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P Danger

Publications and source records attributed to P Danger.

4 recordsLinked to original sources
PubMed1995

Simultaneous determination of itraconazole, hydroxy-itraconazole and amphotericin B in human plasma by HPLC with photodiode array detection.

A method for the fast analysis of itraconazole, hydroxy-itraconazole and amphotericin B is described which has the advantage of speed and specificity. The method is based on methanolic extraction of the compounds from plasma, followed by reverse-phase high-performance liquid chromatography with two detection wavelengths (263 and 405 nm). The extraction step provides > or = 94% recovery and the response of the detection system is linear from 50 to 5000 ng/ml. No other drugs have been found to interfere with the assay.

Amphotericin B↗
PubMed1993

Monitoring of benzodiazepines (clobazam, diazepam and their main active metabolites) in human plasma by column-switching high-performance liquid chromatography.

A column-switching high-performance liquid chromatographic method for the simultaneous determination of clobazam, diazepam and their main metabolites in human plasma is described. A 200-microliters plasma sample was directly injected into a precolumn filled with TSK-gel PW. After a washing step with potassium phosphate buffer, the retained substances were backflushed into a reversed-phase column with a mobile phase of acetonitrile-phosphate buffer-diethylamine. Various drugs frequently co-administered with clobazam or diazepam do not interfere with the determination.

Anti-Anxiety Agents↗