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Biomedical subjects

P C Trexler

Publications and source records attributed to P C Trexler.

At least 19 recordsLinked to original sources
PubMed1983

Use of flexible plastic film isolators in performing potentially hazardous necropsies.

A number of necropsies were performed with the body completely isolated in a flexible film isolator in order to determine the practicability of such a method in protecting the post mortem room staff from the risk of infection from the corpse. It is considered that necropsies can be carried out using such an isolator without hindrance to either manual skill or vision and that a high degree of safety is achieved. The isolator may also be used to carry out necropsies on decomposed bodies.

Autopsy↗
PubMed1979

Transfer isolator to protect personnel from exposure to peracetic acid.

A transfer isolator is described which confines peracetic acid fumes used in the gnotobiotic operation of isolators. The use of this isolator protects both personnel and animals from contact with peracetic acid, provides additional isolator space and reduces wear on the gloves and sleeves of the main isolator.

Acetates↗
PubMed1977

Negative-pressure plastic isolator for patients with dangerous infections.

A negative-pressure plastic isolator is effective for dealing with patients suffering from dangerous infections. So far it has been used to treat seven patients suspected of having infections due to Lassa, Marburg, or Ebola viruses. One patient spent 32 days in the isolator. The isolator was proved comfortable and acceptable to patients, and it gives the nursing and medical attendants a high degree of protection. All routine nursing and medical procedures can be carried out with minimal interference by the physical barrier, though it is not practicable to undertake artificial respiration or haemodialysis.

Atmospheric Pressure↗
PubMed1976

A source isolator for infected patients.

A plastic, mechanically ventilated source isolator with filters in the air effluent was designed to enable infected patients to be nursed and treated in a general ward or to be transported without risk to staff or other contacts. Two models of isolator were developed. Their potential value was tested by the challenge of heavy dispersal, inside the isolator, of bacteria (a) from patients with burns, during the change of dressings, (b) from contaminated bedding during simulated bed-making, and (c) from the dispersal of a suspension of Bacillus subtilis var. globigii. Sampling of air by slit samplers outside the isolator and, in comparable control patients, from the air of the room in which dressings were changed, showed consistently lower counts of bacteria and of Staph. aureus during dressings when the isolator was used; on removal of the isolator canopy there was, in some experiments, a considerable increase in airborne bacteria, due to residual bacteria in the isolator of to the re-dispersal of bacteria which settled on the patient and his bedding during the dressing. Simultaneous sampling with slit samplers inside and outside the isolator during and after bed-making or dispersal of B. subtilis var. globigii showed an almost complete protection of the air outside the isolator against contamination by bacteria released inside the isolator.

Adolescent↗
PubMed1975

Plastic isolators for treatment of acute leukaemia patients under "germ-free" conditions.

A gnotobiotic isolation system based on those developed in veterinary research has been constructed for hospital use. Fifteen patients with leukaemia and neutropenia spent a total of 110 weeks in plastic isolators, and none acquired any infection. Endogenous flora was effectively suppressed by topical antiseptics and gastrointestinal decontamination effected with nonabsorbable antibiotics. The isolator system was acceptable to patients and staff and much cheaper than the use of sterile rooms. Other advantages of the system are portability, easy storage, and use on ordinary open wards without prejudice to the microbiological protection afforded. It is as yet uncertain whether protective environments of this type will substantially improve the outcome of treatment for the acute leukaemias.

Acute Disease↗
PubMed1975

The gnotobiotic foal in the study of infectious diseases.

A method of rearing germ-free gnotobiotic foals is described. To date, four foals have been infected with rhinopneumonitis and the only clinical signs of infection have been a transient fever and leukopaenia; no detailed results are, as yet, available.

Animals↗
PubMed1975

Microbial isolators for use in the hospital.

Isolators made of flexible transparant plastic film maintain a physical separation between clean and dirty areas without interfering with the use of the isolated space. The reliability with which isolators maintain sterility has been demonstrated by the germ-free rearing of the common laboratory and domestic animals. Isolators are used routinely in orthopaedic surgery and for protecting patients who have severe congenital immune deficiency disease or are made infection-prone because of therapy.

Animals↗
PubMed1974

The surgical isolator.

A plastic film isolator has been developed which is intermediate between a half-suit and an arm isolator. Used for orthopaedic surgery in an aseptic environment few operating difficulties have been found, and an extended trial of its use should be carried out to assess its effect on the incidence of postoperative wound infection.

Air Microbiology↗