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Biomedical subjects

P Bastide

Publications and source records attributed to P Bastide.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Synthesis and pharmacologic study of several spirohydantoins: relation to conformation].

Using two routes starting from cyclanones, it has been possible to prepare two series of spirohydantoins substituted or not on the hydantoin nucleus nitrogen. These compounds exhibited low toxicity on pig lens aldose reductase (except for two compounds). A discussion is given on the steric and geometric requirements for effective enzyme inhibiting activity.

Aldehyde Reductase↗
PubMed1988

Pharmacokinetic patterns of repeated administration of antidepressants in animals. I. Implications for antinociceptive action of clomipramine in mice.

The pattern of repeated administration of antidepressants in animals varies from one study to another, making comparison of results difficult. We propose a means of standardizing the pattern of administration for any particular animal, based on a pharmacokinetic study of the antidepressant [here clomipramine (CMI)] in that animal. The plasma half-life (127 min) in the Swiss CD1 mouse was used as a basis for chronic administration, which was strictly every half-life as in clinical use. Daily administration is thus merely repeated acute administration. The antinociceptive action of CMI was compared under four sets of conditions of injection: single, chronic, daily and closely repeated (every 40 min). The antinociceptive effect obtained after an acute injection of CMI (10 or 20 mg/kg i.p.) was increased 2-fold after five chronic injections. Closely repeated injections gave a more marked effect than chronic administration, and daily administration was ineffective. The time course of the antinociceptive action correlated with that of blood and brain levels of CMI and its monodemethylated derivative. The enhancement of the antinociceptive action observed after chronic and closely repeated administration was shown not to be due to any modification of motor activity. It was suppressed by naloxone. Comparison with results reported in the literature shows the benefit of using a well-defined pattern of administration.

Analgesics↗
PubMed1987

[Synthesis and pharmacologic evaluation of some dihydropyran carboxylic acids].

The synthesis of three new dihydropyran carboxylic acids has been performed by uncommon procedures: cyanosilylation, cyclisation of oxime. Their chemical structure was confirmed by I.R. and N.M.R. data. In a pharmacological evaluation they were found to possess significant effects on the passive cutaneous anaphylaxis test and on the central nervous system; one of them showed an interesting antiallergic effect whilst another showed an interesting sedative effect.

Analgesics↗
PubMed1977

[Action of pharmacological effectors on hematocrit and lactate dehydrogenase activity changes in experimental ischemic shock].

The experimental ischemic shock induced by removing tourniquets in rats, were studied. Durin 164 hours, the variations of the values of hematocrit and of muscle and plasma dehydrogenase lactate activity were followed up; the modifications of these variations after pharmacological high doses of dexamethasone phosphate, hydrocortisone hemisuccinate and aprotinine administered intravenously, were evaluated. The best action was noted after dexamethasone phosphate treatment.

Animals↗
PubMed1976

[Variations of various enzymatic activities of the Krebs cycle (malate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase) during experimental ischemic shock in the rat. Influence of adenosine 5' triphosphoric acid].

During the ischemic shock caused by the removal of tourniquets placed on the hind paws of the rat, a marked decrease in the enzyme activities of Krebs cycle yielding ATP (malate dehydrogenase, isocitrate dehydrogenase, succinate dehydrogenase) at the level of the gastrocnemius muscle and the liver, was observed together with a plasma increase of these enzymes. The intraperitoneal injection of ATP diminishes significantly the variations observed.

Adenosine Triphosphate↗