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Biomedical subjects

P Bertolani

Publications and source records attributed to P Bertolani.

At least 19 recordsLinked to original sources
PubMed2000

[Model of integrated hospital project for the management of patients at risk of sudden death syndrome].

Home cardiorespiratory monitoring (HM) is an accepted practice in infants at high risk for Sudden Infant Death Syndrome (SIDS) as those with the following conditions: 1) Siblings of SIDS; 2) Apparent Life Threatening Events (ALTE); 3) Apneas of prematurity. From 1998 the Division of Neanotology of the Policlinico of Modena has followed prospectively infants at high risk for SIDS, in collaboration with the General Health Service. To support the clinical trial 10 apnea monitors were provided by the General Health Service and managed from the Department of Neonatology. During 18 months 24 infants have been followed by HM, and among then 20 were at risk of SIDS (11 female and 9 male): 7 were siblings of SIDS (35%); 10 had previous episodes of ALTE (50%); 3 were born prematurely and had persistent apneas before discharge (15%). The mean period of HM was 5.85 months. None of the infants died for SIDS or had episodes of ALTE that required resuscitation measures. In only one case parents stopped earlier than recommended, but personal interview to parents showed that all the others families gained benefits and reassurance from HM.

Humans↗
PubMed1998

[High prevalence of hepatitis C virus infection in patients with non-Hodgkin's lymphoma at the onset. Preliminary results of an Italian multicenter study].

143 patients with non-Hodgkin lymphoma (NHL) at the onset entered this perspective study on NHL-associated risk factors. They were 87 males and 56 females with a mean age of 52.3 years (range 14.6-82.3). An associated hepatitis C virus (HCV) infection was found in 16 of the 143 NHL cases (11.2%; 95% CI 6.5-17.5). They were 11 males and 5 females [mean age 59.9] year with disseminated (13/16) or localized NHL disease (3/16)]. The NHL histological subgroup was low grade (6/16), intermediate grade (2/16) or high grade (8/16). The cell origin was B in 15/16 cases and B cell-T cell rich in 1/16. The discovery of HCV infection was contemporary to lymphoma diagnosis in 6/16 cases but preceded the NHL onset in the other 10 patients. In these 10 patients the median time between HCV infection diagnosis and NHL onset was 3.6 years (range 1-14.5). These data confirm that in Italy the prevalence of HCV infection in patients with NHL (11.2%) is significantly higher than expected in the general population (1.3-3.2%). The finding that, in most cases, HCV infection was definitely antecedent to NHL onset, usually by years, adds evidence to the possible causative role of the HCV in lymphomagenesis.

Adolescent↗
PubMed1995

[Experimentation and clinical analysis of the interrelationships between dental damage and celiac disease].

Celiac disease is characterized by gluten-dependent atrophy of the intestinal tufts. Aetiologically the genetic "habitus" of the subject has particular importance and, as rear as the pathogenesis is concerned, many theories, among which the most accredited one is "immunopathological", exist. According to what this last one provides, the cell-mediated immunity component is to be considered the true mediator of intestinal injury, whereas the antibody-mediated component and, in particular, anti-gliadin antibodies (AGA) and anti-endomysium antibodies (EMA), has a particular and pre-eminent diagnostic role. Just from this point of view the celiac disease appeared, with the progress of the studies, to be more and more fleeting, because of growing symptomatologic diversification. It is then interesting to take into account that the celiac disease seems to be able to maintain itself asymptomatic for the greatest part of life, perhaps, forever, configuring the appearance of silent celiac disease and contributing to specify the outline of the above-mentioned celiac "habitus". Recently, besides, close associations have been found between many different diseases and celiac disease. Even for such reasons we relied upon the indication of the ESPGAN in order to achieve a sure and standardized diagnosis of celiac disease. Early diagnosis of celiac disease is very important because it allows a normal psychophysical development and it avoids the strong incidence of lymphomas and other neoplasms of the gastrointestinal tractus which can characterize the natural story of celiac patients. From a more specifically odontological point of view, interesting manifestations exist in the ambit of celiac disease. This last may in fact appear associated particular signs, such as recurrent aphthae or plainly autoimmune diseases with even oral verification. There, however, a more frequent association between celiac disease and some lesions of the tooth enamel which occur in the period of the two stages of histodifferentiation and mineralisation, and they are, respectively, hypoplasias and opacities. Alteration of the enamel, in such stages, both in deciduous and in permanent sets of teeth may be caused by different "noxae"; hence it will be necessary to know how to distinguish between the dental lesions typical of celiac disease and the others. It is helpful the fact that the dental lesion, observed in the course of celiac disease, remembers conceptually the Chronologic Hypoplasia of the enamel. This pathologic form damages the enamel which is depositing, and evolving contemporaneously to the local or systemic "noxa" which is its remote cause.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1984

BT-Paba test in the diagnosis of pancreatic exocrine insufficiency in cystic fibrosis: urinary and serum determinations compared.

