Persistent hiccups induced by dexamethasone.
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Adult↗
Biomedical subjects
P Casner
Publications and source records attributed to P Casner.
Abortion procedure.
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Abortifacient Agents, Steroidal↗
Profile of HIV disease in an American border city.
A previous study on patterns of migration of HIV-infected persons suggested that most patients in a rural setting in eastern Tennessee acquired their disease in an urban area, typically during a period of prolonged residence. Disease and disability were the most common reasons for returning to their hometown. We studied our urban, border-city HIV clinic population to see whether similar patterns of migration were discernible. Fifty-one of the 103 patients studied lived outside the El Paso/Juarez area when they contracted HIV infection. The major reason cited for returning home was a desire to return to family (25%). Those who returned and those who had never left showed no statistically significant difference in age, race, or risk factors. This study suggests that migration of HIV-infected patients back to their hometown does not appear to be an exclusively rural phenomenon.
Acquired Immunodeficiency Syndrome↗
Individualized pharmacokinetic versus standard dosing of amikacin: a comparison of therapeutic outcomes.
We compared the therapeutic outcome in patients with normal renal function managed with either individualized pharmacokinetic (PK) dosing or standard (every 12 h) dosing of amikacin. A total of 82 patients with confirmed or suspected infectious processes were entered into the study. There was no difference in therapeutic outcomes (P = 0.47) with one patient from each group dying. The duration of hospital stay (15.8 days vs 11.3 days, P = 0.052) and the mean duration of therapy (8.9 days vs 7.4 days, P = 0.20) were not significantly different, although a trend was seen towards longer time periods in the PK group. The incidence of nephrotoxicity (3 vs 1, P = 0.61), and calculated PK parameters were not different between the PK and standard groups, respectively. Upon evaluation of amikacin serum concentrations in individual patients, we found that five of 82 patients (6.1%) were or might have been at risk for toxicity with standard, unmonitored doses of amikacin, when compared to published literature. Although equivalent therapeutic outcomes may be achieved with standard or individualized PK dosing, the risk of toxicity with standard dosing is substantial. The routine use of standard dosing regimens cannot be recommended. Definition of specific patients subtypes in whom standard regimens utilizing lower doses can safely and effectively be used is necessary.
Adolescent↗
Renin-angiotensin role in thirst: paradoxical enhancement of drinking by angiotensin converting enzyme inhibitor.
A competitive angiotensin converting enzyme antagonist SQ 20, 881 (SQ), was used to examine the role of the renin-angiotensin system in putative renin-dependent thirst in the albino rat. Significant enhancement of "renin-dependent" as well as renin-independent drinking was observed in the presence of peripheral SQ. Intraventricular SQ obviated this enhancement of drinking but did not affect the water intake caused by the original stimulus itself, whereas it sharply reduced drinking evoked by peripheral renin in nephrectomized rats. Prior renin depletion likewise had no influence on so-called renin-dependent thirst.
Angiotensin II↗