Biomedical subjects

P Boroń

Publications and source records attributed to P Boroń.

At least 19 recordsLinked to original sources

PubMed1991

[Incidence of so-called hepatic failure syndrome in relation to infection with hepatitis B virus (HBV) in epidemiological and environmental studies of the rural population in the Suwałki and Białystok regions 1978-1990].

In years 1979-1991 has been analysed the selected health epidemiological indices is related with liver pathology and viral hepatitis B infections in rural population of Białystok region. In 11,086 analysed persons of an agricultural sector the frequency of antigenemia HBs (0.25-2.5%) was higher that in control groups of urban populations (0.3-0.6%). In 12 years time period observation of chronic hepatopathy syndrome, demonstrated the increased tendency with parallel pathologic increased values of serum A1AT activity and with increased tendency of HBs antigenemia.

Adolescent↗

PubMed1991

[Risk of development of hepatitis B virus infection among alcoholics].

The frequency of incidence of positive serological markers of hepatitis B virus infection among a population of alcoholics in the region of Białystok has been analysed. It was demonstrated that the highest frequency of detection of hepatitis B virus infection appears in a group of patients with post-alcoholic liver cirrhosis (60 percent). Acute virus hepatitis of the B type in alcoholics is characterised by a tendency towards retarded seroconversion of HBe antigen to HBe antibody with a subsequent development of chronic infection and liver cirrhosis.

Alcoholism↗

PubMed1991

[Epidemiology of intra-marital infections with hepatitis B virus (HBV) among the patients hospitalized in the infectious disease clinics in the Białystok region 1988-1990].

Viral hepatitis B infection is worldwide epidemiological and clinical problem with same prophylactic difficulties concerned first of all married patients. The infection routes could be parenteral or homo/heterosexual contact. During 1988-1990 from hospitalized viral hepatitis B all patients (394), married patients was found 9% (34) persons with epidemiological documented viral hepatitis B infection, from his/her sexual married partner.

Adult↗

PubMed1990

[Immune modulating effect of isoprinosine in patients with post-alcoholic liver cirrhosis].

Immunomodulating effect of isoprinosine was estimated in group of 10 patients with postalcoholic liver cirrhosis and compared with another group of 10 patients with postinflammatory liver cirrhosis with infection of hepatitis B virus. Disturbances of immunologic reactivity in the patients with postalcoholic liver cirrhosis mainly concerned increased immunoglobulin G, A concentrations in the blood serum, decreased percentage values of lymphocytes T and their subpopulations (lymphocytes T4 and T8) and increased percentage of lymphocytes B. Disturbances of the examined indices of the immunologic reactivity in the group of patient with postinflammatory liver cirrhosis concerned increased concentrations of circulating immunologic complexes, immunoglobulins A and M in the blood serum and decreased percentage of lymphocytes T and their subpopulation. Treatment with isoprinosine resulted in different immunologic effect in the examined patients concerning mainly increased concentrations of circulating immunologic complexes in the blood serum and increased percentage values of lymphocytes T, T4, T8, B in the course of postalcoholic liver cirrhosis. Patients with postinflammatory liver cirrhosis treated with isoprinosine mainly showed decreased concentrations of circulating immunologic complexes, immunoglobulins A, M the blood serum, increased percentage values of lymphocytes T4 and T8.

Adult↗

PubMed1990

[Primary liver cell carcinoma among the population of Białystok in 1975-1988 in relation to hepatitis B virus infection].

In presented study, retrospective epidemiological analysis was performed in 84 patients dead due primary hepatocellular carcinoma, selected from among 17,973 persons dead in Białystok hospitals from 1975 till 1988. In the part from among these patients was estimated prevalence of serological markers of Hepatitis B virus infection, as a potential oncogenic factor. Analysis of this carcinoma diagnosis frequency in particular years showed rising tendency: from 1975 till 1979 number of PHC diagnosis was from 0 to 5 a year, whereas in 1988 it was 13. Percentage of necropsy diagnosed PHC was similar and increased to over 1% of all necropsies in 1988. Mean age of patients dead due PHC was 65, and 71.4% were men. Serological markers of HBV infection were observed in 50% and HBsAg in 34.6% from among PHC-dead patients. These percentage values were significantly higher, than observed in control group of Białystok population, which indicate possibility of association between HBV infection and PHC development.

