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Biomedical subjects

P Carpeggiani

Publications and source records attributed to P Carpeggiani.

8 recordsLinked to original sources

MRI of intracranial meningiomas: correlations with histology and physical consistency.

Magnetic resonance imaging (MRI) appearances of 43 intracranial meningiomas were reviewed and correlated with their histology and consistency at surgery and on pathological examination. There was a statistically significant prevalence of hard tumours within the fibroblastic subtypes. No statistically significant correlation between signal intensity and histology or consistency was found. A meningioma hyperintense on T2-weighted images is, however, unlikely to be fibroblastic or hard.

Adult↗

Gadolinium-enhanced nerve roots in lumbar disk herniation.

PURPOSE: To analyze contrast-enhanced features of intrathecal nerve roots in lumbar disk herniation in patients who have not had surgery and to evaluate the possible correlation with herniated disk, peridiscal enhancement, and symptomatology. METHODS: Twenty patients with a syndrome of lumbar herniated disk without surgery were studied with pre- and postcontrast MR imaging. RESULTS: In six patients (30%), ipsilateral intradural roots affected with large disk herniations showed consistent enhancement along their whole length, from the site of compression to the root-medullary junction. This enhancement persisted on delayed scanning. "Selective" enhancement differed from the minimal enhancement seen in normal intrathecal roots in 11 (55%) patients. Enhancement around herniated disks was a common finding (92% of patients) and did not correlate with selective or normal root enhancement (P > .05). No symptom differences were found among patients with and without selective enhancement. CONCLUSION: Selective intrathecal root enhancement seems to be the direct visualization of the radiculopathy resulting from disk herniation. It is probably a transient event more likely to be noted in the acute phase. Although there is no evidence of immediate clinical utility of this finding, gadolinium-enhanced MR gives insights into the basic pathophysiologic alterations involved in degenerative disk disease.

Adult↗

Leptomeningeal carcinomatosis presenting as progressive multineuritis: clinical, pathologic, and MRI study.

Two patients developed a persistent illness characterized clinically and electrophysiologically by asymmetric involvement of spinal roots, of cranial and peripheral nerves. In the first case the disease was not discovered clinically but only after autopsy. The primary neoplasm remained undetected at autopsy. There was profound infiltration of the leptomeninges by tumor cells with features of metastatic adenocarcinoma. In the second patient onset of neurological symptoms occurred 16 years after surgery for breast cancer, which may be reasonably considered the primary malignancy-CSF cytology was positive only in the second patient in whom Gd-DTPA MRI supported the diagnosis. Our cases demonstrate that diagnosis in leptomeningeal carcinomatosis may be a challenging clinical problem.

Carcinoma↗