Use of gastro-omental free flaps in major neck defects.
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Combined Modality Therapy↗
Biomedical subjects
P Breton
Publications and source records attributed to P Breton.
[Patient-controlled exercise therapy in temporomandibular joint pain-dysfunction syndrome].
Self-controlled gymnastics in SADAM relaxes the masticator muscles, allows precise assessment of occlusion and helps the patient acquire occlusion-conscience. The technique is entirely patient controlled.
Dental Occlusion↗
[Late results of the surgical treatment of temporomandibular joint ankylosis in children].
Long-term outcome after surgical treatment of temporomandibular joint ankylosis is not always satisfactory in children. Interposition of a temporalis muscle flap is insufficient to ensure good functional results if the surgical procedure is not followed by careful active and passive physiotherapy. The results can be evaluated only after the child has grown.
Ankylosis↗
[A case of aggressive juvenile fibromatosis of the mandible].
We report a new case of aggressive juvenile fibromatosis (FJA) in a 20 months old girl. It was initially treated by hemimandibulectomy. A secondary reconstruction was performed with a fibular flap at the age of 9 years. FJA is a locally aggressive lesion which does not metastasize. It occurs chiefly in girls during childhood. Radiographs are non-specific (extensive osteolytic lesion). The clinicopathologic diagnosis is discussed with the other mandibular fibrous tumors in children.
Bone Transplantation↗
Immunochemical characterization of antibody-coated nanoparticles.
A new method using surface plasmon resonance (SPR) through the BIAcore was used to demonstrate the specific interaction between an anti-CD4 monoclonal antibody (IOT4a), adsorbed on poly(methylidene malonate 2.1.2) (PMM 2.1.2) nanoparticles, and the CD4 molecule. The results obtained were compared with the interaction of the same immunonanoparticles with rabbit anti-mouse Fc antibodies. The molar ratio (Fc)/(Fab) was 1, suggesting that the same number of epitopes on the Fc and the Fab fragments were accessible after IOT4a adsorption onto nanoparticles. Comparing the observed association rates of free antibody and antibody adsorbed on nanoparticles, the number of molecules of IOT4a antibody on PMM 2.1.2 nanoparticles was estimated as between 2.6 and 3 per nanoparticle. The properties of the antibody-coated nanoparticles are compatible with their use as antibody-targeted pharmacophores.
Adsorption↗
[Do corticotherapy and hemodilution decrease postoperative inflammation after maxillofacial surgery?].
OBJECTIVE: To assess the efficiency of corticosteroids and preoperative acute normovolaemic haemodilution (PANHD) in reducing postoperative inflammation after maxillofacial surgery. STUDY DESIGN: Randomized clinical trial. PATIENTS: Thirty-two patients scheduled to undergo maxillary osteotomy for facial dysmorphia were randomized into four groups of eight (PANHD or not; corticosteroids or not). METHODS: PANHD decreased haematocrit to 30%. In the corticosteroid groups, methylprednisolone 1.5 mg.kg-1 was given intravenously at the beginning of surgery (after PANHD in haemodiluted group), and after surgery, 1.5 mg.kg-1 iv daily for three days. Postoperative inflammation was assessed with an X-Ray technique (radiotelemetry) providing data on tissue thickness (extent of facial oedema), and by measurement of plasma concentrations of four acute phase proteins during the first postoperative week. RESULTS: No change in facial oedema and in acute phase proteins occurred with PANHD. Corticosteroids decreased postoperative oedema and acute phase proteins. CONCLUSION: Corticosteroids decrease postoperative inflammation after maxillofacial surgery but not PANHD.
Acute-Phase Proteins↗
[The Abbe-Estlander flap: anatomic basis, surgical technic and indications for lip repair].
The Abbe-Estlander flap is a full-thickness lip-switch flap rotated from mid lower lip to fill defects of the upper lip. In 1872, Estlander emphasized the importance of this flap. Abbe, in 1898, was the first to switch a lower lip flap into the upper lip for a cleft deformity. The lip-switch flap is an arterialized flap, based on the constant inferior labial artery. This flap is widely used to repair the defects from cancer and traumatism or in repair of the cleft lip deformities.
Cleft Lip↗
[The keratocyst or epidermoid cyst: the current state of understanding apropos of a case with intracranial involvement].
