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Biomedical subjects

P Bravi

Publications and source records attributed to P Bravi.

4 recordsLinked to original sources

[Polyarteritis nodosa cutanea: a case report].

Cutaneous vasculitides continue to be difficult to diagnose and treat because of the complexity of these disorders. Current classification schemes are based on clinical findings and histopathologic criteria, so biopsy of an early evolving lesion is the most effective means of establishing the diagnosis. We describe the case of a 74 years old man suffering from livedo reticularis and painful nodular lesions, with ulcers, on the legs. Establishing a precise diagnosis has required biopsy of the lesions which showed histopathologic feature of cutaneous polyarteritis nodosa and the designation of cutaneous vasculitis as "isolated" or "primary" was based on lack of systemic disease documented by clinical findings, laboratory tests and instrumental investigations. Remission occurred after moderate doses of steroid therapy and after a year of management with low dose of steroid therapy the patient experienced significant improvement. Cutaneous polyarteritis nodosa is usually a benign disease, however it may relapse, and a long range follow up of the patient is necessary because of the possibility of systemic involvement.

Aged↗

Noninvasive evaluation of cardiac dysrhythmias, and their relationship with multisystemic symptoms, in progressive systemic sclerosis patients.

Fifty-three patients (34 who had diffuse scleroderma, and 19 who had CREST syndrome [calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasias]) were studied by noninvasive procedures, including resting electrocardiogram (ECG), continuous 24-hour Holter ECG monitoring, M-mode echocardiography, and 2-dimensional echocardiography. Only 22 patients (42%) had abnormalities such as conduction defects, supraventricular or ventricular arrhythmias, or ST-T changes detected on resting ECG. In contrast, using Holter monitoring, the number of conduction abnormalities seen increased from 10 to 16 patients and transient ST-T changes increased from 2 to 18 patients. Forty-eight patients had ventricular arrhythmias, with multiform ventricular premature beats in 21 (40%), pairs of runs of ventricular tachycardia in 15 patients (28%), and 1 or more runs of ventricular tachycardia in 7 (13%). Echocardiography detected asymmetric septal hypertrophy in 10 patients, impaired ventricular function in 9 patients, congestive cardiomyopathy in 2, mitral prolapse in 4, and pericardial effusion in 3 patients. Multiform and/or repetitive ventricular premature beats occurred more frequently in patients with echocardiographic abnormalities, but were also present in patients who had normal findings on echocardiographic examination. Cardiac involvement was not correlated with clinical variants of scleroderma (CREST syndrome or diffuse scleroderma), nor with other signs and symptoms of the disease. Thus, cardiac involvement is found much more frequently than would be expected from clinical symptoms or from results of resting ECG alone; therefore, Holter monitoring and echocardiography should be included in the routine workup of patients who have scleroderma.

Adolescent↗

[Use of potassium chloride hypertonic saline solution (3M KC1) for extraction of soluble antigens from Candida albicans].

Soluble antigens have been obtained from Candida albicans cultures of different age treated with hypertonic salt solution (3M KC1). The antigens reached against anti-Candida immune sera in double diffusion agar test, also after adsorption of immune serum on Candida cells. Electron microscopic pictures revealed a marked reduction of the outer layers of 3M KC1 extracted cells.

Antigens, Fungal↗