Biomedical subjects
P Blomquist
Publications and source records attributed to P Blomquist.
Effect of diverting colostomy on collagen metabolism in the colonic wall. Studies in the rat.
The effect of total bowel rest by colostomy on collagen metabolism was studied. Fecal diversion led to a marked decrease of collagen and protein synthesis in the excluded colon. These changes were accompanied by a decrease in the amount of collagen and noncollagenous components. In the colonic part proximal to the colostomy site, a less marked decrease in collagen content was observed. It was concluded that stimulation of intraluminal bulk might be important as a regulating factor for collagen turnover. It remains to be determined if the observed changes in collagen metabolism affect colonic healing.
Effect of diverting colostomy on breaking strength of anastomoses after resection of the left side of the colon. Studies in the rat.
In the present investigation, the effect of a proximal diverting colostomy on suture holding capacity and on anastomotic strength of the excluded left colon was studied. Suture holding capacity was increased 7 days after fecal diversion. Anastomotic strength development, however, was significantly delayed. These differences were accompanied by a diminished collagen response in the anastomotic region after fecal diversion. This might suggest impairment of healing in the excluded colon. The gross appearance of the anastomoses would, however, indicate that increased collagen formation and greater strength development in animals without colostomy is a result of more complicated healing.
The effect of relative bowel rest on collagen metabolism and suture holding capacity in the colonic wall. Studies in the rat.
In a previous experimental study it was shown that bowel rest with low residue diet led to a reduction of the non-collagenous substances in the intact, unoperated colon, while the collagen content remained unchanged. In the cecum, both the collagen content and the non-collagenous substances were markedly increased. In the present investigation the effect of relative bowel rest on collagen synthesis in the colonic wall was studied. Further, a possible influence on mechanical properties was evaluated. It was found out that bowel rest led to a marked decrease of collagen and protein synthesis in the colon. In the cecum, there was an unchanged collagen synthesis but an increased protein synthesis. It can be deduced that lysis of collagen is decreased in all parts of the colon. The depression of collagen turnover in the colonic wall was not accompanied by measurable changes in mechanical strength. It remains to be studied whether the observed changes in collagen metabolism do affect colonic healing.
The effect of relative bowel rest on collagen in the colonic wall. Studies in the rat.
In previous studies it was shown that diminished colonic content pre- and postoperatively, obtained by feeding rats low residue diet, results in less marked postoperative disturbances in collagen metabolism than in animals fed standard laboratory diet. In the present investigation the effect of relative bowel rest on collagen content and collagen concentration in the intact colonic wall was studied by feeding unoperated rats low residue diet. It was found that the colonic and cecal contents were reduced significantly and that this primarily affected the non-collagenous substances in the colon with a marked decrease, while the collagen content was unchanged. In the cecum, both the collagen and the non-collagenous contents were significantly increased. Thus, the pattern of change in biochemical response varied in different parts of the large intestine after institution of bowel rest. Further, the present data imply that collagen concentration can be misleading as a measure of the actual collagen amount.
Herniographic appearance of contralateral inguinal hernia.
In 303 adults (185 men, 118 women) with unilateral groin pain and a normal physical examination, positive contrast herniography was performed. In 32 per cent of the patients a symptomatic hernia (ipsilateral) and in 18 per cent an asymptomatic hernia (contralateral) were found. The type of hernia was indirect, direct, femoral or obturator. Indirect and direct inguinal hernias were significantly more frequent on the ipsilateral side compared with the contralateral in men with right-sided groin pain. In women with left-side groin pain femoral hernias were significantly more frequent on the ipsilateral side compared with the contralateral. The size alone could not discriminate between ipsi- and contralateral hernias. The results indicate that in most patients there is no specific radiographic appearance which can discriminate between symptomatic and asymptomatic hernias.
Herniography in patients with clinically suggested recurrence of inguinal hernia.
In order to assess the diagnostic effectiveness of herniography in patients with pain in the groin, 49 patients who had been operated upon earlier for inguinal or related hernias in the groin were examined. The patients' history suggested the presence of recurrent hernia but physical examination was inconclusive. In 17 patients herniography revealed one or two hernias on the side of the symptoms: 2 indirect hernias, 9 direct hernias, 1 with both direct and indirect hernias, 1 with a combined hernia, and 4 femoral hernias. An incisional hernia was detected in 2 patients. Eleven of the 17 patients were operated upon. The results indicate that herniography is valuable in the follow-up of patients with possible recurrent inguinal hernia.
The effect of relative bowel rest on healing of colonic anastomoses. Breaking strength and collagen in the colonic wall following left colon resection and anastomosis in the rat.
The breaking strength of anastomoses in the left colon in the early phase of healing was studied in rats fed low residue diet (Biosorbin MCT) and the results were compared to those from rats fed standard laboratory diet. Further, eventual correlation between mechanical strength development and collagen content in the colonic wall around the anastomosis was evaluated. The anastomotic strength with sutures in place decreased by approximately 30% of the immediate postoperative value during the first two days in both groups of animals. There was no correlation between changes in anastomotic strength and collagen content at that time. After the second day there was a gradual increase of anastomotic strength, reaching the strength at day 0 after 7 days. The regain of strength was mainly due to collagen deposition in the anastomosis. Despite more collagen deposition in animals on standard laboratory diet the anastomoses had comparable strength development in the two groups. It was concluded that low residue diet does not impair the suture holding capacity or the anastomotic strength. Instead there was some evidence for a more uncomplicated healing when the bowel content was diminished.
The effect of relative bowel rest on healing of colonic anastomoses. Collagen synthesis and content in the colonic wall after left colon resection and anastomosis in the rat.
Collagen metabolism was studied in the colonic wall of rats after standardized resection and anastomosis. Diminished faecal loading was obtained by feeding rats low-residue diet (Bisorbin MCT). The postoperative increase of collagen synthesis and collagen content was on a lower level in these rats than in rats on standard laboratory diet. The increase was confined to the immediate anastomotic region and presumably represented changes in collagen caused by the operative trauma per se. It was concluded that the intraluminal content is an important factor in stimulating collagen turnover. The findings of lower collagen turnover in the anastomotic area in animals on low-residue diet may have positive significance, but could also imply impairment of healing. For elucidation of this question, studies on mechanical strength of the anastomosis are necessary.
Positive contrast herniography in adult patients with obscure groin pain.
To evaluate its clinical benefit in adults, herniography was used in 73 patients with clinically unexplained groin pain. Hernias were demonstrated on the side with symptoms in 26 patients (36%). Relief of groin pain was registered in 16 of 17 patients who subsequently underwent operation. We consider herniography to be of value in the examination of adult patients with clinically unclear groin pain.
Adenoid cystic carcinoma of the breast. Report of a case in a male and review of the literature.
Explore the source record for details and available documents.
The effect of stenosis on collagen metabolism in the colonic wall. Studies in the rat.
The influence of colonic stenosis resulting in faecal loading was investigated in regard to collagen metabolism in the intact colonic wall. The collagen content was increased in the left colon proximal to the stenosis, due to enhanced collagen synthesis. The collagen concentration fell significantly, however, as noncollagenous substances increased more than collagen. Collagen concentration clearly can be misleading as an indication of the actual amount of collagen. The enhanced rate of collagen turnover with collagen accumulation proximal to stenosis requires further analysis in regard to its importance for healing capacity.