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Biomedical subjects

P Clarysse

Publications and source records attributed to P Clarysse.

4 recordsLinked to original sources

Tracking geometrical descriptors on 3-D deformable surfaces: application to the left-ventricular surface of the heart.

Motion and deformation analysis of the myocardium are of utmost interest in cardiac imaging. Part of the, research is devoted to the estimation of the heart function by analysis of the shape changes of the left-ventricular endocardial surface. However, most clinically used shape-based approaches are often two-dimensional (2-D) and based on the analysis of the shape at only two cardiac instants. Three-dimensional (3-D) approaches generally make restrictive hypothesis about the actual endocardium motion to be able to recover a point-to-point correspondence between two surfaces. The present work is a first step toward the automatic spatio-temporal analysis and recognition of deformable surfaces. A curvature-based and easily interpretable description of the surfaces is derived. Based on this description, shape dynamics is first globally estimated through the temporal shape spectra. Second, a regional curvature-based tracking approach is proposed assuming a smooth deformation. It combines geometrical and spatial information in order to analyze a specific endocardial region. These methods are applied both on true 3-D X-ray data and on simulated normal and abnormal left ventricles. The results are coherent and easily interpretable. Shape dynamics estimations and comparisons between deformable object sequences are now possible through these techniques. This promising framework is a suitable tool for a complete regional description of deformable surfaces.

Heart Ventricles

[Mesenchymal chondrosarcoma].

A case is presented of mesenchymal chondrosarcoma. This extremely rare tumor has a characteristic histology. The prognosis is poor. Radical surgery is essential. A lifelong follow-up is recommended.

Aged

[Ototopic agents].

In treating ear disease every otolaryngologist is familiar with topical medications. The choice of the ideal agent for a given clinical situation may be difficult. In order to make this decision more easy, we overlook the composition of ear-drops. The most important disadvantages are ototoxicity, allergy and pain. The place of ototopical agents in otitis externa, otitis media and otomycosis is discussed.

Administration, Topical

Validation of a new method for stereotactic localization using MR imaging.

Magnetic resonance is recognized as potentially the best imaging procedure for localization in stereotactic neurosurgery. However, special difficulties necessitate specific adaptation to localize targets in the stereotactic frame. We developed a new method for stereotactic localization. The MR studies were performed using a 0.5 T imager. Four small boxes filled with CuSO4 solution were inserted into the intracranial holders of a Talairach frame. Using fast sequences, thirty 7-mm thick contiguous sagittal slices and twenty 5-mm thick axial slices enabled us to image the entire brain. The image data were transferred for analysis to an image processing station, including special software to handle stereotactic calculations. The accuracy of the origin of the trihedron and systematic geometrical errors were carefully evaluated using a cubic phantom, and corrective algorithms were applied when needed. Moreover, checks have been designed to detect geometrical distortion due to ferromagnetic artifacts, alterations in gradient calibration, or movements made by the patient. This localization method does not necessitate the use of stereotactic frames and appears to be precise enough for clinical use. Duration of MR examination is not a restricting factor, mainly because the patient can be positioned easily.

Calibration