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Biomedical subjects

P Capone

Publications and source records attributed to P Capone.

27 records · Page 2Linked to original sources
PubMed1983

Multicenter dose-response study of the effect of indapamide in the treatment of patients with mild to moderate hypertension.

This study, carried out in three centers in the United States, investigated the antihypertensive effect of three dosages of indapamide in 87 patients with mild to moderate hypertension. The dosages studied were 1 mg, 2.5 mg, and 5 mg daily. A double-blind, parallel study design was used with a six-week placebo run-in period followed by an eight-week treatment period and a two-week follow-up period. Compared with placebo, all dosages caused a significant decrease (P less than 0.05) in blood pressure, with an average decrease of approximately 6 mmHg diastolic and 13 mmHg systolic. The antihypertensive effect seemed to be fully manifest after six weeks of treatment. At all dosage levels, indapamide produced markedly greater therapeutic success rates than did the placebo. Success was defined as either a standing phase-5 diastolic blood pressure of less than 90 mmHg or a decrease by at least 10 mmHg from baseline. Although the decrease in mean serum potassium concentration was dose-related, the decrease was not clinically significant with any dose. A reduction in serum chloride and increases in serum uric acid and glucose were also observed. These changes were slight and did not cause the discontinuation of treatment for any patient. The most frequently observed side effects were mild to moderately severe dizziness, weakness, and headaches.

Adult↗
PubMed1980

[Statistical studies of street traffic noise in the city of Pescara, based on findings on 24-hour periods].

The level of acoustic pollution from road traffic in Pescara has been measured in 10 residential areas with commercial activity. Measurements have been carried out during 24 hours, by means of a magnetic recorder Nagra IV-SJ, joined with a statistic level analyzer Brüel & Kjaer 2312 in connection with an alpha digital printer. Cumulative statistic levels, standard deviation, equivalent level, noise pollution level and traffic noise index, have been calculated. Composite indexes of acoustic pollution expressed as equivalent level 24 hours (Leq 24), level day-night (Ldn) and composite noise equivalent level (CNEL) have been calculated elaborating the data obtained. All collected data resulted to exceed the limits of stated rules.

Automobiles↗
PubMedDate not supplied

[Atrial fibrillation induced by massage of the carotid sinus in patients with orthodromic reciprocal supraventricular tachycardia and Wolff-Parkinson-White syndrome].

A 46 years old man with WPW syndrome, due to a posteroseptal accessory pathway, was admitted because of orthodromic reciprocating tachycardia, 210/m'in frequency. At the end of the carotid sinus massage, for accomplish the conversion of tachycardia to sinus rhythm, the orthodromic reciprocating supraventricular tachycardia degenerated into atrial fibrillation associated with high ventricular rate and the presence of hemodynamic instability, reverted to sinus rhythm by intravenous propafenone. Vagal stimulation, induced by carotid sinus massage, probably caused dispersion of atrial refractorines and intraatrial reentry, converting the orthodromic tachycardia into atrial fibrillation. The transesophageal electrophysiologic study, executed in treatment with propafenone, not documented the accessory connection and atrial fibrillation or reciprocating tachycardia were not inducible.

Atrial Fibrillation↗