreement with those in the literature. This technique is perfectly adapted to cancers with a facial localization. In our opinion, the indication for extemporaneous examinations should be widened to all cases of epithelioma of the face.

Aged↗
PubMed1992

[The use of cryotherapy in oral pathology. Our experience in 36 cases].

Cryotherapy is a simple to use, weakly invasive technique provoking only moderate complications in the treatment of certain mucosal lesions of the buccal cavity. Indications of choice for this type of treatment are angioma and papilloma. Long term follow up of patients treated for reactive keratosis or epithelioma in situ is at present insufficient to establish precise indications.

Carcinoma in Situ↗
PubMed1991

[Epidermoid carcinoma of the lip. The contribution of surgery. Apropos of 429 cases].

The surgical treatment of epidermoid carcinoma of the lip too rarely resorts to pluri-disciplinary confrontation, although all the possible techniques, i.e. surgery, curietherapy and radiation therapy, are effective. Curietherapy still is the choice method for large lesions, due to the quality of its aesthetic and functional results. The lymph node areas of N0 patients are neglected but should not be so, because the secondary evolution of an adenopathy has a poor prognosis. All the T2 and T3 patients with no general contraindication should undergo cervical exploration.

Adult↗
PubMed1991

[Basocellular epitheliomas of the eyelids].

On the basis of a retrospective study of 354 basal-cell epitheliomas of the eyelids, we present a study of the most frequently used treatments: surgery, conventional radiation therapy and curietherapy. The results of treatment, both functional and oncological, are generally satisfactory, whatever the method chosen, but with a set of arguments in favor of surgery. The major therapeutic indications are discussed, without formally ruling out any treatment.

Adolescent↗
PubMed1991

[Medical treatment of osteoradionecrosis].

The medical treatment of radiation-induced osteitis is advocated by all, with highly variable practical modalities. In our historical series, we have noted 12 good results out of 48 patients treated. In the light of R. Dambrain's work, we have used a procedure associating two antibiotics to Calcitonin during more than two months, with encouraging results.

Amoxicillin↗
PubMed1991

[The value of extemporaneous study of the surgical margins of cancers of the upper aero-digestive tract. Apropos of 129 cases of oral and oropharyngeal tumors].

129 patients, who had oral cavity or oropharyngeal carcinoma underwent excision with intraoperative histopathologic examination. Thanks to this method, the number of satisfying resections has increased from 25% to 75%. Whatever the quality of the surgical excision may be, postoperative radiotherapy improves the prognosis.

Carcinoma in Situ↗
PubMed1987

Analysis of the results of the micronucleus test in patients presenting upper digestive tract cancers and in non-cancerous subjects.

A micronucleus test was performed on 75 subjects of whom 38 presented with cancer of the upper digestive tract and 37 were free of disease; the absence of cancerous or pre-cancerous lesions in this latter group was confirmed by endoscopy and vital staining. The daily levels of alcohol and tobacco consumption of the 75 subjects were determined by precise questioning: 78% of the non-cancerous subjects smoked less than 10 g of tobacco per day whereas 79% of the cancer patients smoked 10 g or more daily. The alcohol intake of 78% of the non-cancerous subjects and 63% of the cancer patients was less than 101 ml per day. Only 10% of the cancer patients had combined daily intake levels corresponding to the threshold of sensitivity of the micronucleus test as defined by previous studies. The mean frequency of micronucleated buccal cells was 0.26% in the cancer patients and 0.13% in the non-cancerous subjects. All non-cancerous patients presented a negative test. Only 5% of the cancer patients presented a micronucleated cell frequency above 1% and could thus be considered as positive. It thus appears that the micronucleus test was not significantly positive in our population of 38 cancer patients.

Adult↗
PubMed1985

[Screening for cancer of the upper aerodigestive tract in a high-risk population].

From the data collected in the Cancer Registry of Calvados, a screening program for neoplastic lesions of the whole upper digestive and respiratory tract was performed in a canton where esophageal cancer incidence is very high. 137 men underwent this examination for mouth, pharyngo-larynx and esophagus. None neoplastic lesion was revealed but histologic and cytologic swabs showed some abnormalities that are now being studied.

Adult↗
PubMed1985

[Lymphatic invasion of cancers of the oral cavity. A diagnostic strategy].

The diagnostic of ganglionnary invasion in oral cancer is established throughout the histological investigation practiced during the operation. This histological inquiry has to be rigorous and logical, in conformity with the anatomical particularities of the drainage tubes of the oral mucous. The accurate execution of this diagnostical strategy applied to the ganglionnary invasion improves the prognostic but requires a good logistic support.

Humans↗
PubMed1985

[Cancer registry of Calvados, hospital registry of the François- Baclesse Center and mortality statistics: comparisons].

Incidence rates of the cancer registry of the department of Calvados were compared, by site and by age group, with those obtained from the cancer registry of the comprehensive cancer center in Caen, concerning the population of the department of Calvados. In males, these rates are approximately similar for head and neck sites; for the hospital registry they are 50% of those recorded by the population registry for lung cancer, and 30% for prostatic cancer. In females, the all-sites rates are nearly identical for the youngest age groups and 50% for the older. They are not significantly different for digestive cancer, and 75% for cervix and breast cancer. The incidence rates of both registries were compared with mortality rates. They indicate mortality rates which appear relatively high for the pancreas, and they show imprecisions for the uterus and head and neck (pharynx-larynx) sites.

Adult↗
PubMed1980

[Detection of buccal cavity cancers with toluidine blue (author's transl)].

When malignant tumours of the oral cavity are of a small size, they are asymptomatic during a long time, and it is difficult to detect them. A method permitting to discover them more easily during the examination would be a precious rescue. In this aim, we have tested the oral coloration with toluidine-blue in 50 patients with a high risk of malignant tumour. This coloration has allowed to reveal cancer in 3 patients whereas no tumour was found at previous clinical examination.

Humans↗
PubMed1979

[Micrographic aspect of mandibular osteoradionecrosis (author's transl)].

Fragments of the lower jaw from 42 patients with carcinoma of the oral cavity or oropharynx, and treated primarely with fraction radiotherapy, were excised for radiation osteonecrosis 6 month to 10 years after irradiations. The excised specimens are X-rayed before being coated with methylmetacrylate. They are then cut into thick sections along lines detailled on the X-ray films. The sections are trimmed to 80 microns and examined microradiographically. Two observations are sufficient to demonstrate destruction or reorganisation of the bone tissue. Reabsorption of unusual appearance is seen around the Haversian canals. The newly formed tissue resembles either embryonic bone matter, or lamellar tissue as seen in osteomyelitis.

Aged↗