[Changes in the activity of the plasma angiotensin-converting enzyme in patients suffering from Schönlein-Henoch disease].
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Biomedical subjects
Publications and source records attributed to P Chankova.
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The first results from the treatment of two cases with glomerulonephritis are reported--the first was an exacerbation of nephritis after intercurrent disease and second--with systemic lupus erythematosus, after plasmapheresis application as an active therapeutic method, in combination with corticosteroid cytostatic treatment. A reduction of the three immunoglobulins in plasma was found as a result from plasmapheresis and emergence of serum complement, together with clinical data for improvement of the patients. The prospects of plasmapheresis treatment of the active forms of glomerulonephritis are discussed.
Prior to and post hemodialysis, a determination of plasma potassium, sodium, calcium, phosphorus and the indices of acid-base state is performed in 16 patients with chronic terminal renal insufficiency, with 560 hemodialyses, applied once or twice a week with deionized water and dialysis solution with 1, 5 mEq/1 potassium. Considerable hypopotassemia was established after hemodialysis--3, 3 mEq/1 and in 35% of the cases--hypopotassemia under 3.0 mEq/1. Metabolite alkalosis was established after dialysis: elevated pH in blood from 7,353 to 7,491; standard bicarbonates--from 21, 2 to 29, 1 m Eq/1; basis-excess: from (-3, 78) to (+5, 26) mEq/1; buffer bases: from 41, 3 to 51, 0 Eq/1, normalization of the elevated phosphorus in plasma from 7, 4 mg% to 4, 6 mg%. No significant changes in plasma sodium and potassium, as well as pCO2 were established after hemodialysis.
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