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Biomedical subjects

P Boldrini

Publications and source records attributed to P Boldrini.

At least 19 recordsLinked to original sources
PubMed2001

One case of immunotactoid glomerulopathy: morphological-ultrastructural aspects.

Starting from a group of 736 renal biopsy patients, evaluated by ultrastructural studies over a period of 22 years, the authors present a rare case of immunotactoid glomerulopathy, suggesting that these forms, until a few years ago considered in the same group as fibrillary glomerulonephritis, are in fact a separate entity; moreover, they may represent a very early manifestation of plasmacellular dyscrasia still at the initial stage.

Fatal Outcome↗
PubMed1998

Histologic findings and Helicobacter pylori in duodenal biopsies.

We have studied the morphologic aspects of the duodenal bulb in relation to Helicobacter pylori infection in a large group of patients with endoscopically assessed duodenitis to learn more about the pathogenesis of nonspecific duodenitis (bulbitis) and to clarify the specific role of H. pylori. Eight duodenal biopsy specimens in the four quadrants of the first part of the bulb and four gastric antral biopsy specimens were taken in 208 patients. Specimens were fixed in formalin, or in glutaraldehyde, then slides were stained with hematoxylin and eosin, periodic acid-Schiff, and Alcian-Giemsa, and with toluidine blue for semithin sections. Duodenal histology revealed inflammation in 155 (74.5%) and H. pylori-like bacterial bodies in 153 (73.5%) of the patients; H. pylori infection in the gastric antrum was diagnosed in 173 (83.1%) of the patients. Distinguishing histologic aspects appeared to be related to the presence of H. pylori infection. We believe that the present histologic grading of duodenitis correlates better with the natural history of H. pylori infection in the duodenal bulb, and better fits the requirements of a modern classification than the classification commonly used in duodenitis. We conclude that the term H. pylori-linked bulbitis should be adopted as the proper term to identify the particular kind of duodenitis predisposing to peptic ulcer.

Adolescent↗
PubMed1997

Localised proton MR spectroscopy of brain metabolism changes in vegetative patients.

We examined 14 vegetative brain-injured patients with proton magnetic resonance single-volume spectroscopy (1H MRS) at 1.5 T to establish whether there were changes in relative concentrations of N-acetyl aspartate (NAA), choline (Cho) and creatine (CR) metabolites from those found in healthy brains. Spectra were obtained from two different (2 x 2 x 2 cm) volumes of interest in the left and in the right frontal cortex, normal on MRI. All spectra revealed abnormalities compared with normal spectra obtained from age-matched control subjects. Values outside the normal range for at least one of the metabolite ratios were observed in all patients. Cho/Cr was markedly higher and NAA/Cho and NAA/Cr were markedly lower than in the control subjects. At different times six patients regained awareness and the ability to obey commands, and four were re-examined; changes in metabolite ratios were observed, which were different in individual patients. The NAA/Cho ratio reaches statistical significance in discriminating between the patients with a poor outcome (death or prolonged vegetative state) and those who regained awareness; the dividing line appears to be at a value of about 1.6.

Adolescent↗
PubMed1993

Ultrastructural patterns of Helicobacter pylori.

Ultrastructural morphology of the bacterial bodies was studied in 40 Helicobacter pylori positive cases. Two bacterial patterns were identified, which were associated with different modes of contact with the epithelial cells and possibly with different stages of the natural history of the infection.

Bacterial Adhesion↗
PubMed1992

Partial hemispheric disconnection syndrome of traumatic origin.

A patient presented left-sided apraxia, constructional disturbances with the right hand and left tactile anomia after a severe head injury. MRI showed a callosal lesion involving the middle and posterior third of the truncus. This finding supports the thesis that the posterior callosum plays a predominant role in the interhemispheric mediation for praxis, as well as in the right-left transfer of spatial information guiding constructional performance. Left-sided apraxia was evident on imitation, on verbal command and on visual presentation of an object, but not on tactual presentation and during the actual use of objects. Moreover, apraxia on imitation showed a more rapid recovery than apraxia on verbal command. These data are consistent with the hypothesis of a left-hemisphere dominance for praxis, which is almost absolute when the retrieval of the appropriate gesture requires a semantic analysis of the stimulus.

Adult↗
PubMed1991

Sexual changes in hemiparetic patients.

Eighty-six patients, each with hemiparesis caused by a single stroke, were studied to assess the changes in sexual life experienced after the onset of the illness. Clinical data were collected, and a questionnaire concerning both sexual behavior and feelings about sexuality was administered to the patients and their spouses. Twenty-four couples were eliminated from further analysis because of a discrepancy between husband and wife in the answers concerning sexual behavior after stroke. A marked decline in sexual activity after stroke was found in both genders; other aspects of sexual behavior underwent fewer changes. The feeling of an overall change in sexual life was reported more frequently by male patients. Most patients' spouses reported the feeling of an overall psychological change in their partners and the feeling of an overall change in sexual life after the onset of the illness. No significant associations were found between clinical features and changes in sexual life. This study confirms that cerebrovascular accidents are generally followed by some important alterations in sexual life. Clinical factors do not seem to play a crucial role in determining these changes, which may be better explained in terms of maladjustment attributable to psychologic and interpersonal factors.