Urinary recovery and serum determination of Paba were carried out in 48 control children (C) and 53 paediatric patients with cystic fibrosis (CF) divided into three classes by age. Ninety and 120 min after the ingestion of 15 mg/kg of BT-Paba and of a standard meal, serum Paba was determined. In the same subjects the percentage Paba recovery was measured in the urine collected during an 8 h period after the same administration of BT-Paba. Correlation between urinary and serum Paba values was higher in the older children in respect to the 0-2-year-old infants. A urinary Paba test was less sensitive and specific than a serum Paba test in the evaluation of exocrine pancreatic function. The best discrimination between C and children with CF, using the maximal value of serum Paba at 90 or 120 min (peak), was obtained in the younger infants (0-2 years old). BT-Paba test with serum Paba peak determination is recommended as a substitute for the classical urinary Paba test in the evaluation of exocrine pancreatic function in paediatric patients, especially in the younger infants.

4-Aminobenzoic Acid↗
PubMedDate not supplied

[Celiac disease and lymphoma].

Celiac disease (CD) has been acknowledge as being responsible for numerous secondary pathologies, in particular autoimmune and neoplastic diseases. Whether CD is more prevalent in patients with non-Hodgkin's lymphoma (NHL) than in the normal population is not known. Accordingly, we carried out a study of 86 patients hospitalized in the Section of Oncology, Haematology and Internal Medicine of the Department of Medical, Oncological and Radiological Sciences of the University of Modena and Reggio Emilia and who, between 1988 and 1995 had been diagnosed as affected by NHL. On diagnosis, and before the beginning of antitumour therapy, all the patients were tested for antigliadin (AGA IgA and IgG) and antiendomysium (EMA) antibodies together with total class IgA antibody levels. Our findings showed that none of the 86 patients had an IgA deficit, while one tested positive for AGA IgA (43.9% v.n. < 7.5). The same patient also tested positive for EMA. The extremely high sensitivity and specificity of the AGA IgA and EMA led us to conclude that the patient was affected by CD, although his early death precluded confirmation by biopsy. The presence of one celiac patient among 86 NHL patients examined at the onset of the disease would suggest that CD is not infrequent in NHL. The numbers involved in our study are insufficient for statistical purposes, and we are therefore awaiting the results of a SIGEP multi-centre study into the connection between CD and lymphomas.

Adolescent↗
PubMedDate not supplied

[Coexistence of cystic fibrosis and celiac disease. Description of a clinical case and review of the literature].

A 14-month-old female infant with chronic diarrhea, recurrent respiratory infections and stunted growth was diagnosed as celiac disease with AGA detection and a positive intestinal biopsy. A gluten-free diet was introduced with a poor response. A sweat test was positive and heterozygosis for mutation of CFTR gene (both F508 and G542X) was found, demonstrating an association in the infant between cystic fibrosis and celiac disease. Fifteen cases of such association have been previously described in literature, but only three have been genetically studied. The co-existence of cystic fibrosis and celiac disease in the same subject has to be considered till now a casual finding, but are also discussed hypothesis of a non-casual linkage, formulated by some authors.

Celiac Disease↗
PubMedDate not supplied

[Unusual cause of ileal occlusion: a coconut bezoar].

A coconut phytobezoar was detected in the distal ileum of a 4-year-old boy, admitted for suspected appendicitis. While persimmon or citrus fruit ingestion has been previously reported as cause of phytobezoar intestinal occlusion, it is the first time that coconut pulp is described to cause ileal obstruction in children. No predisposing factor as previous gastric surgery or Meckel's diverticulum was present. The bezoar was successfully milked past the ileocecal valve into the right colon.

Bezoars↗
PubMedDate not supplied

[High-dose oral bacteria-therapy for chronic non-specific diarrhea of infancy].

The Authors evaluate the effectiveness of oral bacteriotherapy using a combination of anaerobe fecal Lactobacilli for chronic non specific diarrhea of infancy. A double blind study was carried out in a total of 40 children treated with low and high doses of bacteria. The results confirm the importance of fecal flora in this disease and support the hypothesis that oral bacteriotherapy can improve clinical and laboratory presentation especially when given at high doses.

Administration, Oral↗
PubMedDate not supplied

[Cow's milk protein intolerance: evaluation of immunological markers. A preliminary study].

