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P Buranapong

Publications and source records attributed to P Buranapong.

7 recordsLinked to original sources

Lesson learned from Co-60 accident in Thailand.

The causes and consequences of a Co-60 radiation accident in Samutprakarn Province, Thailand, were scrutinized to learn lessons aimed at preventing future radiation accidents. "Orphan sources" may end up in scrapyards. An out-of-use Co-60 medical teletherapy source, left unattended in a disused parking area belonging to a Medical Dealer, was stolen and sold to a scrap dealer in Samutprakarn Province at the end of January 2000. Because of its valuable appearance, a number of workers in the scrap trade who were not aware of radiation hazards managed to dismantle all parts. The Co-60 source was removed and left unshielded among pieces of scrap metal in the yard of the scrap shop. Some workers immediately became sick. Eighteen days later when they went to a local hospital their symptoms were recognized as radiation sickness and the incident was reported to the Office of Atomic Energy for Peace (OAEP) in Thailand. The unshielded source, with an estimated activity of 15.7 TBq (425 Ci), was retrieved soon after by an emergency team and placed in safe storage at the OAEP premises. Ten victims developed radiation sickness symptoms, of which three died soon after the accident. The accident alarmed the public, and has raised national concerns. The accident is similar in some ways to the 1987 radiation accident at Goiania, Brazil, involving a Cs-137 radiotherapy source. If not properly disposed of orphan radiation sources can lead to serious injury or even death. The accident highlights the need for security of spent high activity sources and the importance of regulatory controls.

Cobalt Radioisotopes↗

Thyroid cancer dosimetry using clearance fitting.

UNLABELLED: Since 1962, Memorial Sloan Kettering Cancer Center has used an individually optimized dosimetry method for patients with thyroid carcinoma undergoing radioiodine therapy. This traditional dosimetry method involves a determination of the maximum tolerated activity or the activity that will deliver 2 Gy to the blood (A(max)), and the corresponding ablative lesion dose (D(lesion)). However, the traditional calculations of A(max) and D(lesion) were based on empirical assumptions. The objective of this work was to develop a dosimetry method that eliminates these assumptions by incorporating patient kinetics and that is not restricted to 131I as a tracer and therapeutic agent. METHODS: Patient kinetics were incorporated into the dosimetry algorithm by fitting parameters to patient clearance measurements. The radioiodines 123I, 124I, 125I and 131I were accommodated as tracers and therapeutic agents by incorporating their physical half lives and by precalculating photon-absorbed fractions for these radionuclides for several thousand patient geometries using Monte Carlo simulations. RESULTS: A(max) and D(lesion) have been calculated using the traditional and new method for a group of patients, and errors associated with each of the above assumptions were examined. Assuming that the initial blood activity is distributed instantaneously in 5 L was found to introduce an error in A(max) of up to 30%, whereas assuming physical decay beyond the last data point introduced an error of up to 50%. CONCLUSION: Individualized fitting of clearance data is a practical method to accurately account for inter-patient kinetics variations. The substitution of standard kinetics beyond measured data might lead to substantial errors in estimating A(max) and D(lesion). In addition, gamma camera images, rather than neck probe readings, should be used to determine lesion uptakes for thyroid cancer patients.

Humans↗