Attitude to Health↗
PubMed1989

Biofeedback treatment of genu-recurvatum using an electrogoniometric device with an acoustic signal. One-year follow-up.

The aim was to evaluate the effect of a biofeedback electrogoniometer in the control of recurvation of the knee while walking in patients with neurological diseases. Eighteen patients were trained daily for 12.8 sessions on average with an electrogoniometer attached to the knee, which gave a signal at a threshold value of 180 degrees in order to avoid hypertension of the knee. The improvement was statistically significant even after one year.

Acoustic Stimulation↗
PubMed1984

Proteolytic activity and calcium concentration in muscle wasting conditions.

The Authors studied the role of proteolytic activity in specimens from denerved and dystrophic human muscles. The Calcium ions concentration was determined in the same samples, for evaluating the possibility of a correlation between these parameters. A significative increase in proteolytic activity was demonstrated for denerved and dystrophic muscles. Calcium ion's concentration was decreased in atrophic muscles compared to controls. No correlation was possible between the two parameters.

Biopsy↗
PubMed1983

Acute cerebrovascular insults in homozygous beta-thalassaemia: a case report.

Neurological complications following vascular thrombotic crises are frequent and occur in sickle cell anaemia and its variants, but are less well recognized in thalassaemias. A case of beta-thalassaemia major is reported complicated by an ischaemic lesion involving the right cerebellar hemisphere. The probable pathogenesis is considered and the literature on the matter briefly reviewed. In agreement with other reports, the interference of risk factors provided by or occurring in association with multiple blood-transfusions is hypothesized. Consequently, caution is recommended in giving large blood-transfusions to thalassaemic patients.

Adult↗
PubMed1983

Pure "aphasic" agraphia due to damage of the left superior parietal lobule.

A case of pure agraphia, due to an ischaemic lesion of the left superior parietal lobule, is reported. The neuropsychological analysis of writing performances suggests an aphasic nature of this patient's pure agraphia. The authors discuss the role played by diffuse and/or localized brain lesions in writing function, emphasizing that the left superior parietal lobule in man may be crucial for the sensorimotor linguistic integration needed for writing.

Aged↗
PubMed1983

The frequency of multiple sclerosis in Mediterranean Europe. An incidence and prevalence study in Barbagia, Sardinia, insular Italy.

Recent investigations on multiple sclerosis (MS) distribution in Italy, based on relatively small population groups, contradict the current thesis, derived from studies undertaken in populations exceeding 300,000, of a lower spreading of the disease in Mediterranean Europe. Intensive surveys on small populations strengthen the suggestion that Italy is a high-risk area, although MS studies based on prevalence rather than incidence could also be biased by geographic variables making prevalence unsuitable for comparing MS prevalence rates found in different years and/or zones. We report a further epidemiologic study in Barbagia, Sardinia, insular Italy, undertaken both to establish the MS incidence in the last 20 years, and to estimate a new prevalence rate. Based on 31 probable incident cases, the mean incidence per year for the years 1961-1980 was 2.9 per 100,000 (3.2 if age- and sex-standardized to the Italian population). On October 24, 1981, the prevalence per 100,000 was 65.3 (77.9 if standardized to the Italian population). These results confirm that in Barbagia, MS occurs more frequently than expected in a Mediterranean area, and give further support to the idea that MS frequency in Italy is similar to that established for most central and northern European countries.

Adolescent↗
PubMed1981

[Tactile recognition and cognitive tasks. Preliminary results].

In a basic experiment, a tactual recognition task was given to 28 normal blindfolded subjects. The subject were asked to explore the stimuli with the left or the right hand, and to choose out of 4 cavities the target form. Two cognitive concurrent tasks varied in terms of their verbal (left hemisphere) and non-verbal (right hemisphere) attributes were then given to other two groups of subjects (both of 24 Ss) performing the basic task. A consistent right hemisphere advantage was obtained in experiment I. For the non-verbal condition left hand performance was disrupted as well as for the concurrent verbal task condition. These findings were interpreted in terms of brain lateralisation of cognitive functions. For the "verbal" condition the results suggests that in case of a different task difficulties the normal mode of operation of the hemispheres is one of cooperative interaction, affecting, in this case, the hemisphere doing the processing.

Female↗
PubMed1981

Is exogenous lanosterol a micronutrient?

Lanosterol, a precursor of cholesterol, is ingested with human diet and occurs in the body in concentrations exceeding solubility. Flesh of immature animals is a common source of dietary lanosterol, which may form with cholestanol and water an insoluble adjunct, CL-2W. As the latter may contribute to various disorders, exogenous lanosterol should be avoided by diet adjustment.

Animals↗