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Biomedical subjects

P Consoli

Publications and source records attributed to P Consoli.

7 recordsLinked to original sources
PubMed1992

[Chronic exposure to inhalation anesthetics and immunity].

The existence of a professional disease caused by exposure to general anesthetics has been reported by a number of studies, but opinions still differ as to the effective implications of this type of exposure. The aim of the present study was to analyse alterations in cellular and humoral immunity in anesthetists regularly exposed to general anesthetics. Regression analysis showed that IgA and NK lymphocytes were significantly increased whereas total T lymphocytes reduced in parallel with age and length of service. It can therefore be supposed that the increase in IgA might suggest chronic liver disease, while alterations in the lymphocyte populations, even if closely associated to chronic exposure leading to the hypothesis of a cause-and-effect relationship, do not alter immune system functions since they are similar to those that occur with ageing.

Adult↗
PubMed1985

Iperalimentazione. A program to calculate hyperalimentation needs.

Parenteral hyperalimentation is an important means of nutritional support for critical care patients. Calculation of the amount of calories, components and additives necessary for the appropriate compounding of hyperalimentation solutions is a lengthy, tedious process with many potential opportunities for computation error. A new computer program written in Pascal has been created in order to reduce calculation time and error. Menus and single-keystroke entry are implemented wherever practicable. A review screen is employed to reduce user input errors. A hard-copy printout is generated on command. Program testing has resulted in a 90% reduction in processing time.

Computers↗
PubMedDate not supplied

In vitro release kinetics of Tolmetin from tabletted Eudragit microparticles.

In a previous paper the preparation has been described, by three different techniques, of microparticles made of Eudragit RS 100 and RL 100 containing a NSAI agent, Tolmetin. Freely flowing microparticles failed to affect significantly the in vitro drug release, which displayed a similar dissolution profile after micro-encapsulation to the free drug powder. Microparticles were then converted into tablets and the effect of compression on drug delivery, as well as that of the presence of co-additives, was studied in the present work. Furthermore, microparticles were also prepared by adding MgO to the polymer matrix, to reduce the sensitivity of the drug to pH changes during its dissolution. Similarly, magnesium stearate was also used for microparticle formation as a droplet stabilizer, in order to reduce particle size and hinder rapid drug release. A mathematical evaluation, by using two semi-empirical equations, was applied to evaluate the influence of dissolution and diffusion phenomena upon drug release from microparticle tablets.

Acrylic Resins↗
PubMedDate not supplied

Collection of peripheral blood stem cells by apheresis with continuous flow blood cell separator Dideco Vivacell.

In S. Camillo Hospital, Rome, the Apheresis Center (CNTS-CRI) and the Haematological Division, Authors treated 17 patients affected by haematologic malignances and solid tumours with leukoapheresis procedures for PBSC collection. Nine patients were treated with continuous-flow cell separator Dideco Vivacell, performing a total of 50 collection procedures. Mean values of total collected NC and MNC were 6.5 x 10(9) and 5.5 x 10(9), with a mean recovery 24% and 52%. Authors took patient's blood samples during the procedure, in order to analyze the MNC collection and to optimize the separation efficiency. Haemopoietic reconstitution values of the eight patients submitted to APBSCT showed the effectiveness of our method of cell collection.

Adult↗