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Biomedical subjects

P C Sharpe

Publications and source records attributed to P C Sharpe.

6 recordsLinked to original sources
PubMed1978

Comparative study of carbuterol and salbutamol from metered aerosols in bronchial asthma.

In a double-blind crossover trial carbuterol and salbutamol were administered by aerosol for 7 days each to 20 patients with reversible obstructive airways disease. In addition to assessment of subjective response, objective measurements were made of response of the respiratory system (FEV1, FVC, MMEFR) and cardiovascular system (pulse rate, blood pressure, ECG) to each drug. Both carbuterol and salbutamol were found to be effective, well-tolerated bronchodilators when given over a 7 day period; there was no significant difference between the drugs in any of the parameters studied. Carbuterol is a safe and effective alternative to salbutamol.

Aerosols↗
PubMed1975

Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Cimetidine, a new H2-receptor antagonist, was safely administered to eighteen healthy man by the intravenous, intraduodenal or oral route. 2 When gastric secretion was maximally stimulated by either histamine or pentagastrin, the simultaneous administration of cimetidine produced marked inhibition of both acid and pepsin secretion. 3 Cimetidine was well absorbed by mouth and had a blood half-life of 2 hours. 4 Cimetidine was rapidly excreted via the kidneys and about 70% of the excreted material was unchanged drug. 5 Clinical evaluation of cimetidine in patients with peptic ulceration is recommended.

Administration, Oral↗