The authors report a case of penetration of an odontogenic keratocyst into the skull base. There is significant controversy about what is the optimum surgical treatment for the odontogenic keratocyst. Diagnosis, mode of growth and recurrence of keratocyst are still a great deal of interest. This paper reports the recent advances in the subject.
Adult↗
[The value of ultrasonographic monitoring in mandibular lengthening using the Ilizarov principle. Preliminary results].
From a review of the literature and a clinical case, we demonstrate the value of ultrasonographic monitoring of mandibular distraction according to the Ilizarov's protocol. Unlike X rays, sonography offers early and reliable pictures of the ossification process. The ultrasonic image matches the histological aspect obtained in the course of experiment. A more accurate monitoring of the regenerating area is thus made possible.
Bone Lengthening↗
Analysis of human CD4-antibody interaction using the BIAcore system.
Interaction between CD4 cell surface protein and HIV-bearing gp120 has been described as the initial step for HIV entry into host cells. Some anti-CD4 antibodies were shown to inhibit this interaction. Biosensor studies using the BIAcore were performed to determine kinetic and thermodynamic parameters of the interaction of one of these antibodies (i.e. IOT4a, clone 13B8-2) with immobilized recombinant soluble CD4 (rsCD4). A non-linear regression method was used to analyze the sensorgrams, showing the existence of a double exponential time curve. A KA of 5.2 x 10(7) M-1 was calculated at 25 degrees C. The complex formation was exothermic (-4.5 kcal.mol-1( and entropically positive (+20 cal.mol-1.K-1). The reaction rate (0.234 x 10(5) M-1.s-1 at 25 degrees C) as well as the enthalpy change of the activated complex (+9.7 kcal.mol-1) are not compatible with a diffusion controlled reaction. The thermodynamic values calculated from equilibrium data corresponded to those calculated from kinetic data confirming the validity of the theoretical approach. As for most antigen-antibody interactions, complex formation was enthalpy driven. The overall positive entropy contribution to the stabilization of the complex is in contrast to that observed for the lysozyme-anti-lysozyme model and is probably due to electrostatic interaction between the epitope and the antibody combining site.
Antibodies, Monoclonal↗
Acute normovolaemic haemodilution does not reduce the inflammatory process induced by facial surgery.
The place of preoperative acute normovolaemic haemodilution (haematocrit = 28%-32%) in reducing postoperative inflammation was evaluated after facial surgery. Thirty-two patients scheduled for mandibular osteotomy were randomized to a nonhaemodiluted group or to a haemodiluted group. The degree of postoperative inflammation was evaluated: first by an x-ray technique (radiotelemetry) providing measurements of the tissue thickness (quantitation of facial oedema), and second by the measurement of four acute phase protein plasma concentrations during the first postoperative week. Throughout the study, no changes in facial oedema or in variation of acute phase proteins were detected after haemodilution. It is concluded that acute normovolaemic haemodilution has no effect on the intensity of facial oedema and the biological inflammation process after facial surgery.
Acute-Phase Proteins↗
Enzymatic properties of the stonefish (Synanceia verrucosa Bloch and Schneider, 1801) venom and purification of a lethal, hypotensive and cytolytic factor.
The crude venom of the stonefish (Synanceia verrucosa) possesses numerous enzymatic properties (hyaluronidase, eight esterases and ten aminopeptidases). Verrucotoxin was isolated by DEAE and hydroxyapatite chromatography, followed by FPLC gel filtration on Superdex 200 HR 10/30. It was found to be a glycoprotein with a mol. wt of 322,000 +/- 2000, comprising four subunits, 2 alpha (83,000) and 2 beta (78,000). Verrucotoxin, as the crude venom, is lethal for mice, haemolyses washed rabbit erythrocytes and induces a fall in arterial pressure in anaesthetized rats.
Animals↗
[The gastro-omental flap: a secreting mucous flap for reconstruction of the oropharynx and the oral cavity].
The gastro-omental flap consists of a patch taken from the greater curvature of the stomach and the bordering omentum. It is based on the right gastro epiploic vessels and is used as a free flap for intraoral reconstruction after resection of oral carcinoma. Twenty patients underwent gastro-omental flap. The operative technique is described. The evaluation consisted in questioning, chemism on the salivary flow and biopsies. There is no morbidity related with the donor site. The gastro-omental flap avoids post irradiation xerostomia. Oral irritation and bleeding of the flap may occur.
Adult↗
Effects of organophosphates on rabbit pyramidal cells firing pattern and hippocampal theta rhythm.
