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P C Ligtenberg

Publications and source records attributed to P C Ligtenberg.

9 recordsLinked to original sources
PubMed1999

No effect of long-term physical activity on the glycemic control in type 1 diabetes patients: a cross-sectional study.

BACKGROUND: The main purpose of the present study was to assess the relation between long-term physical activity and glycemic control in patients with type 1 diabetes mellitus. METHODS: Medical data and blood samples for the determination of glycosylated hemoglobin (glyHb) were collected in 221 consecutive type 1 diabetes patients between 18 and 45 years of age without late complications. A self-report questionnaire was used to determine the degree of physical activity. Correlation coefficients and analysis of variance were used for statistical analyses. RESULTS: No correlation was observed between the different levels of physical activity and glycemic control. Females showed a significantly higher total physical activity index than males (p = 0.004), mostly due to the leisure time activity index. More active patients used a lower amount of insulin (r = -0.20, p = 0.002) than less active patients. CONCLUSIONS: Glycemic control was not found to be associated with long-term physical activity in type 1 diabetes patients. Physical activity did not negatively affect long-term glycemic control.

Adolescent↗
PubMed1999

Serum leptin levels are not influenced by physical training in type 2 diabetes mellitus patients.

AIM: To investigate the effect of physical training on leptin levels in elderly, obese patients with type 2 diabetes mellitus. METHODS: Twenty men and 38 women with type 2 diabetes mellitus with a body mass index (BMI) of > 25 kg/m2 participated in a prospective randomized study. Patients were either on oral glucose lowering drugs (n = 39) or insulin therapy (n = 19). Physical training consisted of a guided, standardized, 6-week training programme performed in the hospital on a cyclo ergometer followed by a 6-week period of guided training at home and ended in a 12-week period of training at home without supervision. Clinical data and laboratory samples including fasting insulin and leptin levels and maximal aerobic capacity were assessed at the start of the study and at 6 and 26 weeks thereafter. RESULTS: Physical training resulted in significantly positive changes in maximal aerobic capacity (VO2max) and maximum work load. No effects of physical training on serum leptin levels and insulin concentrations were detected. Leptin levels were strongly correlated with body mass index (r = 0.63), body fat content (r = 0.61), and fasting insulin concentrations (r = 0.38). Women had threefold higher leptin levels than men. No differences in leptin levels between patients on insulin therapy and patients on oral glucose lowering drugs were found. CONCLUSIONS: No effect of physical training on leptin levels was detectable in elderly, obese type 2 diabetes mellitus patients.

Aged↗
PubMed1997

Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients.

1. The specific role of physical activity in the treatment of type 2 diabetes is still subject to discussion. A randomized prospective study was performed, investigating both the influence of physical training on metabolic control and the feasibility of physical training in the elderly. 2. A total of 58 patients (mean age: 62 +/- 5 years; range: 55-75 years) with type 2 diabetes were randomized to either a physical training or a control programme. The training programme consisted of three sessions a week, aiming at 60-80% of the maximal oxygen uptake (VO2max). The 12 week supervised period was followed by a 14 week non-supervised one. The control group followed an educational programme. VO2max was assessed during exercise on a cycle ergometer. Glycosylated haemoglobin (HbA1c) was used as a measure for glucose control, and an insulin tolerance test was performed to test insulin sensitivity. Multivariate analysis of variance, with repeated measures design, was used to test differences between groups. 3. Fifty-one patients completed the study. VO2max was higher in the training group than in the control group both after 6 weeks (P < or = 0.01 between groups) and after 26 weeks [training group: 1796 +/- 419 ml/min (prestudy), 1880 +/- 458 ml/min (6 weeks), 1786 +/- 591 ml/min (26 weeks); control group: 1859 +/- 455 ml/min (prestudy), 1742 +/- 467 ml/min (6 weeks), 1629 +/- 504 ml/min (26 weeks)]. Blood glucose control and insulin sensitivity did not change during the study. Levels of total triacylglycerols, very-low-density lipoprotein-triacylglycerols and apolipoprotein B were significantly lower after 6 weeks (P < or = 0.01, P < or = 0.05, P < or = 0.05 between groups respectively), and so was the level of total cholesterol after 12 weeks of training (P < or = 0.05 between groups). 4. Physical training in obese type 2 diabetic patients over 55 years of age does not change glycaemic control or insulin sensitivity in the short-term. Regular physical activity may lower triacylglycerol and cholesterol levels in this group of patients. 5. Finally, physical training in motivated elderly type 2 diabetic patients without major cardiovascular or musculoskeletal disorders is feasible, but only under supervision.

