PubMed Health⌕ Search

Biomedical subjects

P Campognone

Publications and source records attributed to P Campognone.

7 recordsLinked to original sources
PubMed1996

Lack of requirement for prolonged incubation of Septi-Chek blood culture bottles in patients with bacteremia due to fastidious bacteria.

A questionnaire survey for which there were 538 respondents from American clinical microbiology laboratories was used to assess the need for prolonged incubation of Septi-Chek blood culture bottles for the recovery of HACEK bacilli, Brucella species, Francisella tularensis, and nutritionally deficient streptococci from blood. Among a total of 219 reported isolates of these bacteria, in only 6 cases (2.7%) was incubation longer than 7 days required. Only 2 of 136 patients (1.5%) were noted to be bacteremic exclusively following incubation of Septi-Chek blood culture bottles for periods of greater than 7 days. It appeared from the results of this study, that incubation of Septi-Chek blood culture bottles for 7 days is usually sufficient in patients suspected of having bacteremia due to fastidious bacteria.

Bacteremia↗
PubMed1986

Neonatal sepsis due to nontypable Haemophilus influenzae.

From August 1980 through July 1984, 19 neonates had sepsis due to Haemophilus influenzae. Onset of disease occurred within 48 hours after birth of all the neonates. One neonate was born at term and 18 were born prematurely, including seven neonates born before 28 weeks' gestation. Eight neonates and one fetus died, six of them within 24 hours of birth. Acute chorioamnionitis was present in the placentas. Those neonates with the most severe placental inflammation survived while all of those who died had moderate or only mild chorioamnionitis. Acute villitis was noted in the placentas of three neonates who died. Respiratory distress syndrome (in 15 neonates) and pneumonia (in 15 neonates) were noted in 18 liveborn patients. Nine mothers had fever, six of them with genitourinary infections and one with septicemia due to H influenzae. All isolates of H influenzae were submitted for serologic typing and none were typable. In 14 cases, isolates were biotyped yielding eight with biotype II, four with biotype III, and one each with biotypes IV and V. Neonatal sepsis due to nontypable H influenzae is now nearly as common as sepsis due to group B Streptococcus. Both organisms produce diseases with many features in common, especially fulminant courses with respiratory distress and pneumonia, and often have a fatal outcome.

Anti-Bacterial Agents↗
PubMed1986

Increased detection of prolylaminopeptidase in Neisseria meningitidis by Identicult-Neisseria.

Identicult-Neisseria (Scott Laboratories, Inc., Fiskeville, R.I.), a rapid enzymatic method with chromogenic substrates, was tested in our laboratories for the identification of Neisseria gonorrhoea, Neisseria meningitidis, and Neisseria lactamica. The test correlated very highly in its identification of pathogenic Neisseria spp. with modified New York City fermentation medium. Identicult-Neisseria appeared to be more sensitive in its detection of prolylaminopeptidase activity in N. meningitidis than most of the currently available systems.

Aminopeptidases↗
PubMed1986

Perinatal group B streptococcal infection in midgestation.

In a series of 32 fetuses and neonates studied at autopsy at Women and Infants Hospital, group B streptococcus (GBS) was isolated from the right atrial blood or from the lung. Eleven or 34% (5 stillborn fetuses and 6 liveborn infants) were delivered in midgestation, between 18 and 28 weeks, and all weighed less than 1000 g. Maternal clinical features in GBS infection during midgestation included vaginal hemorrhage in 4 and premature rupture of membranes in 8. The high rate of fetal death associated with this infection in midgestation (45%) bears emphasizing. Reproductive loss among mothers with previous pregnancies seems to be a risk factor for subsequent perinatal loss due to GBS. Of 17 pregnancies among these 11 mothers, only 3 resulted in living children. Colonized mothers with GBS are usually treated late in the third trimester, if at all. This study indicates that attention must be directed to midgestation, at least among the high-risk group.

Female↗
PubMed1984

Coagulase-negative staphylococcal bacteremia in newborns.

Coagulase-negative staphylococci (C-NS) recently have been identified as common causes of septicemia in high-risk newborns. In this review of the incidence and clinical significance of C-NS blood culture isolates from infants with suspected septicemia in a newborn intensive care unit (NICU), 2.2 percent of blood cultures in an 18-month period yielded C-NS. Based on the criterion of growth in multiple blood cultures as evidence of bacteremia, six of 30 infants (20%) were bacteremic, 17 (57%) represented probable contaminants (on the basis of growth in only one of two paired blood cultures with CN-S), and seven cases (23%) were indeterminant (only one culture was obtained). In those infants considered bacteremic, onset occurred between 12 and 51 days of age. In those with probable contaminants, all but three occurred in the first week of life. All infants had manifestations of suspected sepsis and survived the clinical episode. These findings indicate that C-NS growth can be due to nosocomial bacteremia but frequently represents blood culture contamination, especially in infants in the first week of life. At least two paired peripheral blood cultures should be obtained in infants with suspected septicemia to differentiate bacteremia from contamination.

Bacteriological Techniques↗
PubMedDate not supplied

Pseudomembranous colitis in a preterm neonate.

This preterm female infant abruptly developed diarrhea and bowel distention at 25 days of age and died within 60 h with fulminating pseudomembranous colitis and proctitis. Toxin-producing C. difficile was recovered from the stool. The pseudomembranous colitis developed 12 days after the last dose of ampicillin was given to the baby. Necrotizing enterocolitis, a condition pathologically distinct from pseudomembranous colitis, was also present.

Ampicillin↗