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P De Remigis

Publications and source records attributed to P De Remigis.

12 recordsLinked to original sources
PubMed2006

Vitiligo associated with other autoimmune diseases: polyglandular autoimmune syndrome types 3B+C and 4.

Vitiligo is a common skin disease characterized by depigmented maculae resulting from a reduction of the number and function of melanocytes. Many studies suggest that vitiligo might be an autoimmune disease. Vitiligo has been frequently described in association with other autoimmune diseases. Among the diseases described in association with vitiligo are the so-called autoimmune polyglandular syndromes (APS). Vitiligo can be present in all types of APS but the most frequent association appears to be in APS-3. APS-3 was defined as the association between autoimmune thyroiditis and another autoimmune disease. Here we report one patient with thyroiditis, vitiligo and autoimmune gastritis (APS-3B+C), one patient with chronic autoimmune thyroiditis, vitiligo and alopecia (APS-3C), and one case of a young patient with type 1 diabetes mellitus and vitiligo (APS-4), according to the newest classification. We stress the importance of a thorough assessment for autoimmune diseases in selected patients with vitiligo.

Adult↗
PubMed1998

Effect of thyroid function on LDL oxidation.

In this study, the effect of different levels of thyroid hormone and metabolic activity on low density lipoprotein (LDL) oxidation was investigated. Thus, in 16 patients with hyperthyroidism, 16 with hypothyroidism, and 16 age- and sex-matched healthy normolipidemic control subjects, the native LDL content in lipid peroxides, vitamin E, beta-carotene, and lycopene, as well as the susceptibility of these particles to undergo lipid peroxidation, was assessed. Hyperthyroidism was associated with significantly higher lipid peroxidation, as characterized by a higher native LDL content in lipid peroxides, a lower lag phase, and a higher oxidation rate than in the other two groups. This elevated lipid peroxidation was associated with a lower LDL antioxidant concentration. Interestingly, hypothyroid patients showed an intermediate behavior. In fact, in hypothyroidism, LDL oxidation was significantly lower than in hyperthyroidism but higher than in the control group. Hypothyroidism was also characterized by the highest beta-carotene LDL content, whereas vitamin E was significantly lower than in control subjects. In hyperthyroidism but not in the other two groups, LDL oxidation was strongly influenced by free thyroxine blood content. In fact in this group, the native LDL lipid peroxide content and the lag phase were directly and indirectly, respectively, related to free thyroxine blood levels. On the contrary, in hypothyroidism LDL oxidation was strongly and significantly related to serum lipids. In conclusion, both hypothyroidism and hyperthyroidism are characterized by higher levels of LDL oxidation when compared with normolipidemic control subjects. In hyperthyroid patients, the increased lipid peroxidation was strictly related to free thyroxine levels, whereas in hypothyroidism it was strongly influenced by serum lipids.

Antioxidants↗
PubMed1990

Circadian time structure of pituitary and adrenal response to CRF, TRH and LHRH.

In six healthy males, aged 25.3 +/- 0.66, the pituitary and adrenal simultaneous response to CRF (1 microgram/kg), TRH (200 micrograms) and LH-RH (100 micrograms) was studied at the following times of different days: 0400, 0800, 1200, 1600, 2000 and 0000. Each test was preceded by a 8-hr fast after a meal containing 600 cal (CHO 50%, lipid 30%, protein 20%). The interval between two consecutive tests was 52 hrs and the starting time was randomized. The serum cortisol was measured before and after 60, 120, 180, 240 min. Serum TSH, Prolactin, FSH and LH were measured before and after 5, 10, 15, 30, 60, 90 and 120 min. The statistical analysis was reported by both mean chronograms (as absolute values and relative change or absolute difference from mesor) and mean cosinor on basal values and total (T.A.) or incremental (I.A.) areas after RH stimulus. Serum cortisol: a statistically significant circadian rhythm was found for basal values with a peak in the morning (phi at 1040; 95% C.L. 0808-1438). T.A. after RH stimulus as well appeared statistically higher again in the morning, whereas the I.A. presented an opposite phase with higher values at night (phi at 2133; 95% C.L. 2055-0312). Serum Prolactin: mean chronogram analysis showed significantly higher basal values at 0800 and lower values at 1600, whereas I.A. were significantly lower in the morning. Serum LH: basal values were statistically higher in the morning, while T.A. and I.A. showed an opposite behaviour with peaks in the night (T.A.: phi at 2015, 95% C.L. 1710-0035; I.A.: 0 2033; 95% C.L. 1736-0004).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Is zinc deficiency a cause of subclinical hypothyroidism in Down syndrome?

