Biomedical subjects
Publications and source records attributed to P Bilek.
Prompted by the development of the lightweight, inexpensive and simple to use dermatoscopy, skin surface microscopy can now be applied in daily practice. The case reports presented here document the diagnostic improvement achieved with dermatoscopy in pigment skin lesions of children.
The poor prognosis of thick malignant melanomas emphasizes the importance of their early detection. Skin microscopy using a stereomicroscope has been shown to increase the accuracy of clinical diagnosis significantly in pigmented skin lesions. Owing to the development of the Heine Delta 10 dermatoscope, skin microscopy has become less difficult and more rapid. Therefore, this technique can now be applied routinely in daily office practice.
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The DNA index and proliferation rate (percentage of S-phase cells) of 52 head and neck tumours were analysed by flow cytometry. Thirty-one (60%) of these tumours were aneuploid, 21 (40%) diploid. The distribution of aneuploid tumours was nearly equal in all T-stages. In contrast, the number of aneuploid tumours increased with higher N-stages. Locoregional recurrences developed more often (69%) in aneuploid tumours than in diploid tumours (54%). Furthermore, recurrence presented earlier (median 5 months) than in the latter (median 11 months). Regional recurrences were mainly observed in aneuploid tumours, local recurrences in diploid tumours.
The DNA index and proliferation activities were determined by flow cytophotometry in 59 tumors of the head and neck area. 35 tumors (59%) were aneuploid, 24 (41%) were diploid. Aneuploid tumors showed a tendency to increased formation of lymph node metastases, an increased risk of relapse as well as a shorter relapse-free interval. No correlation was found between the primary tumor stage and the incidence of aneuploid tumors. Whereas aneuploid tumors developed frequently regional recurrences, only local recurrences were observed in diploid tumors. A number of biopsies was additionally performed during radiotherapy in twelve tumors. After 10 or 20 Gy, aneuploid tumors showed a considerably increased number of S and S2 + M phase cells. In diploid tumors, substantial modifications of the cell cycle phases were not found, because it is not possible in these cases to distinguish between normal cells and tumor cells.
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