Biomedical subjects
Publications and source records attributed to P Dagnelie.
Pancuronium 0.02--0.08 mg kg-1 induced a dose-related increase of heart rate in patients anaesthetized with nitrous oxide supplemented with either fentanyl 0.003 mg kg-1 or fentanyl 0.003 mg kg-1 plus droperidol 0.15 mg kg-1. The tachycardia was more marked following the administration of droperidol.
The action of droperidol on the tachycardia produced by atropine and on the serum concentration of cholinesterases was observed during balanced anaesthesia. Without atropine, the mean heart rates of patients who received fentanyl plus droperidol were similar. Atropine increased heart rate only in the presence of droperidol (P less than 0.001) (fentanyl v. fentanyl plus droperidol: P less than 0.05). Droperidol inhibited serum cholinesterases (P less than 0.05); this effect was independent of atropine.