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Biomedical subjects

P D Fomin

Publications and source records attributed to P D Fomin.

At least 19 recordsLinked to original sources
PubMed2006

[Blocking action of pyridoxal-5'-phosphate on nonadrenergic synaptic inhibition of human small intestine smooth muscle].

We investigated the inhibitory synaptic potentials (ISP) in isolated smooth muscle strips of the human duodenum circular layer from the ulcer adjacent region (I group) as well as ileum and distal part of small intestine, which were on a distance of some dozen centimeters from the place of disturbance under the different gastrointestinal diseases (II group). ISP amplitude was several times smaller in the muscle strips of the I group compare to the II group. It could depend on the alterations of smooth muscles cable properties, increase of connective tissue mass, changes in the intestinal nervous system and synaptic transmission in the region adjacent to duodenum ulcer. Pyridoxal-5'-phosphate effectively decreased amplitude and increased ISP latent period in the muscle strips from both groups. N(omega)-nitro-L-arginine, the blocker of NO-synthase did not affect pyridoxal-5'-phosphate activity in smooth muscles. Phosphate group was essential for realization of its influence on ISP in smooth muscles because pyridoxal did not influence both ISP amplitude and ISP latent period.

Adolescent↗
PubMed2006

[Peculiarities of microflora in an acute appendicitis and its impact on the postoperative purulent-inflammatory complications rate].

Bacteriological investigation of processus vermiformis contents was performed in 102 patients suffering an acute appendicitis (AA) and of abdominal cavity exudate--in 82 patients, operated for an AA. The microflora identification was done, as well as probable connection between microorganisms associations, the rate of the AA destructive forms revealing and postoperative purulent-inflammatory complications occurrence.

Acute Disease↗
PubMed2005

[Application of synthetic analogue of somatostatin--octrestatin in the treatment of gastroduodenal erosions and acute ulcers complicated by hemorrhage].

Retrospective analysis of diagnostic and curative processes in Kyiv's city centre of delivering the aid in gastrointestinal hemorrhage for 1131 patients in 1999--2003 yrs period was done. The classification of gastroduodenal erosions and an acute ulcers, complicated by hemorrhage, oriented on etiological factor involved, was proposed. Depending on etiological feature present, there were determined characteristic signs of mucosal affections, their localization and the hemorrhage severity. There was proved the expediency of introduction of the treatment results control, based on investigation of dehydrogenases activity, the intracellular glycogen content and the state of the lipids peroxidal oxidation. Clinical efficacy of synthetic analogue of somatostatin Octrestatin was studied in the treatment of gastroduodenal erosions and an acute ulcers in 26 patients. Application of Octrestatin have promoted the lipids metabolism normalization and acceleration of the mucosal ulcers healing by 2-3 days.

Acute Disease↗
PubMed2005

[Application of anticoagulants in patients after operations for gastro-intestinal bleeding].

Our clinical experience witness the necessity of administration of direct anticoagulants in prophylactic dosage to patients, operated on for gastro-intestinal bleeding. The most effective and secure is preparation of the low molecular weight fractionized heparins group--Fraxparin. The summarized data concerning group of patients, in whom Fraxyparin was applied, witness the absence of unfavourable peak of effect after the preparation injection, gradual action and holding on of the interinjection time plato, the absence of significant additive noncontrollable action of Fraxparin after each subsequent injection made.

Anticoagulants↗
PubMed2002

[Ways for improvement of medical, occupational, and social rehabilitation of patients operated for complicated gastroduodenal ulcer].

Based on the analysis of the early post-operative period in 1588 patients and long-term results in 667 patients having been operated for complicated gastroduodenal ulcers, algorithms are submitted of medical, occupational, and social rehabilitation, which fact permitted improving results of surgical treatment. The proposed rehabilitation project envisages staging and continuity of measures aimed to restore the patients' capacity for work and their social status.

Ambulatory Care↗
PubMed1998

[Effectiveness of the use of solcoseryl after surgery of acute hemorrhage in gastroduodenal ulcer].

The experience of solcoseryl application in 70 patients, operated on for an acute hemorrhage from gastroduodenal ulcer, was summarized. The preparation was injected intravenously in the dose of 10 ml in 5% solution of glucose every other day during 6 days and then in the dose of 5 ml intramuscularly during 4-5 days. High efficacy of solcoseryl, manifesting by more earlier elimination of pain and oedema, healing of mucosa by first intention, shortening of the treatment duration in stationary by 3-5 days, was established.

Actihaemyl↗
PubMed1997

[Surgical treatment of acute peptic hemorrhage associated with perforation of gastroduodenal ulcer].

In 1982-1996 yrs of 8822 patients with ulcer bleeding in 122 (1.4%) it was concurrent with gastroduodenal ulcer perforation. In 34 (27.9%) simultaneous perforation and bleeding were observed, in 88 (72.1%) perforation occurred in 1-7 days after bleeding, in 48 (54.5%) it was concurrent with recurrent bleeding. Postoperative mortality lowered from 25 to 7.1% due to application of the principles elaborated.

Acute Disease↗
PubMed1990

[Internal ligatures of the pyloro-duodenal region after surgical treatment of bleeding ulcers].

1886 fibrogastroduodenoscopic examinations were performed in 820 patients within 7 years after operative treatment of bleeding pyloroduodenal ulcers. Catgut was used in 589 patients for internal sutures in pyloroplasty, the unresolving suture material--capron--was used in 221 patients. Clinico-endoscopic investigations have shown that the application of catgut is followed in the early postoperative period by the development of inflammatory reactions in the tissues along the suture line, while the use of the unresolving suture material is followed by inflammations of less degree, the rejection of internal ligatures was slow with episodes of bleedings, ulcerations, formation of granulomas. The article gives grounds for expedience of removal of internal ligatures during the endoscopic examination of organs in the zone of the operative intervention.

Adult↗