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Biomedical subjects

P Conley

Publications and source records attributed to P Conley.

9 recordsLinked to original sources
PubMed2000

A computational approach to modeling population differences.

Four experiments were conducted to determine whether the Hyperspace Analogue to Language (HAL) model of semantic memory could differentiate between two different populations. An analysis of the differences in densities (or average distances between word neighbors in semantic space) in HAL matrices--generated from text corpora derived from younger and older adults--confirmed that HAL was able to distinguish between the two age groups. This difference was again detected when structured interview data were used to build the corpora. A third experiment, designed to test the specificity of HAL in detecting differences between groups, did not detect any difference in the densities of the memory representations when older adults generated both the test corpora. The final experiment, conducted on the language of adults with Alzheimer's and normal adults, again demonstrated that HAL could discriminate between the two populations. These results suggest that HAL is capable of modeling, on the basis of changes in mean density, some of the differences between populations without modifying the model itself but, rather, by changing the text corpus from which the model creates its representations in semantic space.

Adult↗
PubMed1999

Harm reduction: concepts and practice. A policy discussion paper.

This paper provides an overview of the context, definition, and key features of the harm reduction approach, and provides several examples of current programs in various countries. Both licit and illicit drugs are included in these illustrations. Some of the critical issues, and the strategies needed to advance harm reduction, are discussed. [Translations are provided in the International Abstracts Section of this issue.]

Canada↗
PubMed1999

Large-scale databases of proper names.

Few tools for research in proper names have been available--specifically, there is no large-scale corpus of proper names. Two corpora of proper names were constructed, one based on U.S. phone book listings, the other derived from a database of Usenet text. Name frequencies from both corpora were compared with human subjects' reaction times (RTs) to the proper names in a naming task. Regression analysis showed that the Usenet frequencies contributed to predictions of human RT, whereas phone book frequencies did not. In addition, semantic neighborhood density measures derived from the HAL corpus were compared with the subjects' RTs and found to be a better predictor of RT than was frequency in either corpus. These new corpora are freely available on line for download. Potentials for these corpora range from using the names as stimuli in experiments to using the corpus data in software applications.

Databases as Topic↗
PubMed1998

A submaximal treadmill test for developing target ratings of perceived exertion for outpatient cardiac rehabilitation.

For patient populations whose heart rates cannot be used to regulate exercise intensity, the Borg Rating of Perceived Exertion (RPE) Scale is the preferred way to prescribe exercise intensity. Individual perceptual variations are best quantified by measuring perceptual intensity during maximal exercise testing; however, many situations require a submaximal protocol. Here, a submaximal treadmill procedure for establishing individualized target Ratings of Perceived Exertion is described. Target ratings of exertion were developed for outpatient cardiac rehabilitation patients using the new method and compared to target Ratings of Perceived Exertion obtained using standard techniques. A total of 144 target ratings at intensities ranging from 50% to 85% VO2max were compared. Over-all, the average difference between the two methods was 0.27 units and was not significant at any intensity. Therefore, the Treadmill Slope Method appears to be a valid submaximal test for generating target Ratings of Perceived Exertion for outpatient cardiac rehabilitation patients.

Ambulatory Care↗
PubMed1996

Three-point method of prescribing exercise with ratings of perceived exertion is valid for cardiac patients.

It is often difficult to use heart rate to prescribe exercise for cardiac patients due to the effects of medications and procedures such as cardiac transplantation. Ratings of Perceived Exertion (RPE) is the preferred method of regulating exercise intensity in these situations. An RPE-based exercise prescription has previously depended on perceptual data from a maximal Graded Exercise Test (GXT). Recently, using 13 healthy subjects, we validated a Three-point RPE for prescribing exercise using RPE which can be used when ratings from a GXT are not available Currently, we examined the accuracy of this method for developing target RPEs for patients in Phase II cardiac rehabilitation. Such target RPEs did not differ from those obtained using standard procedures. We conclude that the Three-point Method is valid for preparing RPE-based exercise prescriptions for Phase II cardiac rehabilitation patients.

Adult↗
PubMed1995

Responses of 3-dimensional arch wires to vertical v-bends: comparisons with existing 2-dimensional data in the lateral view.

The mechanics of V-bends in orthodontic arch wires have been described almost exclusively in terms of bending forces in two-dimensional (2-D) single plane terms. When a rectangular arch wire enters a third dimension, a more complex wire deformation pattern develops from both torsion and bending during the activation of the V-bends. The necessity for a rectangular three-dimensional (3-D) arch wire to undergo torsion during activation results in a greater resistance to deformation at those points in the wire where the torsion is greatest. This is especially apparent with 2 x 2 long span arch wires. This study used finite element analysis to model the force systems produced by activation of V-bends in 3-D arch wires. In both 2-D and 3-D data, greater moments are present as any V-bend is moved toward either adjacent bracket. In 3-D systems, however, a V-bend at the molar produces significantly less moment and associated equilibrium forces than the same V-bend located the same distance from the incisor. Moreover, the reversal of the direction of the moments at either bracket does not occur when the V-bend location is two thirds of the distance toward that tooth as reported with 2-D studies.

Computer Simulation↗
PubMed1994

Structure and expression of the human slow twitch skeletal muscle troponin I gene.

The contractile protein troponin I is encoded by a multigene family whose members are expressed differentially in various classes of muscle fibers. In vertebrates, the "slow" isoform of troponin I is expressed during early heart and skeletal muscle development but is restricted to slow twitch skeletal muscle in the adult. This diverse expression pattern offers an opportunity to study the regulation of a single gene within different developmental contexts. To initiate such studies, we have cloned the gene encoding the human slow twitch skeletal muscle isoform of troponin I and have identified 5'-flanking sequences required for its expression in skeletal muscle cells. The slow troponin I gene spans 12.5 kilobases and is divided into nine exons. In contrast to many muscle-specific genes, the troponin I promoter does not contain consensus CCAAT or TATA elements. Moreover, the sequence from -9 to +11 resembles an "initiator element" previously shown to direct transcription of some tissue-specific genes lacking TATA boxes (Smale, S. T., and Baltimore, D. (1989) Cell 57, 103-113; Brand, N. J., Petkovich, M., and Chambon, P. (1990) Nucleic Acids Res. 18, 6799-6806; Weis, L., and Reinberg, D. (1992) FASEB J. 6, 3300-3309). A transcriptional fusion construct, comprising 4.2 kilobases of troponin I 5'-flanking DNA linked to the bacterial chloramphenicol acetyl-transferase gene, exhibited cell type-specific and developmentally regulated expression. A muscle-specific enhancer regulated slow troponin I promoter activity.

Adult↗
PubMedDate not supplied

Age effects in a computational model of memory.

Previous research demonstrates that semantic priming is relatively unaffected by age (Chiarello, Church, & Hoyer, 1985; Howard, 1988). To determine how age might affect representations in the HAL model of memory, the authors gathered text from older and younger adults and generated a global co-occurrence matrix for each. An analysis demonstrated that, as in humans, there was little difference in measures of semantic priming between memory matrices constructed from the two corpora. However, the authors discovered that semantic word neighborhoods generated by the older adult corpus were denser than corresponding neighborhoods derived from the younger adult corpus. This result has implications for changes in the semantic representation of words due to the aging process.

Adult↗