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Biomedical subjects

P Chalmers

Publications and source records attributed to P Chalmers.

10 recordsLinked to original sources

Group aggregates and individual reliability: the case of verbal short-term memory.

Two experiments examined the generalizability of the effects of word length and phonological similarity with visual and auditory presentation in immediate verbal serial ordered recall. In Experiment 1, data were collected from 251 adult volunteers drawn from a broad cross-section of the normal population. Word length and phonological similarity in both presentation modes significantly influenced the group means. However, 43% of the subjects failed to show at least one of the effects, and the likelihood that effects appeared was highly correlated with verbal memory span. In Experiment 2, 40 subjects of the original sample were retested, 20 of whom had failed to show one or more effects in Experiment 1. Whether or not an effect had appeared for individual subjects on the first test session was a poor predictor of whether the effect would appear on retest. Finally, an analysis of subject reports demonstrated that the patterns of experimental data could be accounted for in part by the strategies that subjects reported using, and the effect of strategy was independent of the effect of span. The implications of these findings for theories of verbal short-term memory are discussed.

Acoustic Stimulation

Comparison of sonotubometry with tympanometry to assess eustachian tube function in adults.

Eustachian tube dysfunction is thought to be one of the most important factors in the development of middle ear effusions. Direct measurement of Eustachian tube opening is not widespread in clinical practice. Evaluation of a new, small and cheap sonotubometer was carried out on 50 volunteers. The results were compared with the measurement of Eustachian tube function by tympanometry and show a high degree of correlation (P less than 0.001).

Acoustic Impedance Tests

Oral bromazepam in premedication. A comparison with diazepam.

Bromazepam, a relatively newly benzodiazepine with marked anxiolytic effects, was compared in a randomised, double-blind manner with diazepam for its effectiveness as an oral premedicant drug. A scoring system was used to assess sedation, relief of anxiety, nausea, and cardiovascular effects in two groups of women having gynaecological operations. No difference was demonstrated between the effectiveness of the two drugs.

Administration, Oral

Field outbreaks of hyperoestrogenism (vulvo-vaginitis) in pigs consuming maize infected by Fusarium graminearum and contaminated with zearalenone.

During the spring and summer of 1979 field outbreaks of porcine hyperoestrogenism characterized by swelling and reddening of the vulva and teats in prepubertal gilts and enlargement of the mammae in young males occurred in the mistbelt of the Natal Midlands. On a farm in the Ixopo district, pigs were fed a mixed ratio containing home-grown yellow maize stored on the cob in a crib and all the young pigs with a mass of 25-85 kg (=a total of 350) were affected. Maize ears from the crib had a high percentage (91%) of kernels infected by Fusarium graminearum and contained 10 mg/kg of zearalenone. The mixed ration contained 0,95 mg/kg zearalenone. After dilution of the contaminated maize with good quality white maize, a dramatic decrease in both the incidence and severity of clinical signs occurred within 3-4 days. On a farm in the Winterton district, approximately 80% of the growing pigs with a mass of more than 40 kg fed a mixed ration containing shelled yellow maize from the silo of the local Agricultural Co-operative were affected. The incidence as well as the severity of the swelling of the vulvas and/or treats were lower than on the farm at Ixopo, thus indicating a lower level of oestrogen intake. A sample of maize from the silo delivered to this farm contained only 0,06 mg/kg zearalenone while the mixed ration did not contain chemically detectable levels of zearalenone. This is the first published record of field outbreaks of porcine hyperoestrogenism associated with the ingestion of F. graminearum infected maize contaminated with zearalenone in the Republic of South Africa.

Animal Feed

Less common "doping" agents and substances encountered during routine screening for drugs.

The chromatographic and spectroscopic properties of several unusual substances which have been detected in the "alkaloidal" chloroform extract from racehorse urine and saliva samples are reported. Some of these substances have been identified by combined gas chromatography-mass spectrometry and the source of the substance is stated where this is known. Other substances whose identity is not known have been detected and their mass spectra show characteristic amine fragments. The occurrence of these unidentified substances is more frequent in aged urine samples and it would therefore appear that they are associated with putrefaction.

Animals