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P Bojić

Publications and source records attributed to P Bojić.

28 records · Page 2Linked to original sources
PubMedDate not supplied

[Mastocytes in chronic inflammation of middle ear mucosa].

INTRODUCTION: Pathohistological studies have shown that in secretory otitis media an increased number of mast cells have been found in mucosa of the middle ear and an increased level of histamine in the cavity of the middle ear. The aim of this study was to analyse the distribution and functional state of mast cells in middle ear mucosa biopsies in patients with chronic otitis media. MATERIAL AND METHODS: The pathohistological analysis was performed on 118 biopsy specimens of mucosa of the middle ear. The samples were taken intraoperatively from 39 patients during the surgical treatment of chronic otitis media with and without cholesteatoma and otomastoiditis. The specimens were taken from mastoid, attic space, promantory and protympanon. All biopsy specimens were prepared for hematoxylin-eozin staining and were identified with PAS method and Lennert Giemsa histamine granules. The Alcian blue-Safranin method was used to identify heparin granules in mast cells. By using the semiquantitative method, distribution of mast cells was marked as rare (+), numerous (+2) and high (+3). Also the number of degranulated cells was identified (Tables 1, 2). RESULTS AND DISCUSSION: The analyses of biopsy specimens of mucosa of the middle ear in chronic otitis media showed that cells were present in all areas of mucosa in a considerably higher number (Table 1). Degranulated cells were frequently found in biopsy specimens of otomastoiditis and contained predominately histamine granules; thus specimens taken from chronic otitis media, with and without cholesteatoma, showed mast cells with heparin granules with low rate degranulation. Pathophysiological examinations of the role of mast cells in the mechanism of chronic inflammation have shown that mast cells display through mediators the biphasic effect. They can participate in the process of deterioration of inflammation, whereby the released mediators cause the processes of tissue destruction, and can stimulate the process of tissue repair. Heparin accelerates the healing process of tympanic membrane perforation, stimulates the proliferation of endothelial cells and supports angiogenesis in the lamina propria of the tympanic membrane. Further studies are needed to clarify the role of histamine and heparin in the pathophysiology of chronic inflammation in chronic otitis media.

Adolescent↗
PubMedDate not supplied

[Histological changes of radicular cyst epithelial lining due to chronic inflammation].

The paper deals with the investigation of the relationship between chronic inflammation in the subepithelial layer and histological changes of the epithelium of radicular cysts. Histological examination of 60 radicular cyst specimens was carried out with the aim to define this relationship. The stratified squamous epithelium with a variety of histological changes was found in 58 specimens. A high degrees of chronic inflammation in the subepithelial layer was also recorded. Histological changes of the epithelium correlated to the degree of inflammation in the subepithelial layer of radicular cysts.

Humans↗
PubMedDate not supplied

[Incidence of lymphoma cells in the bone marrow and peripheral blood in patients with non-Hodgkin's type lymphoma].

The appearance of lymphomatous cells in the bone marrow and peripheral blood in 120 patients with Non-Hodgkin's lymphomas (NHLs), was investigated. The presence of lymphomatous cells in the bone marrow was found in 56.6% ob patients and in the peripheral blood in 23.3% of individuals. Lymphomatous site in the bone marrow was proportionally frequent in the group of patients with the high grade aggressive NHLs in comparison to the low grade group. The finding of the peripheral blood occupation was reversible However no significant statistical difference was found. The results also suggest that lymphomatous invasion of the bone marrow does not obligatory predict the invasion of the peripheral blood. Reverse correlation between the frequent bone marrow and peripheral blood occupation by lymphomatous cells and the mean survival time which was significantly shorter in the patients who exhibited the invasion of any kind, was also found. This means that lymphomatous invasion of the bone marrow and peripheral blood might be a potentially useful parameter of the clinical aggressiveness and the course of the disease.

Bone Marrow↗