PubMed Health⌕ Search

Biomedical subjects

P Coscojuela

Publications and source records attributed to P Coscojuela.

14 recordsLinked to original sources
PubMed2004

High lipoprotein (a), diabetes, and the extent of symptomatic intracranial atherosclerosis.

BACKGROUND: Lipoprotein (a) (Lp[a]) has important atherothrombogenic properties, but its role in intracranial atherosclerosis remains unclear. OBJECTIVE: To investigate the relationship between Lp(a) level and the extent of intracranial large-artery occlusive disease. METHODS: Between June 2001 and August 2003, 166 consecutive first-ever TIA or stroke patients had intracranial stenoses on transcranial Doppler, of which 100 fulfilled all inclusion criteria. The extent of intracranial large-artery occlusive disease was assessed by the number of angiographically confirmed intracranial stenoses. Serum Lp(a) was determined a minimum of 3 months after stroke onset. RESULTS: Two hundred eighty-one intracranial stenoses were documented. Fifty-one (51%) patients had three or more stenoses (greater-extent group). Patients in the highest Lp(a) quartile had a higher adjusted odds ratio (OR) for a greater extent than those in the lowest quartile (OR 3.43, 95% CI 1.04 to 11.33, p = 0.04). A positive correlation was found between Lp(a) concentration and the number of stenoses (r = 0.310, p = 0.002). Moreover, Lp(a) level increased gradually with the number of stenoses (p = 0.02). A multiple logistic regression model identified diabetes (OR 2.4, 95% CI 1.04 to 5.57, p = 0.04) and high Lp(a) (OR 2.52, 95% CI 1.03 to 6.18, p = 0.043) as independent markers of a greater extent of intracranial large-artery occlusive disease. CONCLUSIONS: High Lp(a) level and diabetes mellitus are independent markers of a greater extent of intracranial large-artery occlusive disease. These findings support a role for Lp(a) in intracranial stenotic atherogenesis and might be useful for the selection of high-risk patients.

Aged↗
PubMed1998

[Arteriography using helicoidal computerized tomography in the study of complex aneurysms of the circle of Willis].

INTRODUCTION: Computed tomography angiography (CTA) can add information to digital subtraction angiography (DSA) in selected cases of aneurysms of the circle of Willis. CLINICAL CASES: 1. Patient with progressive visual loss and headache. CT and DSA showed an image of partially thrombosed suprasellar aneurysm. CTA better defined the relationship between the lesion and regional vessels. 2. Woman with subarachnoid hemorrhage (SAH). CTA defined the aneurysmal neck and its relationship to the clinoid process. 3. Man with SAH, CT and DSA showed an arteriovenous malformation and three arterial aneurysms one of which was in a tortuous vessel. CTA confirmed digital angiographic data. CONCLUSION: CTA is a new image technique that can either add or confirm DSA findings in complex aneurysms of the circle of Willis.

Adult↗
PubMed1995

[Intracranial mass as single manifestation of sarcoidosis].

Neurological involvement in sarcoidosis occurs in 5-10% of cases and may adopt a great variety of forms, included space-occupying cerebral masses. The presence of these masses as single G manifestation of the disease, with no evidence of systemic involvement, is uncommon. In a review of the literature we found 15 reported cases and we report here the case of a 74 year-old woman with a parietooccipital mass histologically diagnosed with sarcoidosis, with no evidence of systemic involvement. In most cases masses are supratentorial, evidenced by neuroradiological procedures and diagnosed by means of pathological investigation. Corticosteroids are the therapy of choice because of the favorable outcome of cases so treated.

Aged↗
PubMed1993

Chronic liver disease: comparison of ultrasound patterns with laparoscopy and biopsy.

We studied the correlation of ultrasound patterns with laparoscopy and biopsy results in 140 patients with chronic liver disease (CLD). Of the 23 patients with a normal ultrasound pattern (N), biopsies revealed CLD in 18; in the 22 patients with unspecified hepatomegaly (H), biopsies disclosed CLD in 20; and in the 64 patients with a homogeneous bright pattern (HB), biopsies showed CLD in 62. All 22 cases of heterogeneous bright pattern (HTB) and all 9 patients with nodular pattern (ND) had CLD. In conclusion, it appears that the HTB and nodular ultrasound patterns confirm the presence of CLD, the HB pattern is suggestive of CLD, but diagnosis of CLD cannot be made from N and H patterns.

