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Biomedical subjects

P D Barrett

Publications and source records attributed to P D Barrett.

9 recordsLinked to original sources
PubMed2001

Encapsulated fat necrosis: a case of 'thigh mouse'.

Encapsulated fat necrosis is a rare condition with clinical features that closely resemble a lipoma. The aetiology and pathogenesis are not fully understood but the condition has a distinctive histological appearance. We describe a case of encapsulated fat necrosis that exhibited unusual mobility. The literature is also reviewed.

Adult↗
PubMed2001

Merkel cell carcinoma can be distinguished from metastatic small cell carcinoma using antibodies to cytokeratin 20 and thyroid transcription factor 1.

AIM: To investigate whether immunohistochemical staining for cytokeratin 20 (CK20) and thyroid transcription factor 1 (TTF-1) is useful in distinguishing Merkel cell carcinomas (MCCs) from metastatic small cell carcinomas (SCCs). METHODS: Eleven cases of MCC and 10 of lung SCC were stained for CK20 and TTF-1. RESULTS: Ten of 11 MCCs stained with the antibody to CK20. None was positive for TTF-1. No SCC stained with anti-CK20 and all stained strongly with anti-TTF-1. CONCLUSIONS: The use of both anti-CK20 and anti-TTF-1 can reliably distinguish between MCC and metastatic SCC, thus avoiding the need for a detailed clinical investigation of patients with MCC in whom metastatic SCC must be excluded.

Biomarkers, Tumor↗
PubMed1998

Thyroid gland papillary carcinoma with fibromatosis-like stroma: case report.

Papillary carcinoma of the thyroid may show a variable degree of fibrosis of the stroma, but proliferation of the stromal fibroblasts mimicking fibromatosis is rare. There appears to be a new variant of papillary carcinoma of the thyroid associated with exuberant proliferation of the fibroblasts resembling fibromatosis. We present one such case in a 50 year old woman and succinctly reviewed the relevant literature of this rare variant. The necessity of a diligent search for a papillary carcinoma in thyroid gland which shows a proliferative fibrous lesion is stressed.

Carcinoma, Papillary↗
PubMedDate not supplied

Colonic adenocarcinoma presenting as a cutaneous metastasis in an old operative scar.

Cutaneous metastasis from colon cancer is an uncommon event that usually occurs after identification of the primary tumour and generally indicates diffuse disease. Incisional metastasis occasionally occurs following laparoscopic or open colon cancer resection. However, to the authors' knowledge only one previous case of colon cancer presenting as a cutaneous metastasis in an old operative scar has been reported. We describe a case of colon cancer presenting as a cutaneous metastasis in an old cholecystectomy scar and discuss possible pathophysiological mechanisms.

Adenocarcinoma↗