Biomedical subjects
Publications and source records attributed to P C Reade.
Seven cases of dentinal dysplasia Type I and a case of dentinal dysplasia Type II have been presented, and the literature concerning these rare disorders has been reviewed. Attention has been drawn to the important clinical and histological features of these dental abnormalities.
A case of unilateral cherubism is presented in which only one side of the mandible was affected. The associated diagnostic features are discussed.
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Pain or discomfort in the orofacial region usually has an organic and easily detectable cause. When an organic cause is absent or its magnitude is less than expected after the degree of concern expressed by the patient, a psychiatric factor must be considered. In such cases psychiatric treatment should be arranged to complement any necessary organic therapy.
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A brief review of the published results of autotransplanting maxillary canine teeth has been presented together with the results of a prospective study in which 141 maxillary canine teeth were surgically repositioned in 113 patients, but not root-treated unless resorption occurred. Attention was given to assessing factors (age, sex, tooth positions, surgical difficulty, time out of mouth, acute infection, periodontal disease, caries, occlusion, formation of lamina dura) associated with root resorption of the transplanted teeth but no particular factor of significance emerged. It has been speculated that early post-operative root canal treatment and/or a two-stage technique might reduce the incidence of root resorption of autotransplanted teeth.
From a continuing study of 108 cases of oral mucosal lichen planus, including so-called drug-induced lichenoid reactions, the response of patients to topical therapy and to drugs implicated in inducing the lichenoid reactions was used to construct a hypothetical model regarding the pathogenesis of the condition. The results were interpreted to indicate that lichen planus is a predetermined condition or diathesis, perhaps genetically based, rather than a simple cause-and-effect disorder.
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Whilst the content of epidermal growth factor in the submandibular salivary glands has been considered to be controlled primarily by the hormonal secretions of the testes, our previous studies indicated that the adrenal glands also affect the cellular content of epidermal growth factor in these glands. In the present study, the influence of the thyroid gland was investigated. One hundred and ten males Swiss White mice were subjected to orchidectomy and/or bilateral adrenalectomy, or thyroidectomy, and their submandibular salivary glands examined at 90 days of age. Some of these received specific hormone replacement prior to examination of the glands. The presence of epidermal growth factor was detected by indirect immunofluorescence, and adjacent sections of tissue were stained with alcian blue and acid fuchsin to demonstrate the convoluted granular tubules, which are the site of storage of the factor in the glands. In the glands of normal males, these tubules were prominent and showed strong factor-positive immunofluorescence. Administration of thyroxine reversed orchidectomy-induced atrophy of the tubules, and restored factor content, but did not restore normal tubular morphology or factor content in orchidectomised-adrenalectomised animals. In these latter animals, combined administration of thyroxine and cortisone resulted in a return to normal structure and growth factor content in the cells of the convoluted granular tubules. The glands from thyroidectomised males had atrophied tubules, which did not contain demonstrable epidermal growth factor. These effects were reversed by the administration of thyroxine, testosterone, thyroxine and testosterone, or thyroxine and cortisone. The results show that the content of epidermal growth factor-positive cells in the convoluted granular tubules of the submandibular salivary glands of male mice is under the control of the thyroid as well as the testes and adrenal glands.
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Partially-developed teeth with remnants of their periodontal ligaments isografted to the tibial shaft medulla and renal subcapsular site were capable of progressive regeneration characterized by renewed tubular dentine formation. Bone formation occurred in relation to grafts at the renal site as well as the tibial shaft; evidence of periodontal fibre reorganization was observed in grafts at both sites. Despite post-transplantation dentine and cementum formation, continued development of roots of normal morphology did not occur, perhaps due to disappearance of epithelial root sheath.
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There seems to be no relationship between time of day and SlgA concentration in pooled unstimulated saliva. Such concentrations are more accurately expressed as a range of normal. A selected group of tobacco smokers showed a decrease in SlgA concentrations when compared with a matched control group, and a group of patients with minor aphthous ulcerations showed no deviation from the control range. The significance of the decrease in SlgA concentrations in chronic tobacco smokers is discussed in the light of this being due to an immunosuppressive effect of the combustion products of tobacco and the possibility of the incidence of intraoral neoplastic disease being increased in tobacco smokers by this effect.