Adult↗
PubMed1991

Imaging of the azygos lobe: normal anatomy and variations.

We describe the normal appearance of the azygos lobe on plain radiography and CT. Several findings are presented that, to our knowledge, have not been previously reported, such as the inferior prolongation of the fissure, the apparent intrapulmonary path of the right brachiocephalic vein and superior vena cava seen on the anteroposterior chest radiograph, and the visible fissure on the lateral chest radiograph.

Azygos Vein↗
PubMed1990

Aggressive angiomyxoma of pelvic soft tissue: CT appearance.

A case of aggressive angiomyxoma of pelvic tissue is described. The characteristic clinical presenting symptoms together with radiographic findings can be suggestive of this disease. Computed tomography (CT) clearly depicted a solid mass in the pelvis without invasion of visceral structures and reaching caudally into the perineal region.

Female↗
PubMed1989

Echogenic focus in the gastrointestinal wall as a sign of ulceration.

An ultrasound study carried out on 22 patients with ulcerated gastrointestinal lesions (20 adenocarcinomas and 2 peptic ulcers) showed, in all cases, an echogenic focus (EF) that was situated in the gastrointestinal wall. In order to find out the histopathologic significance of this focus and its location, an examination was made "in vitro" of 8 surgical specimens obtained from gastrectomies--6 from peptic and 2 from malignant ulcers. The specimens were immersed in a water bath using a 5-MHz transducer. A common finding in all the specimens was an EF similar to that seen in the clinical study and situated behind the crater of the ulcer. In this location the histopathologic findings demonstrated necrotic and inflammatory material in both the benign and malignant lesions.

Adenocarcinoma↗
PubMedDate not supplied

The growing teratoma syndrome: radiologic findings in four cases.

Radiologic findings in four patients with metastatic mixed germ-cell tumors of the testis are presented. In all cases metastases had increased in size following chemotherapy in spite of normal biomarker levels, and histological study of the residual masses showed mature teratoma with an absence of malignant cells, thus confirming the diagnosis of growing teratoma syndrome. At present CT appears to be the best technique both for diagnosis and follow-up in these patients. In one case, the growing teratoma syndrome presented as cavitation of a pulmonary nodular lesion, a finding rarely described in the literature, and with CT demonstration not reported.

Adolescent↗
PubMedDate not supplied

[Intraventricular hemorrhage due to the rupture of atherosclerotic dissecting aneurysm of the middle cerebral artery].

INTRODUCTION: We present a case of fusiform intracranial aneurysm where, apart from the unusual site, we draw attention to the form of clinical presentation, namely intraventricular haemorrhage. Clinical case. A 68 year-old-man with a history of smoking, hyperuricemia with seizures of gout treated with colchicine and allopurinol, and hypertension treated with captopril. Nine years previously he had a right capsulothalamic haematoma and presented (as a sequela of this) a left sensomotor deficit, with a good functional level. In December 1998 he was admitted for sudden onset of headache and deterioration of consciousness. He had right limb movements which were typical of decerebration and made intubation and mechanical ventilation necessary. Cerebral CT, with angiographic sequences, showed blood in the lateral ventricles and III ventricle, with ventricular dilation and a fusiform aneurysm of the left middle cerebral artery. In view of the neurological state of the patient, treatment of the aneurysm was postponed. After initial improvement, which permitted extubation, tetraparesia (predominantly right) and a pseudobulbar syndrome were seen. The patient had repeated respiratory infections and died from sepsis caused by Pseudomona aeruginosa (of respiratory origin) three months after admission. CONCLUSIONS: Fusiform intracranial aneurysms form 9% of all aneurysms. Localization to the middle cerebral artery is infrequent, the basilar trunk and internal carotid artery are commoner sites. In our case angio-CT was a useful non-invasive neuro-radiological technique.

Aged↗