Electro-optical properties of nucleic acids and nucleoproteins. V. Study of sonicated DNA and nucleohistone solutions.
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Animals↗
Biomedical subjects
P Colson
Publications and source records attributed to P Colson.
[Limitation of movements of the elbow in burn patients: capsulo-ligamentary retractions].
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Ankylosis↗
[A case of dorsal burns of the hand. Tissue contracture. Grafts and flaps].
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Adult↗
[The collagen-mucopolysaccharides association observed by the electron microscope].
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Collagen↗
[Clinical and ultrastructural study of fragmented skin grafts].
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Humans↗
[Action of ultrasound on the molecular characteristics of thymus nucleohistones].
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Animals↗
[Dorsal burns of the hand. Problems raised by secondary repair of web space area].
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Burns↗
[The dermo-epidermal flap. Its biological behavior: the flap-graft. Its use in hand surgery].
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Burns↗
[Study of degradation products of calf thymus deoxynucleoprotein].
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Animals↗
[Use of thinned flaps (flap-grafts) in reparative hand surgery].
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Hand Injuries↗
[Recovering burns. Current modified technics. Indications].
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Burns↗
[Ulcerated epithelioma of the back of the hand, a metastasis with exceptional localization, remaining a single metastasis for several years, in a patient operated 30 years earlier for cancer of the breast].
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Aged↗
[Primary and total defatting of autoplasty flaps from a distance].
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Adipose Tissue↗
[Burns of the dorsal side of both hands. Secondary plastic repair. Remote results].
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Adult↗
[Reparative surgery for a burn of both hands].
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Adolescent↗
[Severe mutilations of the hands in an extensively burned patient].
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Adult↗
Design of a sequence-specific DNA-cleaving molecule which conjugates a copper-chelating peptide, a netropsin residue, and an acridine chromophore.
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Acridines↗
Antitumor combilexin. A thiazole-containing analogue of netropsin linked to an acridine chromophore.
We report the synthesis, DNA-binding properties and antitumor activity of ThiaNetGA, a hybrid molecule in which are conjugated a thiazole-lexitropsin and an intercalating anilinoacridine chromophore. This combilexin molecule binds to DNA via a bimodal process involving minor groove binding of the lexitropsin moiety and intercalation of the acridine moiety. The uptake and distribution of the hybrid in L1210 leukemia cells were investigated by ESR spectroscopy using a spin-labeled derivative. The nitroxide-containing conjugate accumulates preferentially in the cell nuclei and rapidly saturates the nuclear receptor sites. Both in vitro and in vivo assays indicate that the drug is practically nontoxic but exhibits moderate antitumor activity against P388 leukemia cells in mice.
Acridines↗