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Biomedical subjects

P C Reade

Publications and source records attributed to P C Reade.

At least 73 records · Page 4Linked to original sources
PubMed1989

Angiotensin-converting enzyme inhibitors implicated in oral mucosal lichenoid reactions.

The use of angiotensin-converting enzyme inhibitors (captopril and enalapril) to control hypertension has increased in recent years. Despite extensive reports of hematologic, gastrointestinal, and cutaneous side effects, no specific incidence of oral mucosal lichenoid reactions caused by these drugs have been reported. It is the purpose of this article to present two case reports, bringing the attention of clinicians to oral mucosal lichenoid drug reactions in which these drugs may be implicated.

Aged↗
PubMed1989

Healing following coronoidotomy in rats.

Coronoidotomies were performed in laboratory rats in order to describe the histological features of the healing process. In all longer-term specimens, the coronoid process reattached to the mandibular ramus by means of intracartilagenous bone formation within 4-6 weeks of surgery. This finding may give some indication of events occurring in humans following coronoidotomy.

Animals↗
PubMed1989

A quantitative assessment of Langerhans cells in oral mucosal lichen planus and leukoplakia.

Quantitative analysis of Langerhans cells stained with OKT6 in the epithelium of 42 patients with oral mucosal lichen planus and 14 patients with oral mucosal leukoplakia showed significantly greater numbers of Langerhans cells in lichen planus. This may reflect the role of Langerhans cells in the pathogenesis of this condition and their identification could help in distinguishing lichen planus from leukoplakia.

Cell Count↗
PubMed1989

On the pattern of ameloblast migration.

The kinetics of ameloblast cells in continuously growing guinea pig molars were studied using autoradiography. The results showed that there was no direct relationship between ameloblast migration rate and ameloblast production rate, which indicated that ameloblasts actively migrated coronally. It was found that ameloblast migration rate was maximal at the root apex, and then reduced to a minimum value as the ameloblasts left their proliferative compartment and migrated coronally. A multiple regression model was found to be the most suitable one to represent the ameloblast migration pattern.

Ameloblasts↗
PubMed1989

A dental survey of Tibetan children in Dharamsala.

Since their exodus in 1959 about 100,000 Tibetans have settled in disparate communities in northern India and Nepal. This study describes the dental health of 243 Tibetan children in Dharamsala, in the State of Himachal Pradesh, India. Only 20% of 6-yr-olds were caries-free in the primary dentition while 96.9, 53.3, and 22.4% of 6, 12, and 15-yr-olds were caries-free in the permanent dentition respectively. The DMFT of 12-yr-old children was 1.1, while 15-yr-old children had a DMFT of 3.1. While plaque and calculus were present in many sextants, there was little intense gingivitis and signs of advanced periodontal diseases were rarely present. Almost no dental care had been received. Appropriate dental health promotion activities are discussed.

Adolescent↗
PubMed1988

Early post-operative endodontic therapy limits inflammatory root resorption of autotransplanted maxillary canine teeth.

This study has provided information concerning the limitation of inflammatory root resorption of autotransplanted maxillary canine teeth. It has been shown that early post-operative endodontic therapy significantly decreases the occurrence of inflammatory root resorption (P less than 0.001) but does not change the prevalence of replacement root resorption. It is argued that by limiting inflammatory resorption the prognosis for autotransplanted teeth is considerably improved.

Adolescent↗
PubMed1988

Hemifacial atrophy and temporomandibular joint pain-dysfunction syndrome.

A case is described of a patient with progressive HA who presented because of left TMJ pain, jaw locking and ipsilateral masticatory muscle spasm. Several reports exist in the literature of masticatory muscle spasm associated with HA. A diagnosis of TMJPDS was made and an occlusal splint was provided which produced resolution of the TMJ pain and jaw locking and significantly reduced the masticatory muscle spasms.

Adult↗
PubMed1988

Direct immunofluorescence in the diagnosis of oral mucosal diseases.

Direct immunofluorescence is an important technique in establishing the diagnosis of a variety of diseases. It has become a useful adjunct to the diagnosis of oral mucosal diseases, yet many practitioners find the field confusing. This paper summarises the published findings and presents a table for ready reference for clinicians.

Aged↗
PubMed1988

Histomorphometric analysis of epithelial changes in chemically induced oral mucosal carcinogenesis in rats.

Quantitative analysis of rat palatal mucosa after the carcinogen 4- nitroquinoline-1-oxide had been applied to the epithelium for varying periods of time showed that there was a significant increase in epithelial thickness, due largely to an increase in thickness of the basal compartment. This alteration was measurable before epithelial dysplasia could be recognised.

4-Nitroquinoline-1-oxide↗
PubMed1988

Factors associated with the development of neoplasia.

A number of factors have been associated with the development of the phenotypic expression of neoplastic disease. The following article reviews the evidence implicating these factors in carcinogenesis and considers them under the groupings of familial or genetic factors, dietary factors, hormonal factors, age and gender.

Age Factors↗
PubMed1988

Differences between preneoplastic cells, neoplastic cells and their normal counterparts.

A number of changes occur in preneoplastic and neoplastic cells as they progress towards a greater degree of malignancy. These alterations include genetic changes, epigenetic changes, surface alterations and alterations in intercellular interactions. In some instances, these changes are contributing factors to the degree of pathology noted, whilst other are resultant. In many situations, the relationship between these changes and the progression towards neoplasia is not understood. Nevertheless, it seems probable that these changes are ultimately involved in driving cells further along the path to neoplastic transformation. It is the purpose of this review to consider the changes which occur as cells progress from normality to being neoplastic, with particular reference to the cells of the oral mucosa, and the use to which detectable changes can be used as prognostic indicators.

Cell Transformation, Neoplastic↗