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Biomedical subjects

P D Woolley

Publications and source records attributed to P D Woolley.

At least 37 records · Page 2Linked to original sources
PubMed1990

Incidence of herpes simplex virus type-1 and type-2 from patients with primary (first-attack) genital herpes in Sheffield.

In a study to determine the herpes simplex virus (HSV) type isolated from patients with primary (first-attack) genital herpes and to identify any clinical or epidemiological features that might influence the reported incidence of any particular viral type, there was almost an equal incidence of HSV-1 and HSV-2 isolated from women (48% versus 52%). In the case of women, the initial clinical diagnosis was correct in 97% with HSV-1 and 95% with HSV-2 infection. Amongst men, HSV-2 was isolated more frequently than HSV-1 (71% versus 29%). However, the initial clinical diagnosis in men was correct in only 53% with HSV-1 and 83% with HSV-2 infection. These results suggest that in primary genital herpes the incidence of HSV-1 and HSV-2 is probably equal, while in men the reported incidence of HSV-1 may be affected by underdiagnosis giving a falsely high incidence of HSV-2 infection.

Adult↗
PubMed1990

Comparative study of cefuroxime axetil and procaine penicillin in the treatment of uncomplicated gonorrhoea.

A total of 311 patients presenting with uncomplicated gonorrhoea were entered into a comparative randomized open-label study and given single-dose treatment with either oral cefuroxime axetil (CAE) or intramuscular procaine penicillin (PP). Neisseria gonorrhoeae was eliminated from 129 (98%) of 131 evaluable patients treated with CAE and 127 (98%) of 129 evaluable patients treated with PP. None of the 4 treatment failures (3 male and 1 female) were caused by beta-lactamase-producing isolates. Both treatments were well tolerated with minor adverse events reported in 3 (2%) of CAE treated patients. We conclude that CAE is an effective, well tolerated treatment for uncomplicated gonorrhoea which has the convenience and acceptability of single-dose oral therapy.

Administration, Oral↗
PubMed1988

Prostitution in Sheffield: differences between prostitutes.

This study to assess differences between street walking prostitutes and sauna girls who attended this clinic in 1986 and 1987 showed that fewer street walkers used barrier methods for disease prevention with clients or accepted tests for antibody to human immunodeficiency virus (HIV) when offered and more street walkers practised their profession in both Sheffield and London. They therefore represent a potential pathway for the heterosexual spread of HIV to the region. Trichomonas vaginalis was the only organism more commonly isolated from street walkers. Other sexually transmitted diseases diagnosed, and the sources of acquisition of gonococcal cervicitis, were similar in both groups of prostitutes. Prostitutes rarely used barrier methods with their regular consorts, who were found to be responsible for most cases of gonorrhoea in both groups. As 11 out of 58 prostitutes attending were found to have dysplasia on routine cervical cytological examination, we suggest that all prostitutes be advised to undergo cytology yearly.

Contraception Behavior↗
PubMed1987

Epidemiological treatment of sexual contacts prevents recurrence of non-gonococcal urethritis.

Of 98 male patients with non-gonococcal urethritis (NGU) who had regular female consorts who received concurrent epidemiological treatment, NGU recurred in four (16%) men whose treated partners were initially chlamydia positive and 20 (27%) men whose treated partners were initially chlamydia negative. Of 32 men whose regular female sexual partners refused to attend, 26 (77%) men suffered a recurrence of NGU. All study patients were selected because they were in monogamous relationships and returned to the clinic either because of a recurrence of NGU or for unrelated reasons at least 12 months after treatment. We recommend the routine epidemiological treatment of all sexual contacts of men with NGU.

Adolescent↗