In Down syndrome there is a high incidence of overt or subclinical hypothyroidism as well as some immunological defects, early thymic involution associated to low serum zinc levels. Zinc supplementation to the diet has been reported to transiently improve thymic function; moreover thymic function has been shown to be in relation with the pituitary-thyroid axis. The aim of this study was to evaluate if, in Down patients, zinc therapy could improve also thyroid function, by determining serum levels of total and free thyroid hormones and basal TSH levels. In 52 patients studied, we found a high incidence of subclinical hypothyroidism (30%); in 17 patients treated with zinc sulphate we showed a reduction of FT3. More significantly, we detected 9 patients with low zinc levels in which zinc supplementation improved thyroid function, thus reducing the incidence of subclinical hypothyroidism.

Adolescent↗
PubMed1987

Glutathione metabolizing enzyme activities in human thyroid.

Glutathione peroxidases, glutathione transferase, glutathione reductase and gamma-glutamyl transpeptidase activities were analyzed in human thyroid tissues obtained from 17 patients undergoing resectional surgery because of a malignancy. It was deduced, from measurements of glutathione peroxidase activity with both H202 and cumene hydroperoxide, that thyroid contains only the selenium enzyme. The absence of selenium independent glutathione peroxidase activity in thyroid was confirmed with gel filtration experiments. An interindividual variation of about 28-fold was found measuring glutathione transferase activity with 1-chloro-2,4-dinitrobenzene. Subjecting a fraction of human thyroid cytosols partially purified by G-100 Sephadex column to isoelectricfocusing run, a single peak of glutathione transferase activity centered at pH 4.6 was obtained. An adequate level of glutathione reductase and gamma-glutamyl transpeptidase activities was also found in all specimens investigated.

Cytosol↗
PubMed1983

[Chronobiological study of free thyroid hormones in hypothyroid and hyperthyroid subjects].

Previous reports demonstrate a circadian rhythm of the free thyroid hormones in healthy subjects. In this study we evaluated circadian variation of FT3 and FT4 in hyperthyroid and hypothyroid states. We considered six hyperthyroid patients, six hypothyroid patients and six control subjects. Blood samples were taken two hours apart from a catherterized arm vein. Data were evaluated by Halberg's cosinor analysis. The results show that FT3 and FT4 exhibit a circadian rhythm in healthy subjects, not evident in hyperthyroid and hypothyroid patients.

Adult↗
PubMed1982

[The TRH test in latent thyroid pathology].

TRH-test is an usefull tool for diagnostic purpose in thyroid disease. We challenged with TRH 4 groups of patients (1 degrees non toxic diffuse goitre, 2 degrees nodular goitre (Plummer's disease), 3 degrees euthyroid ophthalmic Graves' disease, 4 degrees hemithyroidectomy) with different thyroid affections who showed no symptoms and presented normal values of total thyroid hormones, in comparison with a control group. These groups displayed normal and pathological (blunted or absent and exaggerated) responses of TSH to TRH. Therefore TRH-test ra presents a good mean to recognize subclinical forms both hyperthyroidism and hypothyroidism.

Humans↗
PubMed1982

[Clinical significance of triiodothyronine (T3) measurement].

The clinical significance of T3 assay is related to the discovery of T3 thyrotoxicosis, a form of hyperthyroidism caused by an overproduction of alone T3 with normal value of T4. We evaluated the prevalence and the clinical features of this form in a group of 850 subjects who were submitted to clinical examination and hormonal thyroid assay. We showed that T3 thyrotoxicosis is a mild condition of hyperthyroidism.

Adolescent↗
PubMedDate not supplied

Circadian rhythm of the PRL response to TRH in healthy subjects.

The PRL response to TRH constitutes an important clinical tool for diagnosing forms of hyperprolactinemic syndrome. Hence it is important to establish the characteristics of the circadian variation in the response of PRL to TRH to improve the diagnostic value of the test. Six male subjects, ranging in age from 23 to 24 years, participated in this study. All were considered healthy on the basis of clinical examination, biochemical and hormonal tests. Six TRH tests were performed on each subject, one test every other day during a total span of 12 days. Each test was performed at a different clock hour: 0000, 0400, 0800, 1200, 1600, 2000. For the test, subjects received 200 microgram TRH intravenously. Blood samples were drawn from a catheterized arm vein before the TRH injection (basal value) and 20, 30, 60 and 120 min after injection. At each timepoint 5 endpoints were determined for PRL on each subject. The population mean cosinor, according to Halberg, was used to investigate the circadian rhythm in each of the endpoints. All the 5 endpoints for PRL are consistent on showing p values near 0.5 and acrophase estimates before midnight (while basal value displays acrophase at 0400). Further investigations are necessary to clarify these circadian rhythms and the shift of the acrophases.

Adult↗