Community-acquired lobar pneumonia in an HIV-infected patient.
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AIDS-Related Opportunistic Infections↗
Biomedical subjects
P Burden
Publications and source records attributed to P Burden.
Factors affecting results obtained with European Community tests for pasteurized milk sampled at the heat treatment establishment.
A total of 3000 samples of pasteurized milk taken at the heat treatment establishment over a 1-year period were examined for the presence of phosphatase and by a plate count at 30 degrees C, a coliform count at 30 degrees C, and a plate count at 21 degrees C after pre-incubation of the sample for 5 days at 6 degrees C, performed as prescribed in EC Directive 85/397/EEC. Samples were also examined for presence of Listeria species. Of 2690 samples (1713 from small dairies and 977 from large commercial premises) received at 4 degrees C or less, 96 (3.6%) has a plate count at 30 degrees C exceeding 30,000 organisms per ml, 608 (22.6%) contained 1 or more coliforms per ml, and in 1327 (49.3%) the pre-incubated count exceeded 100,000 organisms per ml. Thirty two samples from 23 dairies contained phosphatase. Listeria species were detected in 25 samples; only three of these strains were identified as Listeria monocytogenes. Results were analysed to determine relationships between factors which might affect test results. Samples from small dairies showed significantly higher coliform counts and pre-incubated plate counts than did those from large commercial premises. They were also more likely to contain phosphatase or Listeria species. Samples were significantly more likely to contain coliforms when taken in the July-September quarter or if received in glass containers.
Animals↗
Lemierre syndrome--a forgotten complication of acute tonsillitis.
Lemierre syndrome, also known as postanginal sepsis, is an illness characterized by the development of a fusobacterial septicaemia with multiple metastatic foci following an attack of acute tonsillitis. It typically affects previously healthy adolescents and young adults who, following an attack of sore throat, become acutely ill with hyperpyrexia, rigors and multiple metastatic abscesses. The clinical picture tends to vary widely because of the possible involvement of a number of body systems and organs in the disease process. This serious complication of oropharyngeal sepsis had a mortality rate in excess of 90 per cent in the pre-antibiotic era. Although now rarely seen and often forgotten, it remains a potentially life-threatening condition. We present four cases of post-tonsillitis fusobacterial septicaemia to illustrate the variability of the clinical presentation and stormy clinical course frequently associated with this rare syndrome.
Acute Disease↗
Gram negative septicaemia diagnosed on peripheral blood smear appearances.
Buffy coat smears from febrile patients may contain visible bacteria and therefore detect bacteraemia before conventional blood cultures become positive. However, it is unusual to see micro-organisms in an otherwise untreated peripheral blood smear. The case of a febrile neutropenic patient is reported. A Wright's stained peripheral blood smear contained bacterial elements, thus making earlier diagnosis of septicaemia and identification of the causative bacterium possible.
Bacteremia↗
Fusobacterium necrophorum and Lemierre's syndrome.
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Animals↗
The occurrence of Listeria species in milk and dairy products: a national survey in England and Wales.
A total of 4172 samples of milk, cheese and other dairy products were examined over a 1-year period for the presence of Listeria species. Strains of Listeria were found most frequently in soft, ripened cows milk cheese; 63 out of 769 (8.2%) samples contained Listeria monocytogenes, 25 samples contained species other than L. monocytogenes, and 18 samples contained both L. monocytogenes and other Listeria spp. Eleven samples of pasteurized cows milk (1.1%) from four dairies contained L. monocytogenes, and other Listeria spp. were isolated from a further five samples. Goats and ewes milk and their products, yogurt, cream and ice cream also occasionally contained Listeria spp. Levels of Listeria were usually low, but 20 samples of cheese contained more than 1000 cfu/g. Most strains of L. monocytogenes belonged to serotype 1/2 (58%) or serotype 4b (33%).
Animals↗
Structures of colchicine analogues. I. Allocolchicine.
Methyl 5-acetylamino-6,7-dihydro-9,10,11-trimethoxy-5H-dibenzo[a,c] cycloheptene-3-carboxylate, C22H25NO6, Mr = 399.4, monoclinic, P2(1), a = 7.968 (1), b = 9.482 (1), c = 15.063 (2) A, beta = 112.95 (1) degrees, V = 1047.9 (2) A3, Z = 2, Dm(flotation) = 1.27 (1), Dx = 1.266 Mg m 3, lambda(Cu K alpha) = 1.5418 A, mu = 0.68 mm 1, F(000) = 424, T = 288 (1) K. Final R = 0.050 for 1765 observed data. The seven-membered ring has the expected boat conformation, and the angle between the normals to the phenyl rings is 48.7 (4) degrees. The relative orientations of the three adjacent methoxy groups and the acetamido substituent are similar to those observed in crystals of colchicine. Intermolecular hydrogen bonds between the N and O atoms of the acetamido groups link the molecules into infinite spirals along the b axis.
Chemical Phenomena↗