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P Coppens

Publications and source records attributed to P Coppens.

48 records · Page 3Linked to original sources
PubMed1988

Equine post anaesthetic myositis: muscular post ischaemic hyperaemia measured by laser Doppler flowmetry.

Measurements of muscular microcirculation in horses anaesthetised with halothane were performed by laser Doppler flowmetry. Variations of microcirculation in the compressed and uncompressed triceps brachii were measured when horses were positioned in dorsal recumbency after a prolonged period in lateral recumbency. A significant post ischaemic hyperaemia was recorded in horses which developed a post anaesthetic myositis.

Anesthesia, Intravenous↗
PubMed1988

The Gram-Charlier and multipole expansions in accurate X-ray diffraction studies: can they be distinguished?

The Gram-Charlier temperature factor formalism has been applied to a set of accurate low-temperature data on bis(pyridine)(meso-tetraphenylporphinato)iron(II), and to a theoretical set of static structure factors on the hexaaquairon(II) ion. The refinements are compared with the multipole treatment for atomic asphericity due to chemical bonding. In a treatment of the experimental data in which only the iron atom asphericity is considered, the 'thermal motion' formalism is as efficient as the multipole formalism in accounting for the observations. It is slightly less efficient when applied to the static theoretical data, though model maps based on the two treatments are remarkably similar. A high-order Gram-Charlier refinement of the porphyrin data, followed by a multipole refinement of all data with the Gram-Charlier parameters initially fixed, and later varied, shows that simultaneous refinement of anharmonic and aspherical effects is possible, though the resulting separation may not be accurate. A combined Gram-Charlier multipole refinement on the static data, however, leads to non-significant thermal parameters. It is concluded that the statistical Gram-Charlier formalism is remarkably successful in representing bonding effects in the valence charge density if these are not specifically accounted for in the scattering formalism. Statistical anharmonic thermal motion formalisms should only be used for X-ray data analysis in combination with a formalism accounting for the effect of bonding on the atomic charge density.

Chemical Phenomena↗
PubMedDate not supplied

Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine.

Rabies infection of domestic and wild animals is a serious problem throughout the world. The major disease vector in Europe is the red fox (Vulpes vulpes) and rabies control has focused on vaccinating and/or culling foxes. Culling has not been effective, and the distribution of five vaccine baits is the only appropriate method for the vaccination of wild foxes. Although some European countries have conducted field vaccination campaigns using attenuated rabies virus strains, their use has not been extensively approved because they retain pathogenicity for rodents and can revert to virulence. These strains cannot be used in North America because they are pathogenic for the striped skunk (Mephitis mephitis) and are ineffective in the raccoon (Procyon lotor). We have constructed a recombinant vaccinia virus, VVTGgRAB, expressing the surface glycoprotein (G) of rabies virus (ERA strain). The recombinant was a highly effective vaccine in experimental animals, in captive foxes and in raccoons. We report here the results of a large-scale campaign of fox vaccination in a 2,200 km2 region of southern Belgium, an area in which rabies is prevalent. After distribution, 81% of foxes inspected were positive for tetracycline, a biomarker included in the vaccine bait and, other than one rabid fox detected close to the periphery of the treated area, no case of rabies, either in foxes or in domestic livestock, has been reported in the area.

Animals↗
PubMedDate not supplied

Subpopulations in closed-head injury: preliminary results.

The classification systems currently utilized to categorize closed-head injury (CHI) patients are all based on severity levels. However, these scales are unable to account for the wide variability among CHI patients. Another way to classify these patients is to use the clinical picture independent of the overall severity level. That approach is used with aphasic patients but not with the CHI population. These preliminary data indicate that there are distinct subgroups in the CHI population. These subgroups can be identified by their overall pattern of performance on a battery of tests covering language, memory, visuospatial, cognitive and discourse skills. The characteristics of the tentative subgroups are described, but a more extensive study is needed to confirm the robustness of this classification.

Adult↗
PubMedDate not supplied

[Experimental model of pulmonary bipartition with bilateral lobe transplantation in dogs and application to clinical medicine].

The crucial need for donors of paediatric or small sized organs has been a great obstacle to overcome in organ transplantation in children or small adults. Some progress in adapting size of the donor organs has been achieved with surgical procedures for reducing the size of donor organs, partial transplantation (single lobe of the liver or the lung) and liver partition, offering a partial solution to the insufficient supply of paediatric organs. We propose an experimental model in the dog of lung partition associated with monolateral (series I) or bilateral (series II) lobe transplantation. The results have been encouraging both in terms of quality of healing and in morphological and functional adaptation of the transplanted lobes, allowing us to apply this technique of lung partition and bilateral lobe transplantation in human patients. The outcome has been excellent in the first case after 18 months follow-up.

Animals↗