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Biomedical subjects

P Clyburn

Publications and source records attributed to P Clyburn.

5 recordsLinked to original sources
PubMed1994

Relative potency of vecuronium in male and female patients in Britain and Australia.

We compared the potency of vecuronium when given to similar patients in Brisbane, Australia, and Cardiff, United Kingdom. Forty patients in each centre were anaesthetized using the same technique with propofol, fentanyl, nitrous oxide and vecuronium either 20 or 30 micrograms kg-1 by random allocation. Neuromuscular block was measured with similar Datex Relaxographs. There was no significant difference in potency between British and Australian patients. The ED50 and ED95 for a British male of average weight were 29.5 micrograms kg-1 (95% confidence limits 27.3-32.3 micrograms kg-1) and 51.3 micrograms kg-1 (44.3-63.9 micrograms kg-1), respectively. ED50 and ED95 for Australians were 5.5% greater, with confidence limits from 4% less to 17% greater. Females were significantly more sensitive to vecuronium than males, requiring 22% less drug to achieve the same degree of neuromuscular block (confidence limits 12-32%). The results are consistent with the ED50 being independent of body weight when the dose is expressed as microgram kg-2/3, but not as microgram or microgram kg-1.

Adolescent↗
PubMed1992

Epidural pethidine and bupivacaine in labour.

A double-blind randomised study was performed to assess the value of the addition of pethidine 50 mg to the initial dose of bupivacaine given for epidural analgesia in labour. Forty-nine patients received either 1 ml of saline (n = 24), or 50 mg of pethidine (n = 25), added to 9 ml of 0.25% bupivacaine as an initial injection for intrapartum epidural analgesia. There was a significant increase in the mean duration of analgesia in the pethidine group. However, pethidine did not increase the speed of onset of analgesia, or improve the quality of analgesia.

Adult↗
PubMed1986

Effects of diazepam and midazolam on recovery from anaesthesia in outpatients.

Sixty patients were randomly allocated in an open study to receive either midazolam or diazepam (Diazemuls) with fentanyl and etomidate for induction and maintenance of anaesthesia during day-stay gynaecological surgery. The excitatory effects of etomidate were controlled by the benzodiazepine-fentanyl combination in both groups. No significant difference in the quality of recovery (as judged by Trieger test analysis), amnesia, incidence of recall of pain on injection of etomidate or nausea and vomiting could be demonstrated between the groups. There was a high degree (97%) of patient acceptance.

Adult↗