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Biomedical subjects

P Beauregard

Publications and source records attributed to P Beauregard.

10 recordsLinked to original sources
PubMed2000

[Chronic lymphoid leukemia complicated with ascites].

Ascites are common in malignancies of the gastrointestinal tract but are rarely associated with chronic lymphoid leukemia. An unusual progression of chronic lymphoid leukemia, rapidly complicated with ascites, is presented, followed by a discussion of the causes and types of ascites found in solid and blood malignancies.

Ascites↗
PubMed1995

Monoclonal antibodies in the management of acute leukemia.

This report reviews the diagnostic significance of immune markers, their relationship to patient outcome, and the therapeutic uses of monoclonal antibodies (MoAbs) in acute leukemia. Immunophenotyping allows for rapid and reproducible diagnosis in the majority of cases of acute leukemia. It is of particular importance in recognizing the major immunologic subclasses of acute lymphoblastic leukemia (ALL), and in identifying subtypes of acute myeloblastic leukemia (AML) which cannot be differentiated by morphology and cytochemistry alone, such as FAB M0 or M7. Immune marker analysis has been used to detect minimal residual disease in patients' bone marrow and CSF after treatment. However, the presence of leukemia-associated phenotypes on small numbers of normal cells may reduce the sensitivity of detection in some cases. The prognostic value of immune markers in AML is limited. In ALL, the prognostic significance of the different immunophenotypic subtypes has been lessened by modern treatment protocols. The relationship of mixed-lineage or biphenotypic antigen expression to patient outcome in both AML and ALL is unclear. Therapeutic applications of MoAbs in acute leukemia include immunologic techniques for purging malignant cells from autografts prior to transplantation, T-lymphocyte depletion from allografts as a strategy to reduce graft-versus-host disease, and the use of flow cytometry to monitor the timing and extent of leukapheresis in peripheral stem cell transplantation. MoAbs have also enabled the recent development of transplantation protocols using positively-selected CD34+ stem cells.

Acute Disease↗
PubMed1991

Models of S-phase determination in lymphomas from flow cytometric DNA content histograms: comparison with the bromodeoxyuridine labeling index.

The estimated S-phase fraction (%S) of non-Hodgkin's lymphomas has been demonstrated to be of prognostic value. The %S can be determined by labeling index (LI) techniques or by various mathematical models applied to DNA content histograms. We performed DNA content analysis and a slide-based bromodeoxyuridine immunofluorescence LI on split samples from 117 biopsy specimens suspicious for lymphoma. The LI was compared with the %S determined by two computer models (rectangular and polynomial) with and without debris subtraction, and a manual gates computer model. In the 93 DNA diploid cases, the rectangular models had the highest correlation with the LI (R = 0.88). In the 24 aneuploid cases, the manual gates model was the most useful because of a high correlation with the LI (R = 0.70) and its ability to be used in most cases (23/24). The polynomial models had limited usefulness because they generally gave a higher %S than the LI and could be fitted in less than half of the DNA aneuploid histograms. These results suggest that in situations where the LI is not possible, an accurate %S estimate can usually be obtained with either a rectangular or manual gates model.

Bromodeoxyuridine↗
PubMed1988

A surface durable and strongly bonded phosphor viewing screen for T.E.M.

A simple procedure is described for the preparation of a totally inorganic, durable, strongly bonded, and non-shrinking phosphor viewing screen. The procedure requires no special apparatus or skills in order to prepare a fairly uniform high resolution screen in only about 0.5 hours plus drying time. The screens are suitable for use on an automatic exposure system where mechanical shock can destroy a screen.

Microscopy, Electron↗