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Biomedical subjects

P D Gorizontov

Publications and source records attributed to P D Gorizontov.

At least 19 recordsLinked to original sources
PubMed1982

[Action of compounds which predominantly affect the peripheral M-cholinoreactive systems on the bone marrow eosinophils].

Experiments on rats have shown that the blockade of M-cholinoreceptors with atropine (50,100 and 150 mg/kg) delays, while the stimulation of the M-cholinoreceptors with aceclidine (5, 10 and 15 mg/kg) intensifies the release of mature eosinophils from the bone marrow to the circulating blood. It is concluded that the peripheral M-cholinoreactive systems participate in the control of the release of the mature bone marrow eosinophils into the blood.

Animals↗
PubMed1980

[Effect of exposure to stress on the role of T- and B-lymphocytes in the response of the hematopoietic system].

Cellular composition of the bone marrow, spleen and peripheral blood was studied after 6-hour immobilization on the back in experiments on 4 groups of (CBAxC57BL)F1 mice with varying degree of T lymphocyte deficiency (thymectomy, sham thymectomy, administration of antilymphocytic serum, B mice). The evidence obtained shows that the "lymphoid peak" recorded in the bone marrow during stress is likely to be formed at the expense of T and B lymphocyte migration from the peripheral lymphoid organs. The data have been also obtained, indicating that T lymphocytes migrating to the bone marrow during the first 6-9 hours after the exposure to stress may participate in granulocytopoiesis activation.

Animals↗
PubMed1976

[Lymphoid tissue and the body's non-specific resistance].

In experiments on rats and mice the author and his pupils showed that nonspecific effect of stimulators brought about in the first hours following the exposure migration of cells from the lymphoid organs, increase in the number of lymphoid cells in the bone marrow by 40-60%, appearance in the bone marrow of T-cells, and increase in the number of hemopoietic cells (CFU). This contributed to the activation of hemopoiesis and to development of transient hyperplasia of the bone marrow to the stage of elevated resistance of the organism. It was shown that transplantation of T-cells performed in the first hours after the sublethal irradiation hastened regeneration of hemopoiesis. All the data indicated above testify to the role of the lymphoid tissue in nonspecific resistance of the organism.

Animals↗