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P Deroff

Publications and source records attributed to P Deroff.

9 recordsLinked to original sources
PubMed1987

[Post-transfusion malaria. Partial statistical data. Preventive approach to detecting blood donors at risk].

The authors demonstrate the reality of post-transfusion malaria, define the plasmodial species involved, and insist on the responsibility of Plasmodium falciparum in the occurrence of major complications. A prophylactic approach is proposed, by researching anti-malarial antibodies in donors at risk. An I. F. A. (Indirect Immunofluorescence Assay) is performed (Falciparum Spot I. F., Bio-Mérieux, Lyon, France). The screening procedure relies heavily on medical history taking, but subsequent results are satisfying; moreover it seems they could be bettered by using specific monoclonal antibodies.

Antibodies↗
PubMed1986

[Prevention of post-transfusional malaria].

The Authors report the results over a four year-period of their protocol for the detection of blood donors at risk of harboring Plasmodium Falciparum and thence transmitting post-transfusional malaria. This protocol is based on donor questioning and antibody detection by an immunofluorescence assay. It has led to exclude from the direct transfusional network 0,41% of the draws, but then 1032 units have been reintegrated in the inventory without provoking any reported incident. A short study of the geographic origins of the infections confirms the World Health Organization (W.H.O.) data and allows to insist on high risk areas and even reveals previously unsuspected ones. As long as there is no available automated method, and, foremost, no direct parasitemia-detecting assay, this low-cost protocol seems satisfying.

Antibodies↗
PubMed1985

[The micro-computer card. Possible applications to transfusion from A to Z].

Following characteristics of micro-computer cards: inaccessibility to selected secret information; strong resistance to aggressive external agents; impossibility of altering stored data without destroying it; instant reading and reproduction by authorized services; make them a perfect material for building up individual records of civil and biological data. Their application to blood transfusion allows increased safety not only for blood donation registrations, but above all when transfusion takes place; they may also be used as credit cards for health expenditures. They consequently serve as real LIFE cards.

Blood Transfusion↗
PubMed1983

Screening blood donors for Plasmodium falciparum malariae. Application of ready-to-use homologous antigens.

Prevention of post-transfusion malaria remains a worrying problem. Until now it was very difficult to obtain homologous antigens, and immunologic methods used to detect malaria were expensive. We tested the ready-to-use Plasmodium falciparum prepared slides using the IFA (indirect fluorescent antibody) test on 866 selected potentially dangerous donors and known malaria cases. We found that it is a simple, quick, reliable and inexpensive method that can be easily used by blood banks and improve blood transfusion safety.

Antigens↗
PubMed1982

[Identification of blood donors capable of transmitting P. falciparum. Use of homologous antigenic preparations ready for use].

The smears of P. falciparum parasited blood ready to be employed, that we have tested in indirect immunofluorescence to detect blood donors who can be at the origin of post transfusional paludism, seem to offer a very important progress to us for the improvement of transfusion security. Their routine use can be recommended because their easy way of using allows their adoption by very many transfusion centers.

Antibodies↗
PubMed1982

Monoclonal gammopathies in the adult population of Finistère, France.

Three hundred and thirty-four monoclonal gammopathies were detected in the sera of 30 279 adults from Finistère. Monoclonal gammopathies (MG) are more common in Finistère than in Paris and their distribution is not homogeneous. IgG paraproteins are particularly common in the northeast of Finistère whereas IgM paraproteins are more common in the southwest. Family studies and the high degree of inbreeding would support the hypothesis that there is a genetic predisposition to develop MG but the occurrence of paraproteins among three non-consanguineous couples seems to favour the existence of an environmental factor.

Adult↗
PubMed1981

[Transfusional malaria in France (1960-1979) (author's transl)].

Transfusional Malaria is not a rare condition in France: in the past 20 years, 110 cases were cited in the literature and/or reported to us in answers to a recent questionnaire. Of these, 24 cases occurred between 1960 and 1969 and 78 between 1970 and 1979. This apparent increase in occurrence in the past decade is most probably due to the increase in the number of transfusions of whole blood or fresh fractions containing infected erythrocytes, although population exchanges with inter-tropical Africa may also play a preponderant role. Our study confirms that Plasmodium falciparum is the most prevalent pathogen responsible for this condition in France; it caused 84% of cases in the past five years. We think this point must be taken in account by the legislator.

Adult↗