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Biomedical subjects

P Codoñer Franch

Publications and source records attributed to P Codoñer Franch.

6 recordsLinked to original sources
PubMed1999

[Gastric emptying in children with gastroesophageal reflux. Evaluation by real time ultrasonography of the pyloric antrum].

OBJECTIVE: We have studied gastric emptying using real time ultrasound in 25 healthy children and 25 children with RGE. Our aim was to establish the time and mode of gastric emptying and the volume and the degree of antral dilation in both groups at baseline and after a test meal. We also evaluated the same parameters in the RGE cases after supplying a prokinetic. PATIENTS AND METHODS: The Bolondi technique was used to measure the basal antrum volume and emptying ratio, as well as the mode and final gastric emptying time at different time-points after a solid-liquid test meal. RESULTS: Patients with RGE have a clearly longer gastric emptying time with respect to the healthy subjects in both children less than one year of age (238 +/- 48.4 vs 176.3 +/- 36.7 minute; p = 0.03) and those 1-14 years old (206.3 +/- 48.2 vs 163.3 +/- 48.1 minutes, p = 0.03). An anomalous gastric emptying, similar to a broken line, can be observed in children suffering from RGE. In contrast, a progressive reduction of antrum dilation ration was seen in healthy children and not in patients with RGE. After cisapride, gastric volume goes down at all test times in RGE children. Therefore, a decrease in final gastric emptying time cannot be observed. CONCLUSIONS: Children suffering from RGE show an alteration in gastric emptying with a clearly greater time and an anomalous mode of emptying. The antrum remained dilated for longer periods after ingestion of test food.

Adolescent↗
PubMed1998

[Cholestatic-type hepatitis in childhood].

OBJECTIVE: The aim of this study was to evaluate the incidence, etiology, clinical evolution and prognosis of cholestatic hepatitis during childhood. PATIENTS AND METHODS: A retrospective study of 145 children hospitalized for acute hepatitis between December 1983 and September 1996 were studied. Cholestatic hepatitis was defined by a direct bilirubin higher than 50% of the total bilirubin. RESULTS: Five cases were identified, which represents 3.45% of all hospitalized hepatitis cases. The average age was 8 years. Cholestatic symptomatology was predominant in all cases with bilirubin values ranging from 10.5 to 32 mg/dl. Cytolysis ranged from moderate to intense. Regarding enzymes indicating cholestasis, the most elevated was 5'nucleotidase, followed by GGT. Quick's index was abnormal in 2 cases, one of which was not corrected by vitamin K. Cholesterol, triglycerides and gamma globulins were slightly increased. In only one case was there a thickening of the wall of the vesicula, which was dilated. Three cases corresponded to hepatitis A virus, one to hepatitis B virus and SMA (smooth muscle autoantibodies) were identified in the fifth. Evolution was favorable in all patients within 8 weeks, except for a girl with subacute hepatocellular insufficiency (SMA positive) where a normal state was achieved 3 months after immunosuppression treatment was started. CONCLUSIONS: 1) Cholestatic hepatitis is an infrequent form of acute hepatitis evolution in childhood and can be promoted by hepatitis virus A or B. 2) It shows a favorable prognosis, except when it comes from a non-viral etiology.

Acute Disease↗
PubMed1989

[Anti-endomysium antibodies: new serological markers for the diagnosis and follow-up of patients with gluten-sensitive enteropathy. Preliminary study].

The authors value the parameters of diagnostic efficacy in a preliminary study of anti-endomysium antibodies (EmA), in the diagnostic and follow-up of patients with gluten sensitive enteropathy. The study was made with 84 subjects distributed into four groups. Group I consisted of 21 patients with gluten sensitive enteropathy (GSE) who were eating gluten at the time of diagnosis. Group II consisted of 20 patients with gluten sensitive enteropathy with different periods of time of gluten free diet. Group III consisted of 16 subjects with non-evolutive neuropathies and without intestinal disease. This group was considered as controls. Group IV consisted of 27 patients with toddler diarrhoea. The sensitivity, specificity, positive predictive value, negative predictive value and efficiency were 100%.

Autoantibodies↗
PubMed1988

[Therapeutic results in Giardia lamblia infestation].

Therapeutic effects of metronidazole (Flagyl), tinidazole (Tricolam 500) and chlorhydrate of quinacrine in a study of 106 children with symptomatic giardiasis are compared. To evaluate results, cure percentage, efficacy and presence of secondary effects were quantified. Tinidazole was demonstrated most effective drug (96% effective) when compared with quinacrine (83.3% effective) and metronidazole (70.2%) (p less than 0.05). Authors recommend following regime: tinidazole 50-75 mg/kg divided in 2-3 doses, one day; chlorhydrate of quinacrine 6 mg/kg/day divided in 3 doses, five days; metronidazole 15-20 mg/kg/day divided in 3 doses, seven to ten days.

Child↗