Adult↗

PubMed1990

[Morphological studies of the effects of protein-free diet and branched-chain amino acids (aminosteril-hepa (Frasenius)) on experimental thioacetamide-induced liver damage].

The studies were performed in two groups of rats in which experimental hepatic encephalopathy was induced with tioacetamide++. One group of rats on protein-free diet was given intraperitoneally a mixture of amino-acids (Aminosteril-Hepa), the other one was given proteins in the diet in a dose 1 g per kg of body weight. Histological and histochemical studies revealed that free-protein diet with a mixture of aliphatic polybranched amino-acids (Aminosteril-Hepa) inhibited hepatotoxic thioacetamide+ action on the rat liver.

Amino Acids↗

PubMed1990

[Effect of differentiated diet therapy on the clinical results and biochemical indicators in chronic hepatic encephalopathy].

Effects of differentiated diet with reduced proteins or diet without proteins with simultaneous use of lactulose or the preparation enriched with aliphatic amino acids with aminosteril-hepa chain on the clinical results and the ammonia, phenols, alpha-amino nitrogen, tyrosine, phenylalanine and tryptophan++ concentrations in the serum have been studied. It has been demonstrated that limitations of proteins in the diet or diet without proteins with the use of lactulose or amino acids mixtures above does not influence significantly the clinical amelioration or biochemical indices of encephalopathy or coma during the liver cirrhosis course. Homogenates of the liver and brain of patients who died due to encephalopathy and liver cirrhosis showed high contents of ammonia, tyrosine, phenylalanine and tryptophan++.

Amino Acids↗

PubMed1989

[Pneumocystis carinii pneumonia and AIDS].

An infection with Pneumocystis carinii with clinical symptoms of pneumonia is particularly frequent in patients with AIDS. The authors discuss current knowledge on Pneumocystis carinii pneumonia, including clinical course, possibility of diagnosis, and chemotherapy in patients with AIDS.

Acquired Immunodeficiency Syndrome↗

PubMed1989

[Studies of the effect of a protein-free diet and branched-chain amino acids (preparation Aminosteril-Hepa) on selected biochemical indicators in chronic experimental hepatic encephalopathy].

The latest observations suggest that a decreased level of serum branched-chain amino acids plays a role in the pathogenesis of liver encephalopathy. In this study we analysed the behaviour of the serum concentrations of: ammonia, phenols, alpha-amino nitrogen, tyrosine, phenylalanine and tryptophan in rats with thioacetamide-induced liver encephalopathy. The first group of rats was on protein-free diet and Aminosteril-Hepa (Fresenius FRG)--an amino acids solution with predominance of branched-chain amino acids. The second group of rats received a diet with 1 g/kg b.w. of protein daily. The levels of biochemical indices were analysed 0, 3, 5 and 7 days after liver encephalopathy development. The results of our study indicate a favourable influence of infusion a branched-chain amino acids solution (Aminosteril-Hepa) on the biochemical indices, particularly phenols and alpha-amino nitrogen in experimental liver encephalopathy.

Amino Acids↗

PubMed1989

[Some indices of organism reactivity in chronic trichinellosis].

Sixty four patients who had passed the acute phase of trichinellosis 3, 4, 5 and 8 months and 1, 2 and 4 years earlier, have been examined with respect to their clinical condition, persistence of possible subjective complaints which could be associated with the acute phase passed, leucocytosis, absolute number of acidophilic granulocytes in blood, indices of immunological response, both humoral (IgG, IgA and IgM) and cellular (percentage of T and B lymphocytes in blood), serotonin level in blood, monoamino-oxidase activity in blood serum and passive hemagglutination reaction with trichinellosis antigen. It has been found that the frequency of occurrence and intensity of subjective complaints decreases with time. Changes in humoral and cellular reactivity, and long-lasting persistence of antibodies against the trichinellosis antigen, determined with passive hemagglutination method, have been also observed in particular patients.

Adolescent↗

PubMed1988