The effects of the irreversible acetylcholinesterase (AChE) antagonist paraoxon (Px) on hippocampal neurophysiology were investigated and compared to those of physostigmine in urethane-anaesthetized rabbits. Hippocampal CA1 EEG signals were analyzed by power spectra. Following intracarotid administration, the two drugs induced a similar fundamental low-frequency theta power peak while the appearance of a second theta harmonic was commonly found under Px. Again, inhibition of CA1 pyramidal cells firing was significantly more pronounced after Px injection than after physostigmine. A potent inhibitory action was also described following local Px iontophoretic application. However, a discrepancy appeared between the effects of Px and the classical cholinergic drugs (acetylcholine, physostigmine). The results indicate that Px and physostigmine have a rather similar influence on the septo-hippocampal pathway and support suggestions that Px could act within local hippocampal circuitry through other systems than the cholinergic system exclusively.
Animals↗
Preparation and characterization of novel poly(methylidene malonate 2.1.2.)-made nanoparticles.
Poly(methylidene malonate 2.1.2.) (PMM 2.1.2.) nanoparticles were prepared in phosphate buffer through emulsion polymerization of monomeric units; the kinetics of the reaction was monitored by spectrophotometry at 400 nm. Average nanoparticle sizes, molecular weights, and biodegradability of this potential drug carrier were determined under various conditions. As previously demonstrated for other similar monomers, i.e. IHCA or IBCA, pH influenced the physico-chemical characteristics of the nanoparticles obtained. Ethanol release from the ester-bearing side chains indicated that the polymers were susceptible to hydrolysis when incubated in basic pH or in rat plasma. A secondary degradation pathway, yielding formaldehyde through a reverse Knoevenagel's reaction, was minimal. Cytotoxicity studies of this new vector, in vitro, against L929 fibroblast cells demonstrated that PMM 2.1.2. nanoparticles were better tolerated than other poly(alkylcyanoacrylate) (PACA) carriers. Pharmacokinetic studies were also carried out to observe the fate of 14C-labelled PMM 2.1.2. nanoparticles after intravenous administration to rats. Forty eight hour post-injection, more than 80% of the radioactivity was recovered in urine and faeces. The body distribution of the polymer was estimated by measuring the radioactivity associated with liver, spleen, lung and kidneys. Five minutes after injection, a maximum of 24 +/- 2% of the total radioactivity was detected in the liver and less than 0.4% in the spleen. The liver-associated radioactivity decreased according to a biphasic profile and less than 8% of the total radioactivity remained after 6 days.
Animals↗
Balance between human peripheral blood CFU-GEMM and CFU-Meg in sustained and acute thrombocytopenia.
Quantitative variations of blood cell progenitors were studied in thrombocytopenic post-chemotherapy patients and in healthy plateletpheresis donors with the aim of better understanding the reasons for their varying presence in peripheral blood. In 6 post-chemotherapy patients with severe thrombocytopenia on days 21-27 after initiation of chemotherapy when white blood cell counts were approximately 2.1-6.0 x 10(9)/l, a balance was observed between the most and least immature progenitors: levels of CFU-Meg were significantly lower than control values whereas levels of CFU-GEMM were 2-fold higher than in controls. Results suggest that an activator distinct from the known poietins may stimulate very immature progenitors. In 15 plateletpheresis donors, numbers of CFU-GEMM and CFU-Meg were greatly increased, respectively 5.5-fold and 10-fold, following plateletpheresis. Data once again indicate a major role of CFU-GEMM in the production of mature blood cells. As the most immature progenitors and thrombocytopoiesis stimulating factor(s) are both present in peripheral blood, such factors may be responsible for the initial engagement of these very early progenitors into a specific cell line.
Acute Disease↗
[Osteotomy of the median tubercule as a consequence of bilateral complete labio-maxillo-palatal cleft].
In the bilateral total labio-maxillary cleft the premaxilla is sometimes very protrusive at the completion of facial growth. This kind of malposition cannot be treated by orthodontics. Surgical repositioning of the premaxilla with simultaneous bilateral alveolar maxillary bone graft is done before the revision of lip and nose. Its goal is the reconstruction of a solid and harmonious dental and maxillary arch, closure of bucconasal fistulas, improvement of facial profile by closure of nasolabial angle. The authors describe the operation technique and illustrate it by two cases.
Adolescent↗
[Giant cysts of the mandible: the value of conservative treatment].
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Adult↗