PubMed Health⌕ Search

Biomedical subjects

P Conn

Publications and source records attributed to P Conn.

15 recordsLinked to original sources
PubMed1990

Effect of laryngeal stenting in a rabbit model.

A short length of oversize endotracheal tube was sutured in the undamaged subglottis of 22 rabbits to explore the effect of laryngeal stents. The stent was secured to lie beneath the vocal cords. The histologic changes were minimal irrespective of the type of tube used and how long it remained in situ. These findings are consistent with the theory that tube movement is necessary to produce stenosis and are encouraging given the widespread use of stents in pediatric laryngeal reconstruction. The role of gastric acid in producing subglottic stenosis is discussed.

Animals↗
PubMed1989

The use of alcohol-stored cartilage in experimental laryngotracheal reconstruction.

Alcohol-stored homograft ear cartilage was used to reconstruct the larynx in an animal model. When sacrificed after one month the cartilage was incorporated in a stable position with mucosa on the luminal surface. Some resorption of implanted cartilage occurred, particularly where surgical trauma or sutures allowed granulation tissue to penetrate into the matrix. This paper emphasises the role that cartilage damage plays in resorption and strives to improve results in laryngotracheal reconstruction by highlighting the situations in which graft damage can be significant.

Absorption↗
PubMed1987

Cognitive functioning in albino children.

Twelve albino children with IQs in the normal range were psychometrically assessed and compared to a control group of equally visually handicapped children who were non-albino. A striking and consistent pattern of cognitive functioning emerged in the albino group (a large verbal/performance discrepancy in favour of verbal skills) which could not be attributed to their poor visual acuity. This unusual pattern of intellectual functioning may be related to the unique neuroanatomy and neurophysiology recently demonstrated in people with albinism.

Adolescent↗
PubMed1986

Experimental induction of rheumatoid factor and joint lesions in rabbits after intravenous injections of killed bacteria.

Rabbits receiving repeated intravenous injections of killed bacteria (Escherichia coli or Bacillus subtilis) developed IgM rheumatoid factor which reacted with autologous heat-aggregated IgG. In addition, 5/7 'Old English' and 7/8 'Sandy Lop' rabbits receiving killed E. coli developed rheumatoid-like synovial lesions. 'Old English' rabbits developed lesions of a more severe nature. Three of eight 'Sandy Lop' rabbits injected with killed B. subtilis had high levels of rheumatoid factor but only mild joint lesions.

Animals↗
PubMed1986

Synovitis associated with serum IgM rheumatoid factor arising spontaneously in 'Old English' rabbits.

This paper reports the spontaneous development of synovitis in 'Old English' rabbits concurrent with serum IgM rheumatoid factor. Female rabbits developed lesions at a higher incidence than males (42% compared with 17%) and the pathology was of a more severe nature. In the female rabbits synovitis was associated with concurrent high serum IgM rheumatoid factor and high serum antibody levels to Pasteurella multocida. There was no histological evidence that the joints were directly infected.

Animals↗
PubMed1986

Comparison of the arthritogenic properties of dietary cow's milk, egg albumin and soya milk in experimental animals.

The arthritogenic effect of dietary cow's milk, egg albumin and soya milk were compared in Old English rabbits. The 12-week cow's milk feeding regimen produced the highest incidence of significant joint lesions. Lesions were evident but mild at 5 weeks and the synovitis had resolved by 32 weeks. It is suggested that the transient nature of the synovitis may be due to the development of specific secretory IgA antibodies which were detectable in faecal pellet extracts. Sandy Lop rabbits were less susceptible to the arthritogenic effect than were Old English rabbits. Dietary ovalbumin was less arthritogenic than cow's milk despite high titres of serum and synovial fluid antibodies and immune complexes. The rabbits were 'tolerant' to dietary soya due probably to pre-existing levels of soya protein in their diet. Lewis and Wistar strain rats, CBA, Balb/c and C57/BL6 mice fed on cow's milk for 3 months did not develop serum antibodies or synovial lesions. It is suggested that this allergic synovitis is not a model for early rheumatoid joint disease because of the transience of the lesions and lack of stimulation of rheumatoid factor. It may well, however, be a model for the arthralgia seen in patients with certain food allergies.

Animals↗
PubMed1985

Early rheumatoid-like synovial lesions in rabbits drinking cow's milk. I. Joint pathology.

Rheumatoid-like lesions developed in 9 of 25 (36%) Old English rabbits drinking cow's milk for 12 weeks. The incidence of lesions in male and female animals was similar. The majority of rabbits drinking cow's milk developed increased numbers of nucleated cells and raised percentages of T lymphocytes in their synovial fluids, compared to control rabbits. The cell counts and T cell percentages correlated with the severity of the histological lesions. No evidence of glomerulonephritis was observed in any of the experimental animals.

Animals↗
PubMed1985

Early rheumatoid-like synovial lesions in rabbits drinking cow's milk. II. Antibody responses to bovine serum proteins.

Thirty-six percent of Old English rabbits fed pasteurized cow's milk developed early rheumatoid-like synovial lesions. All rabbits drinking milk developed high titres of serum and synovial fluid Clq-binding activity. This has been shown to be due to specific antibody to Clq, produced in response to Clq in cow's milk. In addition, these rabbits responded to other bovine proteins present in cow's milk, including conglutinin, beta-lactoglobulin and IgG. There was no correlation between serum or synovial fluid titres of antibody to bovine milk proteins and synovial lesions.

Animals↗
PubMedDate not supplied

The relations between Griffiths scales assessments in the pre-school period and educational outcomes at 7+ years.

This paper reports an administrative follow-up of 107 children at least 7 years old who were assessed on the Griffiths scales of mental development for clinical purposes when they were aged 4-4.11 years. When Griffiths scale scores are compared with educational status at follow-up, the analyses show that groups of children in settings requiring different levels of learning capacity scored differently on the scales and in line with expectation. There is also evidence of this trend in earlier years. The clinical use of this trend is illustrated.

Achievement↗