Cow's milk protein intolerance (CMPI) is recognised as an important cause of protean symptoms in infants. There are no tests with enough specificity and sensibility to set up a diagnostic assay. We carried out preliminary study on children suffering from CMPI with the following aims: a) to ascertain the importance of the variation in circulating antibodies to cow's milk proteins in CMPI, b) to establish a useful screening tool to diagnose CMPI. Seventy-four subjects (s.) were studied and divided into four diagnostic groups as follows: Six s. (3 M, 3 F) suffering from CMPI mean age 4.8 +/- 3.9 months, assuming a diet containing cow's milk: I group. Eleven s. (O M, 7 F) suffering from CMPI mean age 7.8 +/- 4.6 months, assuming a cow's milk free diet, for several months (mean 4.5 +/- 1.5): II group. Nine s. (5 M, 4 F) suffering from enteropathies not cow's milk correlated, mean age 18.5 +/- 10.6 months, assuming a diet containing cow's milk: III group. Fourty-eight healthy s. (24 M, 24 F), mean age 10.5 +/- 4.3 months, assuming a diet containing cow's milk.(ABSTRACT TRUNCATED AT 250 WORDS)

Caseins↗
PubMedDate not supplied

[Chromium and atherosclerosis].

The authors report numerous experimental and clinical studies relating deficiency of chromium in the organism and atherosclerosis. They hope new researches to compute the pool of chromium in the organism and the validity and possibility to utilize this oligoelement in prevention of atherosclerosis.

Animals↗
PubMedDate not supplied

[Atrophy of the duodeno-jejunal mucosa in cow's milk protein intolerance. Importance of cell-mediated immunologic factors].

Cow's milk sensitive enteropathy has been described several times but in spite of that, it is still a problem concerning the pathogenesis. Our study involves the children hospitalized from 1974 to 1984 in the First Department of Pediatrics, University of Modena. Patients were suffering from chronic diarrhea and malabsorption. At the first biopsy each child showed atrophy of the small intestinal mucosa. All patients had been fed fed with gluten. We have followed the protocol for Celiac Disease's diagnosis; we found proved 85% of cases, excluded 15%. These last cases may be considered as cow's milk sensitive enteropathy. We catamnestically considered all the clinical and laboratory data of the two groups in the purpose of selecting significative parameters for a differential diagnosis. The data meaning fully different between the two groups resulted: family history of allergy, recurrent infections, positive occult blood in the stools, eosinophils in blood greater than 400/mm3 serum IgE value greater than 97 degrees P X (p less than 0.01). On the ground of recent studies the involvement of the cell-mediated immunity in cow's milk sensitive enteropathy is supposed.

Animals↗
PubMedDate not supplied

[Immunostimulating therapy in chronic non-specific diarrhea].

The authors describe 9 children affect by chronic aspecific diarrhea treated with levamisole; the drug was effective in reducing diarrhea episodes during the period of administration in respect to the untreated group. Follow-up of 3-5 months did not show auxological or nutritional differences in the two groups.

Antibody Formation↗
PubMedDate not supplied

[Clinical study on the efficacy of a sustained-release theophylline-based preparation in infants with chronic asthma].

Authors describe 9 infants aged between 3 and 17 months, affected by recurrent episodes of bronchial asthma (at least one crises even month for three following months) and treated with sustained-release theophylline. During the 6 months of follow-up a total of 8 episodes of bronchial asthma in 7 subjects were observed. Seven out of 8 of these episodes occurred during the period of suspension of the therapy with the sustained-release theophylline. In each subjects, after 6 hours from the drug administration on average of 4-8 determinations of the theophylline blood levels were performed. More than 70 percent of the theophylline blood values has been found within the normal therapeutic range (6-20 micrograms/ml).

Asthma↗
PubMedDate not supplied

[Atherosclerosis: a childhood problem].

The project "Precursors of Atherosclerosis (ATS) in Children" following the protocol of WHO started in Modena in 1981/82. A total of 527 schoolchildren of 6, 9, 12 and 15, living in the area around Modena, Emilia Romagna Region, were examined, sampled from whole schools or classes. Each group exceeds the minimum of 100 children with the exception of the group including subjects of 15. The population sampled is fairly homogeneous. There are no immigrants to the area and the intra-population differences due to social-classes are minimal. The standard of life is very high: the rate of income is one of the highest in Italy and the incidence of ATS manifestations is very high. The children will be reexamined each year for three years at the same season and the study will be over in 1984. A questionnaire with family story has been filled by the parents and the parents were directly examined about: height, blood pressure, cholesterolemia, triglyceridemia, smoking habit. Following the protocol in each child are determined: height, weight, Quetelet's index (kg/m2), skinfold thickness, blood pressure, cholesterolemia, triglyceridemia, sexual maturity and smoking habit. The statistical elaboration methods of data are chosen in cooperation with the "Centro di Calcolo" of the University of Modena, and elaborated with the Statistical Package for the Social Science (SPSS) method.

Adolescent↗