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Biomedical subjects

P C Egbe

Publications and source records attributed to P C Egbe.

8 recordsLinked to original sources
PubMed1990

Anticonflict effects of low doses of chloroquine.

The effects of low doses (0.125-1 mg/kg) of chloroquine were investigated in a modified Vogel's conflict paradigm and in the light-dark transition box. In the Vogel's conflict paradigm, the compound was found to exert a marked dose-dependent increase in the number of shocks accepted by rats in the conflict situation, thus indicating an anxiolytic-like action. In the light-dark transition box, chloroquine increased the number of transitions between the two compartments and the time spent in the lighted area by mice. Thus chloroquine exhibited anticonflict properties in two animal models of anxiety. It is therefore concluded that chloroquine might possess antianxiety-like properties in low doses.

Animals↗
PubMed1989

Locomotor effects of amperozide. Antagonism of amphetamine-induced locomotor stimulation.

Amperozide given subcutaneously (0.25 mg/kg) depressed amphetamine-induced locomotor activity by 40%. In the absence of amphetamine (1.5 mg/kg), this dose of amperozide had no effect on locomotor activity during the 60 min test period. Amperozide (0.1-1 mg/kg) dose-dependently decreased the locomotor activity of mice as measured in motron boxes. Only doses of amperozide greater than 0.25 mg/kg resulted in statistically significant (p less than 0.05) decreases in motor activity. Pretreatment of mice with flumazenil (10 mg/kg p.o., 30 min) or bicuculline (2 mg/kg i.p., 10 min) had no effect on amperozide (1 mg/kg)-induced hypomotility. These doses of the drugs had no effect per se. These results suggest that dopaminergic mechanisms might be involved in the amperozide-induced hypomotility.

Animals↗
PubMed1982

The involvement of the catecholaminergic system in physostigmine-induced hyperactivity in rats.

Physostigmine-induced hyperactivity in rats was attenuated by reserpine 5 mg/kg) and haloperidol (0.025 mg/kg). Pretreatment with (bis-4-methyl-1-homopiperizinyl-his-carbonyl) disulphide (FLA-63) (2.5 mg/kg) resulted in physostigmine producing a biphasic effect on rats' locomotion while pretreatment with p-chloro-phenylalanine (pCPA) (300 mg/kg) did not significantly affect physostigmine-induced hyperactivity. The relevance of the catecholaminergic system in mediating physostigmine-induced hyperactivity is discussed.

Animals↗
PubMed1977

Differential attenuation by atropine and d-amphetamine on hyperactivity: possible clinical implications.

Intraperitoneal administration of physostigmine (0.025 to 0.18 mg/kg) to rats resulted in significant increases in motor activity as measured with jiggle platforms. Doses of physostigmine 0.2 mg/kg or more decreased motor activity. The physostigmine-induced hyperactivity was attenuated by atropine (5 mg/kg) given before or after physostigmine (0.05 mg/kg). On the contrary, d-amphetamine (2 mg/kg), given before or after, significantly potentiated the physostigmine-induced increase in motor activity. The relevance of the cholinergic system in mediating hyperactive behaviour in children is discussed.

Animals↗