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Biomedical subjects

P Beyne

Publications and source records attributed to P Beyne.

27 records · Page 2Linked to original sources
PubMed1985

Is there a treatment necessity for lipid disorders of uremic patients?

In the present review, the role of lipid disturbances is evaluated as a risk factor in the pathogenesis and the potential acceleration of atherosclerosis in uremic patients undergoing long-term hemodialysis. The alteration in high density lipoprotein composition with a decrease in high density lipoprotein cholesterol but a normal apoprotein AI content may have relevance to the atherogenetic process. Moreover, the accumulation of cholesterol-rich, very low density lipoproteins and intermediate density lipoproteins may play a major role in atherosclerosis since these degradation products of triglyceride-rich particles are considered as atherogenic. The hypothesis should be tested whether a correction of the abnormal catabolism of triglyceride-rich lipoproteins in uremic patients leads to a decrease in ischemic vascular events.

Animals↗
PubMed1985

Comparison of several atherogenicity indices by the analysis of serum lipoprotein composition in patients with chronic renal failure with or without haemodialysis, and in renal transplant patients.

We investigated serum lipoproteins in uraemic and kidney transplant patients, and compared the results with those from normal persons. In uraemic patients, with or without haemodialysis, and in kidney transplant patients, the ratio of HDL-cholesterol to total cholesterol minus HDL-cholesterol, the ratio of HDL-phospholipids to total phospholipids minus HDL-phospholipids, and the ratio of apolipoprotein A to apolipoprotein B are all decreased, though to different extents, when compared with healthy control subjects. Furthermore, important differences exist in the relative HDL composition between the 3 patient groups and healthy control subjects. Thus, the ratio of apolipoprotein A/HDL-cholesterol and that of HDL-cholesterol/HDL-phospholipids are significantly altered in uraemic haemodialyzed patients, while the ratio of apolipoprotein A/HDL-phospholipids is normal. By contrast, the 3 ratios are normal in uraemic undialyzed patients, and the 2 ratios, apolipoprotein A/HDL-cholesterol and apolipoprotein A/HDL-phospholipids are normal in renal transplant patients. The last ratio, HDL-cholesterol/HDL-phospholipids, is increased in this group of patients. Thus, it appears that HDL-cholesterol, HDL-phospholipids, and total apolipoprotein A represent different aspects of the same lipoprotein. The determination of all three parameters could lead to a different approach in the evaluation of the so-called cardiovascular risk, at least for uraemic patients and renal transplant patients.

Arteriosclerosis↗
PubMed1985

[Mathematical approach to bacterial identification].

The identification of Enterobacteriaceae is examined in the context of the recent field of research assisted by multi-criteria decisions. In particular, the authors discuss the limitations of two approaches of assisted identification based on completely different mathematical concepts: the calculation of the probabilities (used in commercial centres) and the aggregation of pre-orders by a model of assisted decision such as Electra II. In order to reduce the errors of interpretation inherent in the use of any model, the authors propose the use of computer assisted systems of bacterial identification in bacteriology laboratories.

Bacteriological Techniques↗
PubMed1985

[Effect of metabolic control on plasma lipids and lipoproteins in insulin-dependent diabetes in children and adolescents].

Plasma triglycerides, total cholesterol, phospholipids, HDL-cholesterol, HDL-phospholipids, apolipoproteins A-I and B, haemoglobin AIc and C-peptide were measured in 113 children and adolescents (49 males and 64 females) with insulin-dependent diabetes. These patients were divided into four groups according to sex and age (more or less than 12 years old) and into three subgroups according to metabolic control. In female adolescents with poor control, triglycerides and apolipoprotein B were increased whereas HDL-cholesterol, HDL-phospholipids and (HDL/LDL + VLDL)-cholesterol were significantly decreased. In poorly-controlled male adolescents, similar changes were observed except for HDL-cholesterol and HDL-phospholipids which were not significantly decreased. In adolescents, haemoglobin AIc correlated directly with triglycerides, total cholesterol, phospholipids, apolipoprotein B and inversely with HDL-cholesterol, HDL-phospholipids and (HDL/LDL + VLDL)-cholesterol. In children aged less than 12 years, no significant change of HDL-cholesterol or apolipoprotein B was observed even in the poorly-controlled group.

Adolescent↗
PubMed1983

[Acute respiratory and circulatory failure. Prognostic value of plasma fibronectin levels].

Plasma fibronectin (FNp) concentrations were measured in 63 patients with acute respiratory failure and 28 patients with circulatory failure, using Laurell's electroimmunoassay method. Measurements were made in the acute phase and repeated in the course of the disease. The mean FNp concentration in 20 controls was 262 +/- 59 mg/l. FNp values were normal in the acute phase of chronic obstructive pulmonary disease and in cardiogenic pulmonary oedema. In contrast, they were significantly decreased in adult respiratory distress syndrome and in acute pneumonia, as well as in acute circulatory failure, notably from septic shock. FNp values were also considerably reduced in patients with severe disseminated intravascular coagulation syndrome. Clinical improvement was accompanied by a return to normal of FNp concentrations. The mortality rate was greater in patients with low FNp values than in those with normal values.

Acute Disease↗