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Biomedical subjects

P D Marsden

Publications and source records attributed to P D Marsden.

At least 73 records · Page 4Linked to original sources
PubMed1981

Further trials of nifurtimox in mucocutaneous leishmaniasis.

At a dosage level of 8 to 10 mg/kg body-weight daily for 120 days nifurtimox was associated with clinical healing of cutaneous leishmaniasis in five of eight patients. At a dosage level of 20 mg/kg body-weight daily for 10 days in six of 10 patients the skin ulcer healed. Results and the reasons why both schemes are impracticable are briefly discussed.

Adolescent↗
PubMed1981

Skin reactions to bug bites as a result of xenodiagnosis.

Cutaneous allergic reactions to bites of two bug species Triatoma infestans and Dipetalogaster maxima, were studied in an area where T. infestans is the local domestic vector. While more delayed skin reactions occurred with the indigenous vector, reactions also occurred with D. maxima. Repeated exposure to D. maxima produced more intense immediate skin reactions. First-stage D. maxima bugs produced a lower frequency and intensity of skin reaction. It is concluded that further work on this problem is necessary as it prejudices the use of xenodiagnosis in field surveys.

Animals↗
PubMed1980

A histological classification of mucocutaneous leishmaniasis in Brazil and its clinical evaluation.

Biopsies of skin and mucosal lesions were made on 60 well documented Brazilian patients with untreated cutaneous or mucocutaneous leishmaniasis, whose response to treatment was subsequently evaluated in 38 cases. The biopsies were examined with a view to classification after correlation with clinical and immunological findings. Although there was no simple or unified spectrum, five histological groups were defined and found to have some clinico-prognostic significance. In two groups the cases were all cutaneous with a relatively good prognosis. In another two groups they were evolving as mucocutaneous with a poor prognosis. The fifth group showed mixed characteristics with a tendency to relapse. There was no strong correlation with serum antibodies or Montenegro skin test, which were usually positive, or with parasite load, which was always low. The tissue response was distinguished from that in oriental sore by the degree of connective tissue involvement in all groups. It was the primary response in two groups, and subsidiary to a mono-nuclear response in the others. It suggested damage due to extra-cellular parasites or immune complexes. It did not correlate with the distinction between cutaneous and mucocutaneous disease. The single, most favourable, prognostic feature in either the cellular or connective tissue component was necrosis with a reactive response.

Antibodies↗
PubMed1980

Studies of the persistence of infectivity of Trypanosoma cruzi. III. Effect of human sweat.

Experiments designed to investigate the suggestion that human sweat has a trypanocidal effect did not support this hypothesis under the test conditions described. These studies are designed to investigate factors influencing the chance of infection of man when metacyclic trypanosomes in bug faeces are deposited on the human skin. As mentioned in the first paper in this series (Alvarenga & Marsden) we have epidemiological evidence that people can live for years in houses with infected bugs and not acquire the disease although skin contamination with infected faeces must occur frequently. Wood showed that metacyclic trypanosomes of T. cruzi lost their motility within 30 minutes after exposure to human sweat. He did not report infectivity experiments. Since such an effect would limit the chances of T. cruzi transmission under field conditions we decided to repeat Wood's experiments with observations on the infectivity of trypanosome suspensions.

Animals↗