Biomedical subjects

P Benders

Publications and source records attributed to P Benders.

4 recordsLinked to original sources

PubMed1980

[57Co-bleomycin kinetics after local and systemic administration].

Using a mouse tumor model, an attempt was made to determine whether demonstrable differences could be established for the excretion and organ distribution of labeled bleomycin, whereby the tumor and local lymph node concentration were given special consideration. No significant differences could be established for the excretory behavior with different methods of application (i.t., i.v.). Organ distribution studies however showed that the blood and organ load after intravenous administration of 57Co bleomycin was higher and the tumor concentration significantly lower than after injection directly into the tumor. The lower organ load following injection directly into the tumor was investigated with a toxicity test.

Administration, Topical↗

PubMed1979

Kinetics of 57Co-bleomycin in mice after intravenous, subcutaneous and intratumoral injection.

In tumor-free and tumor-bearing mice the body clearance and organ distribution of 57Co-BLM was measured in different time intervals after iv, sc, and it administration of the drug. No significant differences could be demonstrated in body clearances following different doses and routes of application of labeled BLM in tumor-free and tumor-bearing mice. The organ distribution studies showed higher concentrations following iv compared to sc or it application of 57Co-BLM; however, the activity in the ipsilateral injection sites were significantly increased after sc and it injection. In tumor-bearing mice the activity in the draining lymph nodes of the injection site were as high as that seen in draining lymph nodes following iv injection. However, on the contralateral side, the lymph node concentration was significantly reduced after it injection. These results indicate on the basis of organ distribution of 57Co-BLM a rational basis for it treatment of malignant tumors.

Animals↗

PubMed1979

[Concentrations of cytostatic drugs in organs and tumors: comparison after intravenous and intratumoral injection (author's transl)].

The cytostatic drugs Chlorambucil and Bleomycin were labeled with 131I and with 57Co, respectively: Ruthenocenealdehyde-(N-methyl-N-beta-chlorethyl)-hydrazone and Ruthenocene-3-phenyl-prop.1-en-3-one were labeled with the gamma emitter 103Ru. In tumor-bearing mice the elimination and organ distribution of these radioactive substances were tested after intravenous (i.v.) and intratumoral (i.t.) injection of the drugs. The organ load showed lower values after i.t. than after i.v. application, while the radioactivity concentrations in the tumor were considerably increased after i.t. injection. The integrals of the concentration-time curves showed 10--80 times higher concentrations in the tumor after i.t. compared to i.v. injection of the drugs.

Animals↗

PubMed1979

57Co-bleomycin kinetics in normal and tumour-bearing mice after systemic and local administration.

In tumour-free and tumour-bearing mice the body clearance and organ distribution of 57Co-BLM was measured at different time intervals after iv., sc., and it. administration of the drug. No significant difference could be demonstrated in body clearance following different doses and routes of application of labelled BLM in tumour-free and tumour-bearing mice. The organ distribution studies showed higher concentrations following iv. compared to sc. or it. of 57Co-BLM; however, the activity in the ipsilateral injection sites was significantly increased after sc. and it. injection. In tumour-bearing mice the activity in the lymph nodes draining injection site was as high as that seen in the draining lymph nodes following iv. injection. However, on the contralateral side, the lymph node concentration was significantly reduced after it. injection. These results indicate on the basis or organ distribution of 57Co-BLM a rational basis for it. treatment of malignant tumours.

Animals↗