PubMed Health⌕ Search

Biomedical subjects

P Broulík

Publications and source records attributed to P Broulík.

At least 19 recordsLinked to original sources
PubMed1991

[Dual-photon densitometry of the lumbar spine. Further experience and findings].

The authors submit further experience with two-photon absorption measurement of the mineral content of the lumbar spine using a NOVO/Lab BMC 22a (Denmark) apparatus. 1. The authors discuss the problem of evaluation of results in postmenopausal women. For the basic evaluation the authors use the range +/- 2 s of "normal" values classified by decades; another suitable guide to the interpretation could be extrapolation of the lower range of the regression zone in recorded in premenopausal women to higher age groups. 2. The histogram of frequencies of normal values in women in g.cm-2 has two peaks corresponding to the group of premenopausal women and the group of postmenopausal women. 3. Of 573 examined patients with osteoporosis 295, i. e. 51.5%, cannot be reliably evaluated or cannot be evaluated at all (as a rule because of changes of the spine). Of 49 results obtained in men with osteoporosis 34.7% are within the normal range, of 229 results obtained in women with osteoporosis 47.2% are within the normal range. The hitherto assembled experience is consistent with the view that the method is useful and invaluable in particular for the long-term follow up of patients.

Absorptiometry, Photon↗
PubMed1990

[Hormones in bone metabolism. II. Other systemic hormones].

The authors present a review on a number of systemic hormones involved in bone metabolism. At the same time they demonstrate mechanisms of their action on the cellular, tissue and skeletal level. Attention is drawn to the participation of these hormones in the pathology of bone and other organs and the necessity to protect the skeleton during their therapeutic use in other than osteologic indications.

Adrenal Cortex Hormones↗
PubMed1989

Bone alkaline phosphatase isoenzyme and urinary hydroxyproline in healthy subjects, patients with osteolytic metastases, and patients with primary hyperparathyroidism.

The values of urinary hydroxyproline excretion reflecting the bone remodelling by osteoclasts, and the bone isoenzyme of serum alkaline phosphatase reflecting the osteoblastic function, in 100 randomly selected healthy subjects, 100 patients with primary hyperparathyroidism, and 100 patients with osteolytic secondary tumorous deposits in the skeleton showed a bivariate lognormal distribution. Hotelling's test revealed highly significant differences in the biochemical values among these three conditions, even when Bonferroni's modification of the test was used. The individual biochemical values, however, displayed many mutual overlaps. Despite this, the discriminatory analysis based on bivariate biochemical data resulted in a correct diagnosis in all healthy subjects, in 82 patients with primary hyperparathyroidism, and in 93 patients with osteolytic metastases. The simultaneous determinations of urinary hydroxyproline excretion and the bone alkaline phosphatase insoenzyme improve the differential diagnosis between these conditions. The predominance of urinary hydroxyproline excretion relative to bone alkaline phosphatase isoenzyme suggests an osteolytic metastasis. Proportionately elevated both hydroxyproline and bone alkaline phosphatase isoenzyme indicate the presence of primary hyperparathyroidism. This shows the importance of a correct biometrical processing of data. Nevertheless, a complex clinical evaluation is always mandatory.

Adult↗
PubMed1987

Serum osteocalcin levels and bone alkaline phosphatase isoenzyme after oophorectomy and in primary hyperparathyroidism.

Serum osteocalcin levels peaked 1 yr after oophorectomy in a prospective study of 12 women. Estrogen treatment restored serum osteocalcin to the normal range within 4 months of therapy. The changes in serum osteocalcin preceded those in bone alkaline phosphatase activity by 1-2 months, in these oophorectomized patients and during estrogen treatment. The changes in these two markers of bone formation over time were significantly different from those in urinary hydroxyproline excretion. A significant positive correlation was found between bone alkaline phosphatase and serum osteocalcin levels in patients after oophorectomy and in 18 patients with primary hyperparathyroidism. Significant positive correlations also were found between the biochemical indices of osteoblastic function and urinary hydroxyproline excretion and/or nephrogenous cAMP in primary hyperparathyroidism. In most of the patients with primary hyperparathyroidism, however, the elevation in bone alkaline phosphatase was more marked than that in osteocalcin. These data indicate that the clinical utility of serum osteocalcin as a marker of bone formation is similar but not identical to that of bone alkaline phosphatase.

Acid Phosphatase↗
PubMed1976

Effect of cyproterone acetate on the action and metabolism of testosterone in the mouse kidney.

Cyproterone acetate given alone or in combination with testosterone propionate or 5alpha-dihydrotestosterone to castrated male mice does not exhibit an antiandrogenic action on the kidney. It functions rather as a slightly renotropic hormone, even potentiating the renotropic activity of androgens. The administered amount of cyproterone acetate to intact males or castrates supplemented with androgens, however, decreased dramatically the weight of seminal vesicles and of spleen. Cyproterone acetate treatment of the animals influences in vitro the testosterone to androstenedione conversion but not the activity of 5alpha-reductase in the mouse kidney slices.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