PubMed Health⌕ Search

Biomedical subjects

P Chui

Publications and source records attributed to P Chui.

8 recordsLinked to original sources
PubMed2000

7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex.

A number of RNA-binding proteins are associated with mRNAs in both the nucleus and the cytoplasm. One of these, Npl3p, is a heterogeneous nuclear ribonucleoprotein-like protein with some similarity to SR proteins and is essential for growth in the yeast S. cerevisiae. Temperature-sensitive alleles have defects in the export of mRNA out of the nucleus (1). In this report, we define a genetic relationship between NPL3 and the nonessential genes encoding the subunits of the cap-binding complex (CBP80 and CBP20). Deletion of CBP80 or CBP20 in combination with certain temperature-sensitive npl3 mutant alleles fail to grow and thus display a synthetic lethal relationship. Further evidence of an interaction between Npl3p and the cap-binding complex was revealed by co-immunoprecipitation experiments; Cbp80p and Cbp20p specifically co-precipitate with Npl3p. However, the interaction of Npl3p with Cbp80p depends on both the presence of Cbp20p and RNA. In addition, we show that Cbp80p is capable of shuttling between the nucleus and the cytoplasm in a manner dependent on the ongoing synthesis of RNA. Taken together, these data support a model whereby mRNAs are co-transcriptionally packaged by proteins including Npl3p and cap-binding complex for export out of the nucleus.

Biological Transport↗
PubMed1995

Traumatic bronchial rupture--a case report.

Traumatic bronchial rupture is a rarity. Its incidence is about 1.5% to 3% in most series of blunt chest trauma. We report a patient who presented after a road traffic accident with an apparently persistent pneumothorax which failed to respond to emergency treatment. This was later discovered to be due to a traumatic bronchial rupture. It is difficult to diagnose traumatic bronchial rupture, the main reason being that it is often not considered by doctors caring for the patient with blunt chest trauma in the Accident and Emergency Department. Failure to recognise this condition contributes to its high mortality. The authors would like to recommend that emergency bronchoscopy be carried out in patients with blunt chest trauma to exclude this potentially treatable condition. This is especially so if there are suggestive clinical features, such as the presence of extensive and spreading subcutaneous emphysema, pneumomediastinum, pneumothorax, haemoptysis, fractures of the first two ribs and respiratory distress. A history of massive blunt force to the chest wall as a mechanism of injury should also prompt the trauma team to consider the need for emergency bronchoscopy.

Accidents, Traffic↗
PubMed1993

Plastic bag suffocation.

Suffocation by plastic bag is not common. The finding of a body at the scene of death with a plastic bag in situ could be diagnostically valuable to the pathologist. Otherwise the pathologist may be hard put to arrive at a firm opinion as to how the deceased met his/her death; in fact, in three of the cases reported in this paper, the local pathologist could not give a cause of death when the initial autopsy was performed. Plastic bags could be accidentally placed over the head; put there to help in the inhalation of volatile substances; with homicidal intention; or simply as an effective suicidal method. The object of this paper is to study the cases where bodies were found with a plastic bag over the head, and in particular the cases where the cause of death was due to plastic bag suffocation.

Adult↗
PubMed1987

Spontaneous tonsillar haemorrhage: (two cases).

The only cases of spontaneous tonsillar haemorrhage reported in the past have been associated with Infectious Mononucleosis. We report two cases in which Infectious Mononucleosis was not found as the cause of the haemorrhage.

Adolescent↗
PubMed1987

The influence of temporal bone anatomical variation upon the caloric stimulus.

This study involved a comparison of temperature changes occurring in isolated cadaveric temporal bones as a result of caloric stimulation, with information gained from radiological examination of the bones by means of high resolution computed tomographic scanning. This was performed in order to investigate the complex nature of heat transfer within the temporal bone and the influence which anatomical variations may have upon the accuracy of evaluation of vestibular function by means of the caloric test. No significant correlation could be found between the maximum temperature change occurring across the lateral semicircular canal and any of the parameters obtained from radiological assessment except for the diameter of the internal auditory meatus. It was deduced that an intra-subject difference in the diameters of the internal auditory meatus of 0.5 mm would introduce an absolute error in the evaluation of percentage canal paresis of 10%. Since normal intra-subject differences in internal meatus diameter can exceed 0.5 mm, this finding was considered to be highly significant.

Caloric Tests↗
PubMed1986

The hazards of 'button-sized' batteries as foreign bodies in the nose and ear.

Two cases of button-sized batteries found as foreign bodies, one in the ear and one in the nose, are presented. In both cases extensive local damage had followed delayed removal of the batteries. Urgent retrieval of such foreign bodies is stressed to avoid dangerous sequelae. The possible mechanisms of local tissue necrosis and subsequent complications are discussed.

Child↗
PubMedDate not supplied

Isolated subglottic lymphoma: an interesting cause of dysphonia.

Isolated laryngeal lymphomas are exceedingly rare tumours: they tend to be greyish submucosal swellings and to respond well to radiotherapy. A case of subglottic lymphoma is presented, along with a review of previously reported cases of subglottic lymphomas.

Aged↗