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Biomedical subjects

P C Shah

Publications and source records attributed to P C Shah.

13 recordsLinked to original sources
PubMed1979

Plasmacytoma of the stomach.

A case of gastric plasmacytoma is presented. A detailed study including a selective angiogram described this unusual gastric neoplasm. Pathological examination by both light and electron microscopy confirmed the diagnosis of primary gastric plasmacytoma. The diagnosis and treatment of primary gastric plasmacytoma is discussed and pertinent literature is reviewed.

Aged↗
PubMed1978

Cyclophosphamide induced nail pigmentation.

Cyclophosphamide therapy may occasionally cuase black pigmentation of the nails. We report five cases with this side effect and review the data on eleven cases in the literature. These changes start in the proximal nail beds and progress distally; on withdrawal of cyclophosphamide, clearing of the nail pigmentation proceeds in a similar fashion. The development of the nail pigmentation does not bear any relation to the primary condition for which cyclophosphamide was prescribed. The dose of the drug before the onset of pigmentation ranged from 1.2 to 12.3 g; the duration of treatment ranged from 10 days to 26 weeks. The mechanism of the nail pigmentation is unknown.

Adolescent↗
PubMed1978

Transient pseudoleukocytosis caused by cryocrystalglobulinemia.

A patient with Sjögren's syndrome and cryoglobulinemia was found to have pseudoleukocytosis when a leukocyte count was performed on an electronic particle counter. This apparent increase in the leukocyte count was found to be caused by spontaneous crystallization of the cryoglobulin. Further studies showed that this phenomenon was transient. Disappearance of the spontaneous crystal formation without a change in the level of cryoglobulin suggests the possibility of an interaction between the cryoglobulin and a plasma component. Factors affecting spontaneous crystallization of cryoglobulins and the laboratory as well as the clinical implications of pseudoleukocytosis are discussed.

Cold Temperature↗
PubMed1977

Acute renal failure after low-dose irradiation. A complication of chronic lymphocytic leukemia.

A middle-aged woman received low-dose irradiation for treatment of chronic lymphocytic leukemia: 1,000 rads to the spleen in four sessions over four days and 400 rads to each abdominal quadrant in eight sessions over eight days. Three days after the last irradiation session, acute hyperuricemic renal failure developed and conservative treatment was begun, with use of hydration, forced diuresis, alkalization, and short-term peritoneal dialysis. Uric acid levels were carefully monitored. Renal function promptly returned to normal.

Acute Kidney Injury↗
PubMed1977

Hemophiliac with hemolytic anemia resulting from factor VIII concentrate.

Bilateral herniorrhaphy was successfully performed on a group AB hemophiliac with cirrhosis of the liver. Adequate hemostasis was maintained with infusions of commercial factor VIII concentrates and fresh frozen plasma. An anti-A antibody mediated hemolytic reaction occurred in the postoperative period. Hemolysis subsided after the cessation of commercial factor VIII infusions. The risk of such hemolytic reactions could be eliminated through the use of group-specific cryoprecipitated factor VIII.

ABO Blood-Group System↗
PubMed1977

Folate deficiency during intravenous hyperalimentation.

Two alcoholic patients were supported with hyperalimentation therapy during the management of complicated surgical problems. Folate deficiency was documented after ten and two weeks of intravenous feeding. One patient developed severe pancytopenia. Folic acid treatment resulted in hematologic recovery in both cases. Early development of folate deficiency in these patients seems to be related to multiple factors, viz., poor folate stores related to chronic alcoholism, poor dietary intake before and during the hospitalization, infection, prolonged gastric suction, and lack of folate in the intravenous hyperalimentation fluids. Rationale for the supplementation of folates in such patients is discussed.

Adult↗
PubMed1976

Cyclophosphamide therapy and interstitial pulmonary fibrosis.

Intersitial pneumonia and pulmonary fibrosis developed in a 72-year-old man during therapy with cyclophosphamide, vincristine, and prednisone. After extensive investigations, including an open lung biopsy, cyclophosphamide appeared to be the cause of the pulmonary disease. Complete disappearance of tachypnea and the pulmonary infiltrates occurred after the discontinuation of cyclophosphamide and the institution of prednisone therapy. We concluded that the diffuse pulmonary disease in this patient was a result of cyclophosphamide therapy. The clinical and pathologic findings in this case and a review of the literature of cyclophosphamide pulmonary toxicity are reported.

Adult↗