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P Boutte

Publications and source records attributed to P Boutte.

35 records · Page 2Linked to original sources

[Pregnancy, diabetes and the insulin pump. A better prognosis?].

The fetal prognosis in pregnancy in a diabetic woman depends mainly on the blood sugar equilibrium of the mother that can be obtained, since the normal range lessens the chances of fetal abnormalities. This has been demonstrated in this series, since a system that uses the continuous automatic administration of insulin has been used. Six diabetic women were treated with continuous subcutaneous perfusion of insulin in the second half of pregnancy. The quality of the maternal blood sugar equilibrium has been proved by the normal values of glycosylated haemoglobin and the values of venous blood sugar which were always within the mean of the normal range. The tolerance of the technique is excellent (83 days in mean without a single complication). In 4 out of the 6 cases the baby was born at the 38th week of pregnancy and studies show that there was no increase in weight and a very low level of neonatal hypoglycaemia. It seems desirable to use this kind of insulin therapy which should help to contribute to a better fetal prognosis in diabetic pregnancies.

Adult↗

[Association of hereditary hydrocephalus and holoprosencephaly].

An infant with alobar holoprosencephaly and hydrocephalus is reported. The mechanism of hydrocephalus (aqueductal stenosis) and the mother's previous history (2 boys from a first marriage still-born with hydrocephalus) suggest a X-linked hydrocephalus. The association of a holoprosencephaly with this hereditary hydrocephalus is discussed.

Abnormalities, Multiple↗

[Adaptation of the oral dosage of theophylline to the asthmatic child. Value of a kinetic test by the intravenous route].

The authors propose a practical method for determining chronic oral theophylline dosage in children from slow intravenous theophylline infusion (45 minutes). Calculated clearances and half lifes provided a basis for daily oral theophylline doses and dosing intervals. Pharmacokinetic characteristics (mean +/- SD) in 34 asthmatic children (age range 2-14 years) averaged 0.082 +/- 0.028 l/kg/h for Cl; 0.436 +/- 0.087 l/kg for Vd; 4.07 +/- 1.43 h for t 1/2. Calculated daily dosages necessary to maintain mean serum theophylline concentration of 12.5 mg/l ranged from 9.6 to 40.9 mg/kg/d (average 24.5 mg/kg/d). The validity of proposed dosage schedules is studied in 11 children (among the 34 patients) undergoing a chronic theophylline treatment either with rapid absorption products, or sustained-release form. The difference between predicted and effective serum concentrations was within +/- 1.8 mg/l in all cases.

Administration, Oral↗

[Monosomy 7qter (author's transl)].

A terminal deletion of the long arm of chromosome 7 is identified in a boy observed from birth to age 6 months. Eleven previously reported cases were reviewed. Eleven previously reported cases were reviewed. The most common features are microcephaly with brachycephaly, prominent forehead, large ears, a nose with bulbous tip, overlapping toes, genital abnormalities in the males and excess of subcutaneous tissue. Delayed mental and physical development is a general rule but visceral malformations seem uncommon.

Abnormalities, Multiple↗

[Pneumonia and submaxillary cellulitis caused by B group Streptococcus in an infant].

The association of pneumonia and submandibular cellulitis in the case of group B streptococcal LOD (Late Onset Disease) is rare. Concerning the possible nosocomial infection of a 31/2 months infant the authors compare the pulmonary disease with that of the EOD (Early Onset Disease) and like other authors recommend considering GBS as the main cause of any cellulitis for an infant under 4 months.

Cellulitis↗

[The Vater association in a newborn infant of a diabetic mother].

Concerning the case history of an infant of diabetic mother, the authors analyse the possible relationship between a VATER association and a poorly controlled diabetes mellitus in the early weeks of pregnancy. Caudal regression syndrome, the most frequently observed malformation noted in infants of diabetic mothers and VATER association are the results of an "AXIAL MESODERMAL DYSPLASIA". Furthermore, the factors causing VATER association occur before the seventh week of pregnancy like those responsible for the anomalies observed in infants of diabetic mothers. It is possible that a poorly controlled diabetes mellitus before conception and in the early weeks of pregnancy could favour the appearance of VATER association.

Abnormalities, Multiple↗

[Henoch-Schoentein syndrome following duodenitis with severe denutrition from distal ileum lesions. One case (author's transl)].

A case of Henoch-Schoenlein syndrome in an 8-year old child is described. The cutaneous symptoms appeared 10 days after duodenitis with ulceration of the duodenal bulb. Severe denutrition resulting from lesions of the distal ileum total required parenteral nutrition for 38 days. The anatomo-radiological signs of gastrointestinal manifestations of the syndrome are discussed.

Child↗