Aged↗
PubMed1994

Q-fever in a patient with a ventriculo-peritoneal drain. Case report and short review of the literature.

Although Q-fever is still a relatively rare disease in the Netherlands, its incidence seems to be increasing. In this article we describe the case-history of a 65-year-old woman with a Pudenz-drain, who acquired Q-fever pneumonia while manuring her garden. The course of the disease was deviant, which most likely was caused by colonization of the ventriculo-peritoneal drain with Coxiella burnetii. Q-fever usually presents as a self-limiting illness. In the case of chronic Q-fever, complications such as endocarditis, hepatitis or meningo-encephalitis can be fatal and require long-term treatment. Patients with artificial drains or valves carry a greater risk of developing such complications. Therefore, especially in patients at risk, Q-fever should be included in the differential diagnosis when dealing with a patient with unexplained fever.

Aged↗
PubMed1992

[Villous adenoma of Vater's papilla; a therapeutic dilemma].

After a cholecystectomy in 1980, local excision of a villous adenoma of the ampulla of Vater was performed in 1983 in a 69-year-old female; this had to be repeated in 1990 because of recurrence. In case of a tumour of this kind, pancreaticoduodenectomy should be considered because of the relatively high risk of recurrence or malignant degeneration. After a radical local excision regular duodenal endoscopy and if possible endoscopic ultrasonography should be performed.

Adenocarcinoma↗
PubMed1991

[Zidovudine treatment and need of blood transfusion in patients with AIDS].

The treatment of AIDS patients with zidovudine extends their survival time. However, hematological side effects frequently require a reduction of the dosage and the administration of blood transfusions. We reviewed the history of zidovudine treatment and blood transfusions for 27 patients with AIDS treated in the University Hospital Utrecht between July 1st, 1987 and July 1st, 1990. The initial dosage of zidovudine was 1000-1200 mg daily orally. Two months after the initiation of the therapy, 48% of the patients required a reduction of the zidovudine dosage. This percentage had increased to 85% after 12 months since the start of the therapy. During this period, 26% of the patients received blood transfusions. The zidovudine dosage was on the average of 480 mg per day after reduction. One year after the start of the therapy, 81% of the patients were still alive, and after 1 1/2 years this percentage was 68. In our study the proportion of patients undergoing a reduction of the zidovudine dosage was high in comparison with data reported in the literature. However, the need for blood transfusions was clearly lower. The survival percentages after 1 and 1 1/2 years were about the same as reported in other studies. Therefore, we conclude that an early reduction of the zidovudine dosage and resulting low total dosage were effective and resulted in a decreased need for blood transfusions.

Acquired Immunodeficiency Syndrome↗
PubMed1991

C-reactive protein in the diagnosis and management of infections in granulocytopenic and non-granulocytopenic patients.

The serum levels of C-reactive protein (CRP) were assayed in 64 non-granulocytopenic and 35 granulocytopenic patients with or without fever and infection. Most patients showed a direct CRP response within 24 hours after onset of fever (95% of non-granulocytopenic patients, 100% of granulocytopenic patients). The mean peak level of CRP in febrile patients with septicemia was 207 mg/l (median 214 mg/l) in non-granulocytopenic patients and 173 mg/l (median 168 mg/l) in granulocytopenic patients, and differed significantly (p less than 0.001) from that in febrile patients without positive blood cultures. A significant difference between patients with major and minor infections was also found (p less than 0.01). No significant difference in the CRP level was found between patients with microbiologically and clinically documented infections (p greater than 0.05), nor did the serum CRP levels differ between patients with infections due to gram-positive and gram-negative organisms. The most favorable cut-off limit for detection of an inflammatory process in this study was 25 mg/l. There was no quantitative difference between CRP levels measured by a latex-agglutination method and the nephelometry assay.

Adolescent↗